Publications by authors named "Sita D Gupta"

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Characterization of novel and recurrent variants in childhood-onset amyotrophic lateral sclerosis: Insights into sphingolipid dysregulation.
Xiaona Fu, Kenneth Gable, Sita D Gupta, KaiLi Zhang, Bingbing Jia

J Neuromuscul Dis· August 2025

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Collaborative regulation of yeast SPT-Orm2 complex by phosphorylation and ceramide.
Tian Xie, Feitong Dong, Gongshe Han, Xinyue Wu, Peng Liu, Sita D Gupta

Cell Rep· February 2024

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Recurrent de novo variant causes childhood-onset amyotrophic lateral sclerosis (ALS) by excess sphingolipid synthesis.
Safoora B Syeda, Museer A Lone, Payam Mohassel, Sandra Donkervoort, Pinki Munot, Sita D Gupta

J Neurol Neurosurg Psychiatry· January 2024

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SPTSSA variants alter sphingolipid synthesis and cause a complex hereditary spastic paraplegia.
Siddharth Srivastava, Hagar Mor Shaked, Kenneth Gable, Sita D Gupta, Xueyang Pan

Brain· April 2023

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Mechanism of sphingolipid homeostasis revealed by structural analysis of SPT-ORM1 complex.
Peng Liu, Tian Xie, Xinyue Wu, Gongshe Han, Sita D Gupta

Sci Adv· March 2023

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The SPTLC1 p.S331 mutation bridges sensory neuropathy and motor neuron disease and has implications for treatment.
Chiara Fiorillo, Giovanna Capodivento, Alessandro Geroldi, Stefano Tozza, Isabella Moroni, Sita D Gupta

Neuropathol Appl Neurobiol· December 2022

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Childhood amyotrophic lateral sclerosis caused by excess sphingolipid synthesis.
Payam Mohassel, Sandra Donkervoort, Museer A Lone, Matthew Nalls, Kenneth Gable, Sita D Gupta

Nat Med· July 2021

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Structural insights into the regulation of human serine palmitoyltransferase complexes.
Yingdi Wang, Yiming Niu, Zhe Zhang, Kenneth Gable, Sita D Gupta

Nat Struct Mol Biol· March 2021

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The ORMs interact with transmembrane domain 1 of Lcb1 and regulate serine palmitoyltransferase oligomerization, activity and localization.
Gongshe Han, Sita D Gupta, Kenneth Gable, Dagmar Bacikova, Nivedita Sengupta

Biochim Biophys Acta Mol Cell Biol Lipids· March 2019

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Elevation of 20-carbon long chain bases due to a mutation in serine palmitoyltransferase small subunit b results in neurodegeneration.
Lihong Zhao, Stefka Spassieva, Kenneth Gable, Sita D Gupta, Lan-Ying Shi

Proc Natl Acad Sci U S A· October 2015

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Expression of the ORMDLS, modulators of serine palmitoyltransferase, is regulated by sphingolipids in mammalian cells.
Sita D Gupta, Kenneth Gable, Aikaterini Alexaki, Panagiotis Chandris, Richard L Proia

J Biol Chem· January 2015

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Autophagy regulates sphingolipid levels in the liver.
Aikaterini Alexaki, Sita D Gupta, Saurav Majumder, Mari Kono, Galina Tuymetova

J Lipid Res· December 2014

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The pyridoxal 5'-phosphate (PLP)-dependent enzyme serine palmitoyltransferase (SPT): effects of the small subunits and insights from bacterial mimics of human hLCB2a HSAN1 mutations.
Ashley E Beattie, Sita D Gupta, Lenka Frankova, Agne Kazlauskaite, Jeffrey M Harmon

Biomed Res Int· June 2014

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Topological and functional characterization of the ssSPTs, small activating subunits of serine palmitoyltransferase.
Jeffrey M Harmon, Dagmar Bacikova, Kenneth Gable, Sita D Gupta, Gongshe Han, Nivedita Sengupta

J Biol Chem· April 2013

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Sphingolipids in the root play an important role in regulating the leaf ionome in Arabidopsis thaliana.
Dai-Yin Chao, Kenneth Gable, Ming Chen, Ivan Baxter, Charles R Dietrich, Sita D Gupta

Plant Cell· March 2011

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A disease-causing mutation in the active site of serine palmitoyltransferase causes catalytic promiscuity.
Kenneth Gable, Sita D Gupta, Gongshe Han, Somashekarappa Niranjanakumari, Jeffrey M Harmon

J Biol Chem· July 2010

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Tsc10p and FVT1: topologically distinct short-chain reductases required for long-chain base synthesis in yeast and mammals.
Sita D Gupta, Kenneth Gable, Gongshe Han, Anna Borovitskaya, Luke Selby

J Lipid Res· August 2009

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Identification of small subunits of mammalian serine palmitoyltransferase that confer distinct acyl-CoA substrate specificities.
Gongshe Han, Sita D Gupta, Kenneth Gable, Somashekarappa Niranjanakumari, Prasun Moitra

Proc Natl Acad Sci U S A· May 2009

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The topology of the Lcb1p subunit of yeast serine palmitoyltransferase.
Gongshe Han, Ken Gable, Lianying Yan, Mukil Natarajan, Jayasree Krishnamurthy, Sita D Gupta

J Biol Chem· December 2004

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Low-temperature effect on the sterol-dependent processing of SREBPs and transcription of related genes in HepG2 cells.
Ishaiahu Shechter, Peihua Dai, Mark A Roseman, Sita D Gupta, Bert B Boyer

J Lipid Res· August 2003

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