Publications by authors named "Stephan G Zech"

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Creating a more strategic small molecule biophysical hit characterization workflow.
Christopher Fotsch, Debaleena Basu, Ryan Case, Qing Chen, Pratibha C Koneru, Stephan G Zech

SLAS Discov· June 2024

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Discovery of mobocertinib, a potent, oral inhibitor of EGFR exon 20 insertion mutations in non-small cell lung cancer.
Wei-Sheng Huang, Feng Li, Yongjin Gong, Yun Zhang, Willmen Youngsaye, Stephan G Zech

Bioorg Med Chem Lett· January 2023

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Addressing Atropisomerism in the Development of Sotorasib, a Covalent Inhibitor of KRAS G12C: Structural, Analytical, and Synthetic Considerations.
Brian A Lanman, Andrew T Parsons, Stephan G Zech

Acc Chem Res· October 2022

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Mobocertinib (TAK-788): A Targeted Inhibitor of Exon 20 Insertion Mutants in Non-Small Cell Lung Cancer.
Francois Gonzalvez, Sylvie Vincent, Theresa E Baker, Alexandra E Gould, Shuai Li, Stephan G Zech

Cancer Discov· July 2021

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Discovery of a Covalent Inhibitor of KRAS (AMG 510) for the Treatment of Solid Tumors.
Brian A Lanman, Jennifer R Allen, John G Allen, Albert K Amegadzie, Kate S Ashton, Stephan G Zech

J Med Chem· January 2020

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Novel Small Molecule Inhibitors of Choline Kinase Identified by Fragment-Based Drug Discovery.
Stephan G Zech, Anna Kohlmann, Tianjun Zhou, Feng Li, Rachel M Squillace

J Med Chem· January 2016

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Fragment growing and linking lead to novel nanomolar lactate dehydrogenase inhibitors.
Anna Kohlmann, Stephan G Zech, Feng Li, Tianjun Zhou, Rachel M Squillace

J Med Chem· February 2013

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Identification of novel rapamycin derivatives as low-level impurities in active pharmaceutical ingredients.
Stephan G Zech, Michael Carr, Qurish K Mohemmad, Narayana I Narasimhan, Christopher Murray

J Antibiot (Tokyo)· September 2011

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EP-2104R: a fibrin-specific gadolinium-Based MRI contrast agent for detection of thrombus.
Kirsten Overoye-Chan, Steffi Koerner, Richard J Looby, Andrew F Kolodziej, Stephan G Zech

J Am Chem Soc· May 2008

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Protein binding to lanthanide(III) complexes can reduce the water exchange rate at the lanthanide.
Stephan G Zech, Harriet B Eldredge, Mark P Lowe, Peter Caravan

Inorg Chem· April 2007

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Determination of the hydration number of gadolinium(III) complexes by high-field pulsed 17O ENDOR spectroscopy.
Arnold M Raitsimring, Andrei V Astashkin, Debbie Baute, Daniela Goldfarb, Oleg G Poluektov, Stephan G Zech

Chemphyschem· July 2006

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Probing the water coordination of protein-targeted MRI contrast agents by pulsed ENDOR spectroscopy.
Stephan G Zech, Wei-Chuan Sun, Vincent Jacques, Peter Caravan, Andrei V Astashkin

Chemphyschem· December 2005

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When are two waters worse than one? Doubling the hydration number of a Gd-DTPA derivative decreases relaxivity.
Peter Caravan, John C Amedio, Stephen U Dunham, Matthew T Greenfield, Normand J Cloutier, Stephan G Zech

Chemistry· October 2005

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Protein structure determination by high-resolution solid-state NMR spectroscopy: application to microcrystalline ubiquitin.
Stephan G Zech, A Joshua Wand, Ann E McDermott

J Am Chem Soc· June 2005

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Characterization of protein-ligand interactions by high-resolution solid-state NMR spectroscopy.
Stephan G Zech, Edward Olejniczak, Philip Hajduk, Jamey Mack, Ann E McDermott

J Am Chem Soc· November 2004

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Electron transfer in cyanobacterial photosystem I: I. Physiological and spectroscopic characterization of site-directed mutants in a putative electron transfer pathway from A0 through A1 to FX.
Wu Xu, Parag Chitnis, Alfia Valieva, Art van der Est, Yulia N Pushkar, Stephan G Zech

J Biol Chem· July 2003

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Electron transfer in cyanobacterial photosystem I: II. Determination of forward electron transfer rates of site-directed mutants in a putative electron transfer pathway from A0 through A1 to FX.
Wu Xu, Parag R Chitnis, Alfia Valieva, Art van der Est, Klaus Brettel, Stephan G Zech

J Biol Chem· July 2003

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Ionic states of substrates and transition state analogues at the catalytic sites of N-ribosyltransferases.
Anthony A Sauve, Sean M Cahill, Stephan G Zech, Luiz A Basso, Andrzej Lewandowicz

Biochemistry· May 2003

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Assembly of photosystem I. II. Rubredoxin is required for the in vivo assembly of F(X) in Synechococcus sp. PCC 7002 as shown by optical and EPR spectroscopy.
Gaozhong Shen, Mikhail L Antonkine, Art van der Est, Ilya R Vassiliev, Klaus Brettel, Stephan G Zech

J Biol Chem· June 2002

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