Publications by authors named "Ssu-Ju Fu"

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A fly model of SCA36 reveals combinatorial neurotoxicity of hexanucleotide and dipeptide repeats.
Cheng-Tsung Hsiao, Ssu-Ju Fu, Ting-Ni Guo, Chia-Chi Lin, Yu-Jung Tsao

PLoS Genet· December 2025

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Regulation of testosterone synthesis in Leydig cells by ClC-2 chloride channel.
Ssu-Ju Fu, Min-Shan Syu, Chih-Yu Tang, Ching-Yuan Huang, Chung-Jiuan Jeng

Reproduction· August 2025

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Intrafamilial Phenotypic Variation in Taiwanese Patients with Hereditary Spastic Paraplegia and Charcot-Marie-Tooth Disease Due to KIF5A Mutations: A Cross-Sectional Observational Study.
Po-Yu Lin, Cheng-Tsung Hsiao, Han-Wei Huang, Yi-Jen Wu, Ssu-Ju Fu

Acta Neurol Taiwan· June 2025

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Restoration of Shal/K4 proteostasis and motor function in a Drosophila model of spinocerebellar ataxia type 19/22.
Cheng-Tsung Hsiao, Ssu-Ju Fu, Kai-Min Cheng, Hsiang Lo, Chih-Yung Tang

Cell Mol Life Sci· April 2025

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Pin1 promotes human Ca2.1 channel polyubiquitination by RNF138: pathophysiological implication for episodic ataxia type 2.
Ssu-Ju Fu, Kai-Min Cheng, Cheng-Tsung Hsiao, Ya-Ching Fang, Chung-Jiuan Jeng

Cell Commun Signal· November 2024

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Neuronal Exosomes Secreted under Oxygen-Glucose Deprivation/Reperfusion Presenting Differentially Expressed miRNAs and Affecting Neuronal Survival and Neurite Outgrowth.
Chien-Sung Chiang, Ssu-Ju Fu, Chia-Lang Hsu, Chung-Jiuan Jeng, Chih-Yung Tang

Neuromolecular Med· September 2021

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Identification of MKRN1 as a second E3 ligase for Eag1 potassium channels reveals regulation via differential degradation.
Ya-Ching Fang, Ssu-Ju Fu, Po-Hao Hsu, Pei-Tzu Chang, Jing-Jia Huang

J Biol Chem· September 2021

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Rare Gain-of-Function Variant Associated with Cerebellar Ataxia, Parkinsonism, Cognitive Dysfunction, and Brain Iron Accumulation.
Cheng-Tsung Hsiao, Thomas F Tropea, Ssu-Ju Fu, Tanya M Bardakjian, Pedro Gonzalez-Alegre

Int J Mol Sci· July 2021

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Novel Variant Underlying Nonprogressive Congenital Ataxia or SCA19/22 Disrupt K4.3 Protein Expression and K+ Currents with Variable Effects on Channel Properties.
Ginevra Zanni, Cheng-Tsung Hsiao, Ssu-Ju Fu, Chih-Yung Tang, Alessandro Capuano

Int J Mol Sci· May 2021

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Regulation of ClC-2 Chloride Channel Proteostasis by Molecular Chaperones: Correction of Leukodystrophy-Associated Defect.
Ssu-Ju Fu, Meng-Chun Hu, Cheng-Tsung Hsiao, An-Ting Cheng, Tsung-Yu Chen

Int J Mol Sci· May 2021

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CUL4-DDB1-CRBN E3 Ubiquitin Ligase Regulates Proteostasis of ClC-2 Chloride Channels: Implication for Aldosteronism and Leukodystrophy.
Ssu-Ju Fu, Meng-Chun Hu, Yi-Jheng Peng, Hsin-Yu Fang, Cheng-Tsung Hsiao

Cells· May 2020

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Defective Gating and Proteostasis of Human ClC-1 Chloride Channel: Molecular Pathophysiology of Myotonia Congenita.
Chung-Jiuan Jeng, Ssu-Ju Fu, Chia-Ying You, Yi-Jheng Peng, Cheng-Tsung Hsiao

Front Neurol· February 2020

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Novel SCA19/22-associated KCND3 mutations disrupt human K 4.3 protein biosynthesis and channel gating.
Cheng-Tsung Hsiao, Ssu-Ju Fu, Yo-Tsen Liu, Yi-Hsiang Lu, Ciao-Yu Zhong

Hum Mutat· November 2019

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FKBP8 Enhances Protein Stability of the CLC-1 Chloride Channel at the Plasma Membrane.
Yi-Jheng Peng, Yi-Ching Lee, Ssu-Ju Fu, Yun-Chia Chien, Yi-Fan Liao

Int J Mol Sci· November 2018

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Ubiquitin Ligase RNF138 Promotes Episodic Ataxia Type 2-Associated Aberrant Degradation of Human Ca2.1 (P/Q-Type) Calcium Channels.
Ssu-Ju Fu, Chung-Jiuan Jeng, Chia-Hao Ma, Yi-Jheng Peng, Chi-Ming Lee

J Neurosci· March 2017

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The episodic ataxia type 1 mutation I262T alters voltage-dependent gating and disrupts protein biosynthesis of human Kv1.1 potassium channels.
Szu-Han Chen, Ssu-Ju Fu, Jing-Jia Huang, Chih-Yung Tang

Sci Rep· January 2016

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The Eag domain regulates the voltage-dependent inactivation of rat Eag1 K+ channels.
Ting-Feng Lin, Guey-Mei Jow, Hsin-Yu Fang, Ssu-Ju Fu, Hao-Han Wu

PLoS One· June 2015

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14-3-3θ is a binding partner of rat Eag1 potassium channels.
Po-Hao Hsu, Shi-Chuen Miaw, Chau-Ching Chuang, Pei-Yu Chang, Ssu-Ju Fu

PLoS One· April 2013

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