Publications by authors named "Stephane Daffis"

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TLR8 agonist selgantolimod regulates Kupffer cell differentiation status and impairs HBV entry into hepatocytes via an IL-6-dependent mechanism.
Armando Andres Roca Suarez, Marie-Laure Plissonnier, Xavier Grand, Maud Michelet, Guillaume Giraud, Stephane Daffis

Gut· November 2024

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Immunotherapeutic Strategies as Potential Treatment Options for Cutaneous Leishmaniasis.
Andrea Lafleur, Stephane Daffis, Charles Mowbray, Byron Arana

Vaccines (Basel)· October 2024

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Alternating Arenavirus Vector Immunization Generates Robust Polyfunctional Genotype Cross-Reactive Hepatitis B Virus-Specific CD8 T-Cell Responses and High Anti-Hepatitis B Surface Antigen Titers.
Sarah Schmidt, Meron Mengistu, Stephane Daffis, Sarah Ahmadi-Erber, Daniela Deutschmann

J Infect Dis· April 2024

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Phenotypic CD8 T cell profiling in chronic hepatitis B to predict HBV-specific CD8 T cell susceptibility to functional restoration in vitro.
Marzia Rossi, Andrea Vecchi, Camilla Tiezzi, Valeria Barili, Paola Fisicaro, Stephane Daffis

Gut· November 2023

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Safety, pharmacokinetics and pharmacodynamics of selgantolimod, an oral Toll-like receptor 8 agonist: a Phase Ia study in healthy subjects.
Maribel Reyes, Justin D Lutz, Audrey H Lau, Anuj Gaggar, Ethan P Grant, Stephane Daffis

Antivir Ther· October 2021

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Therapeutic Potential of TLR8 Agonist GS-9688 (Selgantolimod) in Chronic Hepatitis B: Remodeling of Antiviral and Regulatory Mediators.
Oliver E Amin, Emily J Colbeck, Stephane Daffis, Shahzada Khan, Dhivya Ramakrishnan

Hepatology· July 2021

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Toll-Like Receptor 8 Agonist GS-9688 Induces Sustained Efficacy in the Woodchuck Model of Chronic Hepatitis B.
Stephane Daffis, Scott Balsitis, Jason Chamberlain, Jim Zheng, Rex Santos

Hepatology· January 2021

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Discovery of GS-9688 (Selgantolimod) as a Potent and Selective Oral Toll-Like Receptor 8 Agonist for the Treatment of Chronic Hepatitis B.
Richard L Mackman, Michael Mish, Gregory Chin, Jason K Perry, Todd Appleby, Stephane Daffis

J Med Chem· September 2020

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Double Lock of a Human Neutralizing and Protective Monoclonal Antibody Targeting the Yellow Fever Virus Envelope.
Xishan Lu, Haixia Xiao, Shihua Li, Xuefei Pang, Jian Song, Stephane Daffis

Cell Rep· January 2019

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Anti-HBV response to toll-like receptor 7 agonist GS-9620 is associated with intrahepatic aggregates of T cells and B cells.
Li Li, Vivian Barry, Stephane Daffis, Congrong Niu, Erik Huntzicker

J Hepatol· May 2018

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Toll-like receptor 7 agonist GS-9620 induces prolonged inhibition of HBV via a type I interferon-dependent mechanism.
Congrong Niu, Li Li, Stephane Daffis, Julie Lucifora, Marc Bonnin

J Hepatol· May 2018

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Direct antiviral properties of TLR ligands against HBV replication in immune-competent hepatocytes.
Julie Lucifora, Marc Bonnin, Ludovic Aillot, Floriane Fusil, Sarah Maadadi, Stéphane Daffis

Sci Rep· March 2018

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The Smc5/6 Complex Restricts HBV when Localized to ND10 without Inducing an Innate Immune Response and Is Counteracted by the HBV X Protein Shortly after Infection.
Congrong Niu, Christine M Livingston, Li Li, Rudolf K Beran, Stephane Daffis

PLoS One· August 2017

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Sustained efficacy and seroconversion with the Toll-like receptor 7 agonist GS-9620 in the Woodchuck model of chronic hepatitis B.
Stephan Menne, Daniel B Tumas, Katherine H Liu, Linta Thampi, Dalal AlDeghaither, Stephane Daffis

J Hepatol· June 2015

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West Nile virus noncoding subgenomic RNA contributes to viral evasion of the type I interferon-mediated antiviral response.
Andrea Schuessler, Anneke Funk, Helen M Lazear, Daphne A Cooper, Shessy Torres, Stephane Daffis

J Virol· May 2012

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A temporal role of type I interferon signaling in CD8+ T cell maturation during acute West Nile virus infection.
Amelia K Pinto, Stephane Daffis, James D Brien, Maria D Gainey, Wayne M Yokoyama

PLoS Pathog· December 2011

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Interferon regulatory factor-1 (IRF-1) shapes both innate and CD8(+) T cell immune responses against West Nile virus infection.
James D Brien, Stephane Daffis, Helen M Lazear, Hyelim Cho, Mehul S Suthar

PLoS Pathog· September 2011

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The naturally attenuated Kunjin strain of West Nile virus shows enhanced sensitivity to the host type I interferon response.
Stephane Daffis, Helen M Lazear, Wen Jun Liu, Michelle Audsley, Michael Engle

J Virol· June 2011

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The innate immune adaptor molecule MyD88 restricts West Nile virus replication and spread in neurons of the central nervous system.
Kristy J Szretter, Stephane Daffis, Jigisha Patel, Mehul S Suthar, Robyn S Klein

J Virol· December 2010

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2'-O methylation of the viral mRNA cap evades host restriction by IFIT family members.
Stephane Daffis, Kristy J Szretter, Jill Schriewer, Jianqing Li, Soonjeon Youn

Nature· November 2010

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Measure and countermeasure: type I IFN (IFN-alpha/beta) antiviral response against West Nile virus.
Stephane Daffis, Mehul S Suthar, Michael Gale, Michael S Diamond

J Innate Immun· July 2010

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IPS-1 is essential for the control of West Nile virus infection and immunity.
Mehul S Suthar, Daphne Y Ma, Sunil Thomas, Jennifer M Lund, Nu Zhang, Stephane Daffis

PLoS Pathog· February 2010

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Induction of IFN-beta and the innate antiviral response in myeloid cells occurs through an IPS-1-dependent signal that does not require IRF-3 and IRF-7.
Stephane Daffis, Mehul S Suthar, Kristy J Szretter, Michael Gale, Michael S Diamond

PLoS Pathog· October 2009

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Toll-like receptor 3 has a protective role against West Nile virus infection.
Stephane Daffis, Melanie A Samuel, Mehul S Suthar, Michael Gale, Michael S Diamond

J Virol· November 2008

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Interferon regulatory factor IRF-7 induces the antiviral alpha interferon response and protects against lethal West Nile virus infection.
Stephane Daffis, Melanie A Samuel, Mehul S Suthar, Brian C Keller, Michael Gale

J Virol· September 2008

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