Publications by authors named "Sornakala Ganeshkumar"

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Regulatory Role for Tumor Suppressor REST on Estrogen Receptor (ESR1) Expression and Leiomyoma Pathophysiology.
Skylar G Bird, Sumedha Gunewardena, Ashley Cloud, Sornakala Ganeshkumar, Vargheese M Chennathukuzhi

J Biol Chem· December 2025

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Regulatory Role for Tumor Suppressor REST on Estrogen Receptor () Expression and Leiomyoma Pathophysiology.
Skylar G Bird, Sumedha Gunewardena, Ashley Cloud, Sornakala Ganeshkumar, Vargheese M Chennathukuzhi

bioRxiv· August 2025

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Loss of PRICKLE1 leads to subfertility, aberrant extracellular matrix and abnormal myometrial architecture in mice.
Emily R Roberts, Sornakala Ganeshkumar, Sumedha Gunewardena, Vargheese Chennathukuzhi

Reproduction· March 2025

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Loss of PRICKLE1 leads to abnormal endometrial epithelial architecture, decreased embryo implantation, and reduced fertility in mice.
Emily R Roberts, Aishwarya V Bhurke, Sornakala Ganeshkumar, Sumedha Gunewardena, Ripla Arora

PNAS Nexus· February 2025

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Loss of PRICKLE1 leads to abnormal endometrial epithelial architecture, decreased embryo implantation, and reduced fertility in mice.
Emily R Roberts, Aishwarya V Bhurke, Sornakala Ganeshkumar, Sumedha Gunewardena, Ripla Arora

bioRxiv· August 2024

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Development of allosteric and selective CDK2 inhibitors for contraception with negative cooperativity to cyclin binding.
Erik B Faber, Luxin Sun, Jian Tang, Emily Roberts, Sornakala Ganeshkumar

Nat Commun· June 2023

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Loss of the repressor REST affects progesterone receptor function and promotes uterine leiomyoma pathogenesis.
Ashley S Cloud, Faezeh Koohestani, Michelle M McWilliams, Sornakala Ganeshkumar, Sumedha Gunewardena

Proc Natl Acad Sci U S A· November 2022

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Loss of REST in breast cancer promotes tumor progression through estrogen sensitization, MMP24 and CEMIP overexpression.
Ashley S Cloud, Aditya M Vargheese, Sumedha Gunewardena, Raeann M Shimak, Sornakala Ganeshkumar

BMC Cancer· February 2022

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