Publications by authors named "Stephanie Safgren"

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Phase I Trial of Selinexor in Pediatric Recurrent/Refractory Solid and CNS Tumors (ADVL1414): A Children's Oncology Group Phase I Consortium Trial.
Adam L Green, Charles G Minard, Xiaowei Liu, Stephanie L Safgren, Kerice Pinkney

Clin Cancer Res· May 2025

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The impact of coadministration of venlafaxine, citalopram or gabapentin on the metabolic activation of tamoxifen.
Stephanie L Safgren, Vera J Suman, Roberto A Leon Ferre, Matthew L Kosel, Vered Stearns

Breast Cancer Res Treat· May 2025

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De novo and inherited monoallelic variants in TUBA4A cause ataxia and spasticity.
Mehdi Benkirane, Marion Bonhomme, Heba Morsy, Stephanie L Safgren, Cecilia Marelli

Brain· November 2024

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Semiautomated approach focused on new genomic information results in time and effort-efficient reannotation of negative exome data.
Alejandro Ferrer, Patrick Duffy, Rory J Olson, Michael A Meiners, Laura Schultz-Rogers, Stephanie Safgren

Hum Genet· May 2024

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Dominant-negative heterozygous mutations in AIRE confer diverse autoimmune phenotypes.
Bergithe E Oftedal, Kristian Assing, Safa Baris, Stephanie L Safgren, Isik S Johansen

iScience· June 2023

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Bioavailability and Pharmacokinetics of Endoxifen in Female Rats and Dogs: Evidence to Support the Use of Endoxifen to Overcome the Limitations of CYP2D6-Mediated Tamoxifen Metabolism.
Emily J Koubek, Sarah A Buhrow, Stephanie L Safgren, Lee Jia, Matthew P Goetz

Drug Metab Dispos· February 2023

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MacroH2A histone variants modulate enhancer activity to repress oncogenic programs and cellular reprogramming.
Wazim Mohammed Ismail, Amelia Mazzone, Flavia G Ghiraldini, Jagneet Kaur, Manvir Bains, Stephanie L Safgren

Commun Biol· February 2023

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Oncogenic deubiquitination controls tyrosine kinase signaling and therapy response in acute lymphoblastic leukemia.
Qi Jin, Blanca Gutierrez Diaz, Tim Pieters, Yalu Zhou, Sonali Narang, Stephanie L Safgren

Sci Adv· December 2022

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De novo PBX1 variant in a patient with glaucoma, kidney anomalies, and developmental delay: An expansion of the CAKUTHED phenotype.
Stephanie L Safgren, Rory J Olson, Filippo Pinto E Vairo, Erick D Bothun, Christian Hanna

Am J Med Genet A· March 2022

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RAS mutations drive proliferative chronic myelomonocytic leukemia via a KMT2A-PLK1 axis.
Ryan M Carr, Denis Vorobyev, Terra Lasho, David L Marks, Ezequiel J Tolosa, Stephanie L Safgren

Nat Commun· May 2021

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GLI1/GLI2 functional interplay is required to control Hedgehog/GLI targets gene expression.
Ezequiel J Tolosa, Maite G Fernandez-Barrena, Eriko Iguchi, Angela L McCleary-Wheeler, Ryan M Carr, Stephanie L Safgren

Biochem J· September 2020

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Cancer-specific CTCF binding facilitates oncogenic transcriptional dysregulation.
Celestia Fang, Zhenjia Wang, Cuijuan Han, Stephanie L Safgren, Kathryn A Helmin

Genome Biol· September 2020

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The transcription factor GLI1 cooperates with the chromatin remodeler SMARCA2 to regulate chromatin accessibility at distal DNA regulatory elements.
Stephanie L Safgren, Rachel L O Olson, Anne M Vrabel, Luciana L Almada, David L Marks

J Biol Chem· June 2020

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Antitumor activity of Z-endoxifen in aromatase inhibitor-sensitive and aromatase inhibitor-resistant estrogen receptor-positive breast cancer.
Swaathi Jayaraman, Xiaonan Hou, Mary J Kuffel, Vera J Suman, Tanya L Hoskin, Stephanie L Safgren

Breast Cancer Res· May 2020

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The extracellular sulfatase SULF2 promotes liver tumorigenesis by stimulating assembly of a promoter-looping GLI1-STAT3 transcriptional complex.
Ryan M Carr, Paola A Romecin Duran, Ezequiel J Tolosa, Chenchao Ma, Abdul M Oseini, Stephanie L Safgren

J Biol Chem· February 2020

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A Phase II Study of Alisertib in Children with Recurrent/Refractory Solid Tumors or Leukemia: Children's Oncology Group Phase I and Pilot Consortium (ADVL0921).
Yael P Mossé, Elizabeth Fox, David T Teachey, Joel M Reid, Stephanie L Safgren

Clin Cancer Res· June 2019

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Pharmacokinetics of dacarbazine (DTIC) in pregnancy.
Ira Kantrowitz-Gordon, Karen Hays, Olumide Kayode, Aditya R Kumar, Henry G Kaplan, Stephanie L Safgren

Cancer Chemother Pharmacol· March 2018

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First-in-Human Phase I Study of the Tamoxifen Metabolite Z-Endoxifen in Women With Endocrine-Refractory Metastatic Breast Cancer.
Matthew P Goetz, Vera J Suman, Joel M Reid, Don W Northfelt, Michael A Mahr, Stephanie L Safgren

J Clin Oncol· October 2017

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Molecular Modeling and Functional Analysis of Exome Sequencing-Derived Variants of Unknown Significance Identify a Novel, Constitutively Active FGFR2 Mutant in Cholangiocarcinoma.
Jan B Egan, David L Marks, Tara L Hogenson, Anne M Vrabel, Ashley N Sigafoos, Stephanie L Safgren

JCO Precis Oncol· August 2017

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Pancreatic Cancer, A Mis-interpreter of the Epigenetic Language.
Eriko Iguchi, Stephanie L Safgren, David L Marks, Rachel L Olson, Martin E Fernandez-Zapico

Yale J Biol Med· December 2016

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Evaluation of CYP2D6 enzyme activity using a 13C-dextromethorphan breath test in women receiving adjuvant tamoxifen.
Stephanie L Safgren, Vera J Suman, Matthew L Kosel, Judith A Gilbert, Sarah A Buhrow

Pharmacogenet Genomics· April 2015

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Comparative uterotrophic effects of endoxifen and tamoxifen in ovariectomized Sprague-Dawley rats.
Karen M Schweikart, Sandy R Eldridge, Stephanie L Safgren, Toufan Parman, Joel M Reid

Toxicol Pathol· December 2014

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Pharmacokinetics of endoxifen and tamoxifen in female mice: implications for comparative in vivo activity studies.
Joel M Reid, Matthew P Goetz, Sarah A Buhrow, Chad Walden, Stephanie L Safgren

Cancer Chemother Pharmacol· December 2014

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Loss of heterozygosity at the CYP2D6 locus in breast cancer: implications for germline pharmacogenetic studies.
Matthew P Goetz, James X Sun, Vera J Suman, Grace O Silva, Charles M Perou, Stephanie L Safgren

J Natl Cancer Inst· December 2014

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UGT1A1 genotype-guided phase I study of irinotecan, oxaliplatin, and capecitabine.
Matthew P Goetz, Heidi A McKean, Joel M Reid, Sumithra J Mandrekar, Angelina D Tan, Stephanie L Safgren

Invest New Drugs· December 2013

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