Publications by authors named "Stephan A Pless"

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The sodium leak channel NALCN is regulated by neuronal SNARE complex proteins.
Samuel Usher, Estelle Toulmé, Roberta Florea, Stanislau Yatskevich, Christine C Jao, Stephan A Pless

Sci Adv· March 2025

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Conformational plasticity of human acid-sensing ion channel 1a.
James Cahill, Kimberly A Hartfield, Stephanie Andrea Heusser, Mette Homann Poulsen, Craig Yoshioka, Stephan Alexander Pless

bioRxiv· December 2024

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Dynamic conformational changes of acid-sensing ion channels in different desensitizing conditions.
Caroline Marcher Holm, Asli B Topaktas, Johs Dannesboe, Stephan A Pless, Stephanie A Heusser

Biophys J· July 2024

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Protein semisynthesis underscores the role of a conserved lysine in activation and desensitization of acid-sensing ion channels.
Debayan Sarkar, Iacopo Galleano, Stephanie Andrea Heusser, Sofie Yuewei Ou, Gül Refika Uzun, Stephan Alexander Pless

Cell Chem Biol· May 2024

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Unplugging lateral fenestrations of NALCN reveals a hidden drug binding site within the pore region.
Katharina Schott, Samuel George Usher, Oscar Serra, Vincenzo Carnevale, Stephan Alexander Pless

Proc Natl Acad Sci U S A· May 2024

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Human P2X7 receptor variants Gly150Arg and Arg276His polymorphisms have differential effects on risk association and cellular functions in pancreatic cancer.
Lara Magni, Haoran Yu, Nynne M Christensen, Mette H Poulsen, Alexander Frueh, Stephan A Pless

Cancer Cell Int· April 2024

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Unplugging lateral fenestrations of NALCN reveals a hidden drug binding site within the pore module.
Katharina Schott, Samuel George Usher, Oscar Serra, Vincenzo Carnevale, Stephan Alexander Pless

bioRxiv· January 2024

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P2X2 receptor subunit interfaces are missense variant hotspots, where mutations tend to increase apparent ATP affinity.
Federica Gasparri, Debayan Sarkar, Sarune Bielickaite, Mette Homann Poulsen, Alexander Sebastian Hauser, Stephan Alexander Pless

Br J Pharmacol· July 2022

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Structural architecture of the human NALCN channelosome.
Marc Kschonsak, Han Chow Chua, Claudia Weidling, Nourdine Chakouri, Cameron L Noland, Stephan Alexander Pless

Nature· March 2022

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Structure-guided unlocking of Na reveals a non-selective tetrodotoxin-sensitive cation channel.
Cameron L Noland, Han Chow Chua, Marc Kschonsak, Stephanie Andrea Heusser, Nina Braun, Stephan Alexander Pless

Nat Commun· March 2022

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Conformational decoupling in acid-sensing ion channels uncovers mechanism and stoichiometry of PcTx1-mediated inhibition.
Stephanie A Heusser, Christian B Borg, Janne M Colding, Stephan A Pless

Elife· February 2022

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The suitability of high throughput automated patch clamp for physiological applications.
Alison Obergrussberger, Ilka Rinke-Weiß, Tom A Goetze, Markus Rapedius, Nina Brinkwirth, Stephan A Pless

J Physiol· January 2022

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Acid-sensing ion channels as potential therapeutic targets.
Stephanie A Heusser, Stephan A Pless

Trends Pharmacol Sci· December 2021

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The gating pore blocker 1-(2,4-xylyl)guanidinium selectively inhibits pacemaking of midbrain dopaminergic neurons.
Kevin Jehasse, Laurent Massotte, Sebastian Hartmann, Romain Vitello, Sofian Ringlet, Stephan A Pless

Neuropharmacology· October 2021

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The M1 and pre-M1 segments contribute differently to ion selectivity in ASICs and ENaCs.
Zeshan P Sheikh, Matthias Wulf, Søren Friis, Mike Althaus, Timothy Lynagh, Stephan A Pless

J Gen Physiol· October 2021

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High-throughput characterization of photocrosslinker-bearing ion channel variants to map residues critical for function and pharmacology.
Nina Braun, Søren Friis, Christian Ihling, Andrea Sinz, Jacob Andersen, Stephan A Pless

PLoS Biol· September 2021

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Functional cross-talk between phosphorylation and disease-causing mutations in the cardiac sodium channel Na1.5.
Iacopo Galleano, Hendrik Harms, Koushik Choudhury, Keith Khoo, Lucie Delemotte, Stephan Alexander Pless

Proc Natl Acad Sci U S A· August 2021

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Ion channel engineering using protein trans-splicing.
Debayan Sarkar, Hendrik Harms, Iacopo Galleano, Zeshan Pervez Sheikh, Stephan Alexander Pless

Methods Enzymol· June 2021

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Structure of the human sodium leak channel NALCN.
Marc Kschonsak, Han Chow Chua, Cameron L Noland, Claudia Weidling, Thomas Clairfeuille, Stephan Alexander Pless

Nature· November 2020

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Peptide Inhibitors of the α-Cobratoxin-Nicotinic Acetylcholine Receptor Interaction.
Timothy Lynagh, Stephan Kiontke, Maria Meyhoff-Madsen, Bengt H Gless, Jónas Johannesen, Stephan Alexander Pless

J Med Chem· November 2020

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Mechanism and site of action of big dynorphin on ASIC1a.
Christian B Borg, Nina Braun, Stephanie A Heusser, Yasmin Bay, Daniel Weis, Stephan A Pless

Proc Natl Acad Sci U S A· March 2020

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Evolutionarily Conserved Interactions within the Pore Domain of Acid-Sensing Ion Channels.
Marina A Kasimova, Timothy Lynagh, Zeshan Pervez Sheikh, Daniele Granata, Christian Bernsen Borg, Stephan Alexander Pless

Biophys J· February 2020

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Determinants of ion selectivity in ASIC1a- and ASIC2a-containing acid-sensing ion channels.
Timothy Lynagh, Emelie Flood, Céline Boiteux, Zeshan Pervez Sheikh, Toby W Allen, Stephan A Pless

J Gen Physiol· February 2020

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Molecular determinants for agonist recognition and discrimination in P2X2 receptors.
Federica Gasparri, Jesper Wengel, Thomas Grutter, Stephan A Pless

J Gen Physiol· July 2019

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A tale of ligands big and small: an update on how pentameric ligand-gated ion channels interact with agonists and proteins.
Stephan A Pless, Lucia G Sivilotti

Curr Opin Physiol· June 2019

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