Publications by authors named "Somesh K Jha"

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CRISPR editing of HPFH3 genotype induces γ-globin expression and reverses sickle cell disease and β-thalassemia phenotypes.
Sangam Giri Goswami, Pragya Gupta, V R Arvinden, Nupur Bhargava, Aditya Ramdas Iyer, Somesh K Jha

Stem Cell Res Ther· December 2025

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The mTORC2 subunit RICTOR drives breast cancer progression by promoting ganglioside biosynthesis through transcriptional and epigenetic mechanisms.
Mohammad Nafees Ansari, Somesh K Jha, Ali Khan, Kajal Rajput, Nishant Pandey

PLoS Biol· September 2025

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Engineered Nanomicelles Delivering the Combination of Steroids and Antioxidants Can Mitigate Local and Systemic Inflammation, Including Sepsis.
Kajal Rana, Poonam Yadav, Ruchira Chakraborty, Somesh K Jha, Usha Agrawal

ACS Appl Mater Interfaces· February 2025

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Engineered nanomicelles targeting proliferation and angiogenesis inhibit tumour progression by impairing the synthesis of ceramide-1-phosphate.
Poonam Yadav, Kajal Rana, Ruchira Chakraborty, Ali Khan, Devashish Mehta, Somesh K Jha

Nanoscale· May 2024

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Engineered nanomicelles inhibit the tumour progression via abrogating the prostaglandin-mediated immunosuppression.
Poonam Yadav, Kajal Rana, Viviani Nardini, Ali Khan, Trishna Pani, Somesh K Jha

J Control Release· April 2024

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A localized hydrogel-mediated chemotherapy causes immunogenic cell death via activation of ceramide-mediated unfolded protein response.
Animesh Kar, Dolly Jain, Sandeep Kumar, Kajal Rajput, Sanjay Pal, Somesh K Jha

Sci Adv· June 2023

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Ceramide Kinase (CERK) Emerges as a Common Therapeutic Target for Triple Positive and Triple Negative Breast Cancer Cells.
Kajal Rajput, Mohammad Nafees Ansari, Somesh K Jha, Trishna Pani, Nihal Medatwal

Cancers (Basel)· September 2022

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Hydrogel-mediated topical delivery of steroids can effectively alleviate psoriasis attenuating the autoimmune responses.
Kajal Rana, Trishna Pani, Somesh Kumar Jha, Devashish Mehta, Poonam Yadav

Nanoscale· March 2022

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Nonimmunogenic Hydrogel-Mediated Delivery of Antibiotics Outperforms Clinically Used Formulations in Mitigating Wound Infections.
Sandeep Kumar, Sanjay Pal, Jyoti Thakur, Parul Rani, Kajal Rana, Somesh Kumar Jha

ACS Appl Mater Interfaces· September 2021

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A hydrogel-based implantable multidrug antitubercular formulation outperforms oral delivery.
Sanjay Pal, Vijay Soni, Sandeep Kumar, Somesh Kumar Jha, Nihal Medatwal

Nanoscale· August 2021

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Hydrogel-mediated delivery of celastrol and doxorubicin induces a synergistic effect on tumor regression via upregulation of ceramides.
Nihal Medatwal, Mohammad Nafees Ansari, Sandeep Kumar, Sanjay Pal, Somesh Kumar Jha

Nanoscale· September 2020

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