Publications by authors named "Sinead Weldon"

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IFN-Mediated Bronchial Epithelium Cellular Senescence in Chronic Obstructive Pulmonary Disease.
Hong Guo-Parke, Oisin Cappa, Dermot A Linden, Ben S Barksby, Rachel A Burgoyne, Sinead Weldon

Am J Respir Cell Mol Biol· December 2025

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An immunoregulatory amphipathic peptide derived from Fasciola hepatica helminth defense molecule (FhHDM-1.C2) exhibits potent biotherapeutic activity in a murine model of multiple sclerosis.
Richard Lalor, Akane Tanaka, Jenna Shiels, Aakanksha Dixit, Sabine Hoadley, Sinead Weldon

FASEB J· February 2025

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PROTECTION OF MICE AGAINST CECAL LIGATION AND PUNCTURE-INDUCED POLYMICROBIAL SEPSIS BY A FASCIOLA HEPATICA HELMINTH DEFENSE MOLECULE.
Barbara Fazekas, Siobhán Hamon, Carolina De Marco Verissimo, Krystyna Cwiklinski, Jesús López Corrales, Sinéad Weldon

Shock· January 2025

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Mesenchymal stromal cells reduce inflammation and improve lung function in a mouse model of cystic fibrosis lung disease.
Declan F Doherty, Lydia E Roets, Caoifa M Dougan, Ryan R Brown, Ian J Hawthorne, Sinéad Weldon

Sci Rep· December 2024

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SLPI deficiency alters airway protease activity and induces cell recruitment in a model of muco-obstructive lung disease.
Ryan Brown, Caoifa Dougan, Peter Ferris, Rebecca Delaney, Claire J Houston, Sinéad Weldon

Front Immunol· September 2024

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PTEN Depletion Increases Radiosensitivity in Response to Ataxia Telangiectasia-Related-3 (ATR) Inhibition in Non-Small Cell Lung Cancer (NSCLC).
Victoria L Dunne, Mihaela Ghita-Pettigrew, Kelly M Redmond, Donna M Small, Sinéad Weldon

Int J Mol Sci· July 2024

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Airway Epithelium Senescence as a Driving Mechanism in COPD Pathogenesis.
Georgia Bateman, Hong Guo-Parke, Aoife M Rodgers, Dermot Linden, Melanie Bailey, Sinéad Weldon

Biomedicines· July 2023

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In vitro evaluation of the potential use of snake-derived peptides in the treatment of respiratory infections using inhalation therapy: A proof of concept study.
Shannice Creane, Mary Joyce, Ronan MacLoughlin, Sinéad Weldon, John P Dalton

Eur J Pharm Sci· April 2023

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Secretory Leucoprotease Inhibitor (SLPI) Promotes Survival during Acute Infection by Suppression of Inflammation Rather Than Microbial Killing.
Megan Osbourn, Aoife M Rodgers, Alice V Dubois, Donna M Small, Fiachra Humphries, Sinéad Weldon

Biomolecules· November 2022

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The Serpin-tine Search for Factors Associated with COVID-19 Severity in Patients with Chronic Obstructive Pulmonary Disease.
Aaron Scott, Sinéad Weldon, Clifford C Taggart

Am J Respir Crit Care Med· September 2022

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The relationship between plasma cystatin C, mortality and acute respiratory distress syndrome subphenotype in the HARP-2 trial.
Michael C McKelvey, Ian Bradbury, Cliona McDowell, Carolyn S Calfee, Sinead Weldon

Crit Care Resusc· September 2022

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Cathepsin S Contributes to Lung Inflammation in Acute Respiratory Distress Syndrome.
Michael C McKelvey, Anthony A Abladey, Donna M Small, Declan F Doherty, Richard Williams, Sinéad Weldon

Am J Respir Crit Care Med· April 2022

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Therapeutic Inhibition of Cathepsin S Reduces Inflammation and Mucus Plugging in Adult ENaC-Tg Mice.
Ryan Brown, Donna M Small, Declan F Doherty, Leslie Holsinger, Robert Booth, Sinéad Weldon

Mediators Inflamm· March 2022

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The Effect of CFTR Modulators on Airway Infection in Cystic Fibrosis.
Caitlyn Harvey, Sinead Weldon, Stuart Elborn, Damian G Downey, Clifford Taggart

Int J Mol Sci· March 2022

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Altered Differentiation and Inflammation Profiles Contribute to Enhanced Innate Responses in Severe COPD Epithelium to Rhinovirus Infection.
Hong Guo-Parke, Dermot Linden, Aurelie Mousnier, Ian C Scott, Helen Killick, Sinéad Weldon

Front Med (Lausanne)· February 2022

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Deciphering Respiratory-Virus-Associated Interferon Signaling in COPD Airway Epithelium.
Hong Guo-Parke, Dermot Linden, Sinéad Weldon, Joseph C Kidney, Clifford C Taggart

Medicina (Kaunas)· January 2022

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The Impact of Lung Proteases on Snake-Derived Antimicrobial Peptides.
Shannice E Creane, Simon R Carlile, Damian Downey, Sinéad Weldon, John P Dalton

Biomolecules· July 2021

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-Derived Molecules as Regulators of the Host Immune Response.
Sinéad Ryan, Jenna Shiels, Clifford C Taggart, John P Dalton, Sinéad Weldon

Front Immunol· May 2021

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Proteases, Mucus, and Mucosal Immunity in Chronic Lung Disease.
Michael C McKelvey, Ryan Brown, Sinéad Ryan, Marcus A Mall, Sinéad Weldon

Int J Mol Sci· May 2021

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Mechanisms of Virus-Induced Airway Immunity Dysfunction in the Pathogenesis of COPD Disease, Progression, and Exacerbation.
Hong Guo-Parke, Dermot Linden, Sinéad Weldon, Joseph C Kidney, Clifford C Taggart

Front Immunol· April 2021

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The Impact of Aging in Acute Respiratory Distress Syndrome: A Clinical and Mechanistic Overview.
Ryan Brown, Michael C McKelvey, Sinéad Ryan, Shannice Creane, Dermot Linden, Sinéad Weldon

Front Med (Lausanne)· October 2020

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Airway Inflammation and Host Responses in the Era of CFTR Modulators.
Karen Keown, Ryan Brown, Declan F Doherty, Claire Houston, Michael C McKelvey, Sinéad Weldon

Int J Mol Sci· September 2020

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Schistosoma mansoni immunomodulatory molecule Sm16/SPO-1/SmSLP is a member of the trematode-specific helminth defence molecules (HDMs).
Jenna Shiels, Krystyna Cwiklinski, Raquel Alvarado, Karine Thivierge, Sophie Cotton, Sinead Weldon

PLoS Negl Trop Dis· July 2020

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Cathepsin S: investigating an old player in lung disease pathogenesis, comorbidities, and potential therapeutics.
Ryan Brown, Sridesh Nath, Alnardo Lora, Ghassan Samaha, Ziyad Elgamal, Sinéad Weldon

Respir Res· May 2020

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At the forefront of cystic fibrosis Basic Science research: 16th ECFS Basic Science Conference.
Clifford C Taggart, Sinéad Weldon, Marcus A Mall

J Cyst Fibros· March 2020

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