Publications by authors named "Stacy Springs"

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Selective Enrichment of Full Capsids of Adeno-Associated Virus.
Vivekananda Bal, Jacqueline M Wolfrum, Paul W Barone, Stacy L Springs, Anthony J Sinskey

ACS Nano· October 2025

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Rapid Universal Detection of High-Risk and Low-Abundance Microbial Contaminations in CAR-T Cell Therapy.
Xiaolin Wu, Joshua Jebaraj Raymond, Yaoping Liu, Alexander Jeremias Odermatt, Wei-Xiang Sin, Stacy L Springs

Small Methods· August 2025

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Perfusion-Based Production of rAAV via an Intensified Transient Transfection Process.
Tam N T Nguyen, Damdae Park, Christopher T Canova, Jose Sangerman, Prasanna Srinivasan, Stacy L Springs

Biotechnol Bioeng· June 2025

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An Integrated Experimental and Modeling Approach for Crystallization of Complex Biotherapeutics.
Vivekananda Bal, Moo Sun Hong, Jacqueline M Wolfrum, Paul W Barone, Stacy L Springs

Cryst Growth Des· June 2025

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A sensitive sample preparation pipeline for adventitious virus detection using Oxford Nanopore sequencing.
Emmanuel K Tsinda, Charles A Swofford, James P B Strutt, José Sangerman, Raeuf Roushangar, Stacy L Springs

Mol Ther Methods Clin Dev· June 2025

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Chemical sensing as a utility using parallel, distributed swept source Raman spectroscopy.
Nili Persits, Dahlia L Dry, Jaehwan Kim, Dragana Bozinovski, Naresh Mohan, Stacy L Springs

Opt Express· June 2025

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Extracellular viral microRNAs as biomarkers of virus infection in human cells.
Cheryl Chan, Joanne Xin Yi Loh, Wei-Xiang Sin, Denise Bei Lin Teo, Nicholas Kwan Zen Tan, Stacy L Springs

Mol Ther Nucleic Acids· March 2025

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Machine learning aided UV absorbance spectroscopy for microbial contamination in cell therapy products.
Shruthi Pandi Chelvam, Alice Jie Ying Ng, Jiayi Huang, Elizabeth Lee, Maciej Baranski, Stacy L Springs

Sci Rep· March 2025

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Upskilling the cell therapy manufacturing workforce: design, implementation, and evaluation of a massive open online course.
Mingyu Yang, Flora J Keumurian, Caleb Neufeld, Elizabeth Skrip, John Duguid, Stacy L Springs

Adv Physiol Educ· December 2024

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Multidose transient transfection of human embryonic kidney 293 cells modulates recombinant adeno-associated virus2/5 Rep protein expression and influences the enrichment fraction of filled capsids.
Prasanna Srinivasan, Christopher T Canova, Sha Sha, Tam N T Nguyen, John Joseph, Stacy L Springs

Biotechnol Bioeng· December 2024

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The state of technological advancement to address challenges in the manufacture of rAAV gene therapies.
Francesco Destro, Weida Wu, Prasanna Srinivasan, John Joseph, Vivekananda Bal, Stacy L Springs

Biotechnol Adv· November 2024

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Electrostatic microfiltration (EM) enriches and recovers viable microorganisms at low-abundance in large-volume samples and enhances downstream detection.
Yaoping Liu, Joshua J Raymond, Xiaolin Wu, Patrina Wei Lin Chua, Sharon Yan Han Ling, Stacy L Springs

Lab Chip· September 2024

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Development and Application of a Data-Driven Signal Detection Method for Surveillance of Adverse Event Variability Across Manufacturing Lots of Biologics.
Joshua T Wilde, Stacy Springs, Jacqueline M Wolfrum, Retsef Levi

Drug Saf· November 2023

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Continuous Online Titer Monitoring in CHO Cell Culture Supernatant Using a Herringbone Nanofluidic Filter Array.
Zhumei Rohskopf, Taehong Kwon, Sung Hee Ko, Dragana Bozinovski, Hyungkook Jeon, Stacy L Springs

Anal Chem· October 2023

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Mechanistic modeling explains the production dynamics of recombinant adeno-associated virus with the baculovirus expression vector system.
Francesco Destro, John Joseph, Prasanna Srinivasan, Joshua M Kanter, Caleb Neufeld, Stacy L Springs

Mol Ther Methods Clin Dev· September 2023

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Machine learning-based detection of adventitious microbes in T-cell therapy cultures using long-read sequencing.
James P B Strutt, Meenubharathi Natarajan, Elizabeth Lee, Denise Bei Lin Teo, Wei-Xiang Sin, Stacy L Springs

Microbiol Spectr· August 2023

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MIT CAACB Risk Assessment Case Study: Assessing Virus Cross-Contamination Risk between Two Simultaneous Processes in an Open Biomanufacturing Facility.
Andrea L Koenigsberg, Veronica Fowler, Reuben Domike, Audrey Brussel, Paul W Barone, Stacy L Springs

PDA J Pharm Sci Technol· April 2023

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Historical evaluation of the in vivo adventitious virus test and its potential for replacement with next generation sequencing (NGS).
Paul W Barone, Flora J Keumurian, Caleb Neufeld, Andrea Koenigsberg, Robert Kiss, Stacy L Springs

Biologicals· February 2023

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Structure and specificity of an anti-chloramphenicol single domain antibody for detection of amphenicol residues.
Charles A Swofford, Sarah A Nordeen, Lu Chen, Mahaam M Desai, Joanna Chen, Stacy L Springs

Protein Sci· November 2022

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The ratio of nicotinic acid to nicotinamide as a microbial biomarker for assessing cell therapy product sterility.
Jiayi Huang, Liang Cui, Meenubharathi Natarajan, Paul W Barone, Jacqueline M Wolfrum, Stacy L Springs

Mol Ther Methods Clin Dev· June 2022

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A warm-start digital CRISPR/Cas-based method for the quantitative detection of nucleic acids.
Xiaolin Wu, Cheryl Chan, Stacy L Springs, Yie Hou Lee, Timothy K Lu

Anal Chim Acta· March 2022

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Weighing the DNA Content of Adeno-Associated Virus Vectors with Zeptogram Precision Using Nanomechanical Resonators.
Georgios Katsikis, Iris E Hwang, Wade Wang, Vikas S Bhat, Nicole L McIntosh, Stacy L Springs

Nano Lett· February 2022

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Large-scale cultured meat production: Trends, challenges and promising biomanufacturing technologies.
Lu Chen, Donovan Guttieres, Andrea Koenigsberg, Paul W Barone, Anthony J Sinskey, Stacy L Springs

Biomaterials· January 2022

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Model-based control for column-based continuous viral inactivation of biopharmaceuticals.
Moo Sun Hong, Amos E Lu, Rui Wen Ou, Jacqueline M Wolfrum, Stacy L Springs

Biotechnol Bioeng· August 2021

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Mechanistic model for production of recombinant adeno-associated virus via triple transfection of HEK293 cells.
Tam N T Nguyen, Sha Sha, Moo Sun Hong, Andrew J Maloney, Paul W Barone, Stacy L Springs

Mol Ther Methods Clin Dev· June 2021

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