Publications by authors named "Srigiridhar Kotamraju"

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Palmitic acid fuels triple-negative breast cancer through metadherin-dependent fatty acid β-oxidation: Relevance to high fat diet-induced breast cancer progression.
Sunita Kumari, Shashikanta Sahoo, Sriravali Pulipaka, Annatta Thomas, Madhusudana Kuncha, Srigiridhar Kotamraju

Cell Signal· December 2025

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Doxorubicin Resistance Reprograms Triple-Negative Breast Cancer Cell Metabolism via the Fatty Acid β-Oxidation (FAO)-CD36 Regulatory Circuit: Relevance of Enhanced FAO on Tumor Cell Invasiveness.
Sunita Kumari, Shashikanta Sahoo, Annatta Thomas, Srigiridhar Kotamraju

Mol Carcinog· December 2025

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MTDH∆7-mediated mTOR activation drives doxorubicin resistance in triple-negative breast cancer: Relevance of mTORC1 inhibition on chemosensitization.
Shashikanta Sahoo, Sunita Kumari, Praveen Kumar Neeli, Sriravali Pulipaka, Madhusudana Kuncha, Srigiridhar Kotamraju

Cell Signal· August 2025

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SIRT1 promotes doxorubicin-induced breast cancer drug resistance and tumor angiogenesis via regulating GSH-mediated redox homeostasis.
Shashikanta Sahoo, Sunita Kumari, Sriravali Pulipaka, Yogesh Chandra, Srigiridhar Kotamraju

Mol Carcinog· December 2024

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Mitochondria targeted esculetin administration improves insulin resistance and hyperglycemia-induced atherosclerosis in db/db mice.
Gajalakshmi Singuru, Sriravali Pulipaka, Altab Shaikh, Shashikanta Sahoo, Aruna Jangam, Srigiridhar Kotamraju

J Mol Med (Berl)· July 2024

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Mitochondria-targeted esculetin and metformin delay endothelial senescence by promoting fatty acid β-oxidation: Relevance in age-associated atherosclerosis.
Sriravali Pulipaka, Hridya Chempon, Gajalakshmi Singuru, Shashikanta Sahoo, Altab Shaikh, Srigiridhar Kotamraju

Mech Ageing Dev· June 2024

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Therapeutic efficacies of mitochondria-targeted esculetin and metformin in the improvement of age-associated atherosclerosis via regulating AMPK activation.
Sriravali Pulipaka, Gajalakshmi Singuru, Shashikanta Sahoo, Altab Shaikh, Rajamannar Thennati, Srigiridhar Kotamraju

Geroscience· April 2024

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Correction to: Therapeutic efficacies of mitochondria‑targeted esculetin and metformin in the improvement of age‑associated atherosclerosis via regulating AMPK activation.
Sriravali Pulipaka, Gajalakshmi Singuru, Shashikanta Sahoo, Altab Shaikh, Rajamannar Thennati, Srigiridhar Kotamraju

Geroscience· April 2024

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Therapeutic efficacy of mitochondria-targeted esculetin in the improvement of NAFLD-NASH via modulating AMPK-SIRT1 axis.
Gajalakshmi Singuru, Sriravali Pulipaka, Altab Shaikh, Sai Balaji Andugulapati, Rajamannar Thennati, Srigiridhar Kotamraju

Int Immunopharmacol· November 2023

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DOT1L regulates MTDH-mediated angiogenesis in triple-negative breast cancer: intermediacy of NF-κB-HIF1α axis.
Praveen Kumar Neeli, Shashikanta Sahoo, Santosh Karnewar, Gajalakshmi Singuru, Sriravali Pulipaka, Srigiridhar Kotamraju

FEBS J· January 2023

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Mitochondria-targeted esculetin mitigates atherosclerosis in the setting of aging via the modulation of SIRT1-mediated vascular cell senescence and mitochondrial function in Apoe mice.
Santosh Karnewar, Sriravali Pulipaka, Sujana Katta, Devayani Panuganti, Praveen Kumar Neeli, Srigiridhar Kotamraju

Atherosclerosis· September 2022

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A functional and self-assembling octyl-phosphonium-tagged esculetin as an effective siRNA delivery agent.
Altab Shaikh, Praveen Kumar Neeli, Gajalakshmi Singuru, Sravya Panangipalli, Rajkumar Banerjee, Srigiridhar Kotamraju

Chem Commun (Camb)· November 2021

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sp -Rich Glycyrrhetinic Acid Analogues Using Late-Stage Functionalization as Potential Breast Tumor Regressing Agents.
Shivakrishna Kallepu, Praveen Kumar Neeli, Sreevidya Mallappa, Narendra Kumar Nagendla, Mohana Krishna Reddy Mudiam, Srigiridhar Kotamraju

ChemMedChem· October 2020

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A novel metadherinΔ7 splice variant enhances triple negative breast cancer aggressiveness by modulating mitochondrial function via NFĸB-SIRT3 axis.
Praveen Kumar Neeli, Paradesi Naidu Gollavilli, Sreevidya Mallappa, Sai Gayathri Hari, Srigiridhar Kotamraju

Oncogene· March 2020

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N-end rule pathway inhibitor sensitizes cancer cells to antineoplastic agents by regulating XIAP and RAD21 protein expression.
Subrata K Pore, Anirban Ganguly, Samaresh Sau, Sudhakar Godeshala, Anantha K Kanugula, Srigiridhar Kotamraju

J Cell Biochem· January 2020

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Doxorubicin induces prostate cancer drug resistance by upregulation of ABCG4 through GSH depletion and CREB activation: Relevance of statins in chemosensitization.
Sreevidya Mallappa, Praveen K Neeli, Santosh Karnewar, Srigiridhar Kotamraju

Mol Carcinog· July 2019

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Recent trends in electrochemical biosensors of superoxide dismutases.
Murugesan Balamurugan, Paulraj Santharaman, Thangamuthu Madasamy, Seenivasan Rajesh, Niroj Kumar Sethy, Srigiridhar Kotamraju

Biosens Bioelectron· September 2018

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High Affinity Neutral Bodipy Fluorophores for Mitochondrial Tracking.
Thumuganti Gayathri, Santosh Karnewar, Srigiridhar Kotamraju, Surya Prakash Singh

ACS Med Chem Lett· July 2018

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Metformin regulates mitochondrial biogenesis and senescence through AMPK mediated H3K79 methylation: Relevance in age-associated vascular dysfunction.
Santosh Karnewar, Praveen Kumar Neeli, Devayani Panuganti, Sasikumar Kotagiri, Sreevidya Mallappa, Srigiridhar Kotamraju

Biochim Biophys Acta Mol Basis Dis· April 2018

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Metformin treatment prevents SREBP2-mediated cholesterol uptake and improves lipid homeostasis during oxidative stress-induced atherosclerosis.
Raja Gopoju, Sravya Panangipalli, Srigiridhar Kotamraju

Free Radic Biol Med· April 2018

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Mitochondria-targeted esculetin inhibits PAI-1 levels by modulating STAT3 activation and miR-19b via SIRT3: Role in acute coronary artery syndrome.
Sujana Katta, Santosh Karnewar, Devayani Panuganti, Mahesh Kumar Jerald, B K S Sastry, Srigiridhar Kotamraju

J Cell Physiol· January 2018

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Novel Bioactive Wild Medicinal Mushroom--Xylaria sp. R006 (Ascomycetes) against Multidrug Resistant Human Bacterial Pathogens and Human Cancer Cell Lines.
Veluchamy Ramesh, Karnewar Santosh, Thangarajan Durai Anand, Vellasamy Shanmugaiah, Srigiridhar Kotamraju

Int J Med Mushrooms· December 2016

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Resveratrol attenuates monocyte-to-macrophage differentiation and associated inflammation via modulation of intracellular GSH homeostasis: Relevance in atherosclerosis.
Sathish Babu Vasamsetti, Santosh Karnewar, Raja Gopoju, Paradesi Naidu Gollavilli, Sai Ram Narra, Srigiridhar Kotamraju

Free Radic Biol Med· July 2016

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Free radical scavenging, α-glucosidase inhibitory and anti-inflammatory constituents from Indian sedges, R.Br and L.
Lavanya Kakarla, Suresh Babu Katragadda, Ashok K Tiwari, K Srigiridhar Kotamraju, K Madhusudana

Pharmacogn Mag· July 2016

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Mitochondria-targeted esculetin alleviates mitochondrial dysfunction by AMPK-mediated nitric oxide and SIRT3 regulation in endothelial cells: potential implications in atherosclerosis.
Santosh Karnewar, Sathish Babu Vasamsetti, Raja Gopoju, Anantha Koteswararao Kanugula, Sai Krishna Ganji, Srigiridhar Kotamraju

Sci Rep· April 2016

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