Publications by authors named "Songwen Lin"

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Discovery and Optimization of Novel Tricyclic Ubiquitin-Specific Protease 1 Inhibitors for the Treatment of BRCA-Mutated Breast Cancer.
Tianning Xiong, Hong Yang, Songwen Lin, Li Sheng, Junpu Ge

J Med Chem· December 2025

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Discovery of Novel PI3K/BRD4 Dual Inhibitors for Esophageal Cancer: Rational Design, Optimization, and Senescence-Inducing Mechanisms.
Shouguo Peng, Yihui Yang, Wan Li, Songwen Lin, Shiji Chu

J Med Chem· November 2025

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Correction: Hou et al. S-72, a Novel Orally Available Tubulin Inhibitor, Overcomes Paclitaxel Resistance via Inactivation of the STING Pathway in Breast Cancer. 2023, , 749.
Zhenyan Hou, Songwen Lin, Tingting Du, Mingjin Wang, Weida Wang

Pharmaceuticals (Basel)· September 2025

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Targeting DDX3X suppresses progression of KRAS-driven lung cancer by disrupting antioxidative homeostasis and inducing ferroptosis.
Meijuan Dian, Liang Yun, Qingyu Meng, Songwen Lin, Ming Ji

Cell Death Dis· August 2025

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Optimization of Thienopyrimidine Derivatives as Potent and Selective PI3Kδ Inhibitors for Cancer Immunotherapy.
Songwen Lin, Nan Xiang, Wenqian Liu, Deyu Wu, Yiran Chen

J Med Chem· July 2025

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Discovery and Optimization of Potent PROTAC Degraders of Phosphoinositide 3-Kinase with Significant Anticancer Efficacy.
Shouguo Peng, Qinghua Zhang, Hua Tian, Jingbo Zhang, Jialing Deng, Songwen Lin

J Med Chem· June 2025

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Design, Synthesis, and Biological Evaluation of Novel Fms-Like Tyrosine Kinase 3/VEGFR2/Histone Deacetylase Inhibitors for the Treatment of Acute Myeloid Leukemia.
Hua Tian, Yichen Liu, Songwen Lin, Jialing Deng, Qinghua Zhang

J Med Chem· March 2025

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Design, synthesis and biological evaluation of a novel PSMA-PI3K small molecule drug conjugate.
Shouguo Peng, Haixia Li, Weilu Cui, Tianning Xiong, Jiaqi Hu, Songwen Lin

RSC Med Chem· August 2024

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Design, Synthesis, and Bioevaluation of Novel Reversibly Photoswitchable PI3K Inhibitors Based on Phenylazopyridine Derivatives toward Light-Controlled Cancer Treatment.
Yan Zhang, Jialing Deng, Hua Tian, Haixiang Qi, Tianning Xiong, Songwen Lin

J Med Chem· March 2024

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Rational design and optimization of novel 4-methyl quinazoline derivatives as PI3K/HDAC dual inhibitors with benzamide as zinc binding moiety for the treatment of acute myeloid leukemia.
Kehui Zhang, Rui Huang, Ming Ji, Songwen Lin, Fangfang Lai

Eur J Med Chem· January 2024

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Design, synthesis, and biological evaluation of novel bivalent PI3K inhibitors for the potential treatment of cancer.
Liang Xia, Lin Jiang, Tingting Du, Songwen Lin, Tianning Xiong

Bioorg Chem· November 2023

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Discovery of a Novel Photocaged PI3K Inhibitor Capable of Real-Time Reporting of Drug Release.
Hua Tian, Shen You, Tianning Xiong, Ming Ji, Kehui Zhang, Lin Jiang, Songwen Lin

ACS Med Chem Lett· August 2023

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S-72, a Novel Orally Available Tubulin Inhibitor, Overcomes Paclitaxel Resistance via Inactivation of the STING Pathway in Breast Cancer.
Zhenyan Hou, Songwen Lin, Tingting Du, Mingjin Wang, Weida Wang

Pharmaceuticals (Basel)· May 2023

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Optimization of Benzamide Derivatives as Potent and Orally Active Tubulin Inhibitors Targeting the Colchicine Binding Site.
Songwen Lin, Tingting Du, Jingbo Zhang, Deyu Wu, Hua Tian, Lin Jiang

J Med Chem· December 2022

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Discovery of a novel photoswitchable PI3K inhibitor toward optically-controlled anticancer activity.
Yan Zhang, Shouguo Peng, Songwen Lin, Ming Ji, Tingting Du

Bioorg Med Chem· October 2022

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Bioevaluation of a dual PI3K/HDAC inhibitor for the treatment of diffuse large B-cell lymphoma.
Kehui Zhang, Lei Huang, Fangfang Lai, Songwen Lin, Hua Tian

Bioorg Med Chem Lett· September 2022

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Design and Optimization of Thienopyrimidine Derivatives as Potent and Selective PI3Kδ Inhibitors for the Treatment of B-Cell Malignancies.
Jingbo Zhang, Huimin Jiang, Songwen Lin, Deyu Wu, Hua Tian, Lin Jiang

J Med Chem· June 2022

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A novel PI3K inhibitor XH30 suppresses orthotopic glioblastoma and brain metastasis in mice models.
Ming Ji, Dongjie Wang, Songwen Lin, Chunyang Wang, Ling Li

Acta Pharm Sin B· February 2022

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The PI3K Inhibitor XH30 Enhances Response to Temozolomide in Drug-Resistant Glioblastoma the Noncanonical Hedgehog Signaling Pathway.
Ming Ji, Zhihui Zhang, Songwen Lin, Chunyang Wang, Jing Jin

Front Pharmacol· November 2021

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Design, Synthesis, and Biological Evaluation of a Novel Photocaged PI3K Inhibitor toward Precise Cancer Treatment.
Kehui Zhang, Ming Ji, Songwen Lin, Shouguo Peng, Zhihui Zhang

J Med Chem· June 2021

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Discovery of new thieno[2,3-d]pyrimidine and thiazolo[5,4-d]pyrimidine derivatives as orally active phosphoinositide 3-kinase inhibitors.
Yan Sun, Rong Fu, Songwen Lin, Jingbo Zhang, Ming Ji

Bioorg Med Chem· January 2021

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A novel orally active microtubule destabilizing agent S-40 targets the colchicine-binding site and shows potent antitumor activity.
Tingting Du, Songwen Lin, Ming Ji, Nina Xue, Yichen Liu

Cancer Lett· December 2020

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Identification of Novel Thiazolo[5,4-]Pyridine Derivatives as Potent Phosphoinositide 3-Kinase Inhibitors.
Liang Xia, Yan Zhang, Jingbo Zhang, Songwen Lin, Kehui Zhang

Molecules· October 2020

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Discovery of 4-Methylquinazoline Based PI3K Inhibitors for the Potential Treatment of Idiopathic Pulmonary Fibrosis.
Songwen Lin, Jing Jin, Ying Liu, Hua Tian, Yan Zhang

J Med Chem· October 2019

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Switching the site-selectivity of C-H activation in aryl sulfonamides containing strongly coordinating N-heterocycles.
Yi Dong, XuePeng Zhang, Jiajing Chen, Wenxing Zou, Songwen Lin

Chem Sci· October 2019

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