Publications by authors named "Sivakumar Viswanathan"

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Interleukin-11 causes alveolar type 2 cell dysfunction and prevents alveolar regeneration.
Benjamin Ng, Kevin Y Huang, Chee Jian Pua, Sivakumar Viswanathan, Wei-Wen Lim

Nat Commun· October 2024

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Inhibition of IL-11 signalling extends mammalian healthspan and lifespan.
Anissa A Widjaja, Wei-Wen Lim, Sivakumar Viswanathan, Sonia Chothani, Ben Corden

Nature· August 2024

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Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease.
Anissa A Widjaja, Sivakumar Viswanathan, Shamini G Shekeran, Eleonora Adami, Wei-Wen Lim

Nat Commun· December 2022

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A high-resolution map of human RNA translation.
Sonia P Chothani, Eleonora Adami, Anissa A Widjaja, Sarah R Langley, Sivakumar Viswanathan

Mol Cell· August 2022

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IL11 stimulates ERK/P90RSK to inhibit LKB1/AMPK and activate mTOR initiating a mesenchymal program in stromal, epithelial, and cancer cells.
Anissa A Widjaja, Sivakumar Viswanathan, Joyce Goh Wei Ting, Jessie Tan, Shamini G Shekeran

iScience· August 2022

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IL11 Stimulates IL33 Expression and Proinflammatory Fibroblast Activation across Tissues.
Anissa A Widjaja, Sonia Chothani, Sivakumar Viswanathan, Joyce Wei Ting Goh, Wei-Wen Lim

Int J Mol Sci· August 2022

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Loss of Yap/Taz in cardiac fibroblasts attenuates adverse remodelling and improves cardiac function.
Masum M Mia, Dasan Mary Cibi, Siti Aishah Binte Abdul Ghani, Anamika Singh, Nicole Tee, Viswanathan Sivakumar

Cardiovasc Res· June 2022

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A Neutralizing IL-11 Antibody Improves Renal Function and Increases Lifespan in a Mouse Model of Alport Syndrome.
Anissa A Widjaja, Shamini G Shekeran, Eleonora Adami, Joyce G Wei Ting, Jessie Tan, Sivakumar Viswanathan

J Am Soc Nephrol· April 2022

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Inhibition of IL11 Signaling Reduces Aortic Pathology in Murine Marfan Syndrome.
Wei-Wen Lim, Jinrui Dong, Benjamin Ng, Anissa A Widjaja, Chen Xie, Sivakumar Viswanathan

Circ Res· March 2022

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IL11 Activates Pancreatic Stellate Cells and Causes Pancreatic Inflammation, Fibrosis and Atrophy in a Mouse Model of Pancreatitis.
Benjamin Ng, Sivakumar Viswanathan, Anissa A Widjaja, Wei-Wen Lim, Shamini G Shekeran

Int J Mol Sci· March 2022

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IL11 is elevated in systemic sclerosis and IL11-dependent ERK signalling underlies TGFβ-mediated activation of dermal fibroblasts.
Eleonora Adami, Sivakumar Viswanathan, Anissa A Widjaja, Benjamin Ng, Sonia Chothani

Rheumatology (Oxford)· December 2021

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Critical Conditions for Studying Interleukin-11 Signaling In Vitro and Avoiding Experimental Artefacts.
Sivakumar Viswanathan, Benjamin Ng, Anissa A Widjaja, Chee Jian Pua, Nevin Tham

Curr Protoc· September 2021

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Molecular Dissection of Pro-Fibrotic IL11 Signaling in Cardiac and Pulmonary Fibroblasts.
Anissa A Widjaja, Sivakumar Viswanathan, Dong Jinrui, Brijesh K Singh, Jessie Tan

Front Mol Biosci· September 2021

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The pro-regenerative effects of hyperIL6 in drug-induced liver injury are unexpectedly due to competitive inhibition of IL11 signaling.
Jinrui Dong, Sivakumar Viswanathan, Eleonora Adami, Sebastian Schafer, Fathima F Kuthubudeen

Elife· August 2021

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Similarities and differences between IL11 and IL11RA1 knockout mice for lung fibro-inflammation, fertility and craniosynostosis.
Benjamin Ng, Anissa A Widjaja, Sivakumar Viswanathan, Jinrui Dong, Sonia P Chothani

Sci Rep· July 2021

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Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury.
Anissa A Widjaja, Jinrui Dong, Eleonora Adami, Sivakumar Viswanathan, Benjamin Ng

Sci Transl Med· June 2021

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Antibody-mediated neutralization of IL11 signalling reduces ERK activation and cardiac fibrosis in a mouse model of severe pressure overload.
Wei-Wen Lim, Ben Corden, Lei Ye, Sivakumar Viswanathan, Anissa A Widjaja

Clin Exp Pharmacol Physiol· April 2021

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Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH.
Jinrui Dong, Sivakumar Viswanathan, Eleonora Adami, Brijesh K Singh, Sonia P Chothani

Nat Commun· January 2021

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Interleukin-11 is important for vascular smooth muscle phenotypic switching and aortic inflammation, fibrosis and remodeling in mouse models.
Wei-Wen Lim, Ben Corden, Benjamin Ng, Konstantinos Vanezis, Giuseppe D'Agostino, Sivakumar Viswanathan

Sci Rep· October 2020

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Fibroblast-specific IL11 signaling drives chronic inflammation in murine fibrotic lung disease.
Benjamin Ng, Jinrui Dong, Sivakumar Viswanathan, Anissa A Widjaja, Bhairav S Paleja

FASEB J· September 2020

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deltaTE: Detection of Translationally Regulated Genes by Integrative Analysis of Ribo-seq and RNA-seq Data.
Sonia Chothani, Eleonora Adami, John F Ouyang, Sivakumar Viswanathan, Norbert Hubner

Curr Protoc Mol Biol· December 2019

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Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Nonalcoholic Steatohepatitis.
Anissa A Widjaja, Brijesh K Singh, Eleonora Adami, Sivakumar Viswanathan, Jinrui Dong

Gastroenterology· September 2019

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Widespread Translational Control of Fibrosis in the Human Heart by RNA-Binding Proteins.
Sonia Chothani, Sebastian Schäfer, Eleonora Adami, Sivakumar Viswanathan, Anissa A Widjaja

Circulation· September 2019

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Interleukin-11 is a therapeutic target in idiopathic pulmonary fibrosis.
Benjamin Ng, Jinrui Dong, Giuseppe D'Agostino, Sivakumar Viswanathan, Anissa A Widjaja

Sci Transl Med· September 2019

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The Translational Landscape of the Human Heart.
Sebastiaan van Heesch, Franziska Witte, Valentin Schneider-Lunitz, Jana F Schulz, Eleonora Adami, Sivakumar Viswanathan

Cell· June 2019

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