Publications by authors named "Stephen Apple"

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Phase 3b Extension Study MT-1186-A04 to Evaluate the Continued Efficacy and Safety of Edaravone Oral Suspension for Up to an Additional 48 Weeks in Patients With Amyotrophic Lateral Sclerosis.
Angela Genge, Jeffrey Rothstein, Shari De Silva, Lorne Zinman, Marvin Chum, Stephen Apple

Muscle Nerve· December 2025

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Analysis of Long-Term Function and Survival of Edaravone Oral Suspension-Treated Patients With Amyotrophic Lateral Sclerosis Using PRO-ACT Data as Historical Placebo Controls.
Fumihiro Takahashi, Angela Genge, Manabu Hirai, Daniel Selness, Vesna Todorovic, Stephen Apple

Muscle Nerve· October 2025

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Efficacy and Safety of Once Daily Dosing vs. Approved On/Off Dosing of Edaravone Oral Suspension Up to 48 Weeks in Patients With Amyotrophic Lateral Sclerosis (Study MT-1186-A02).
Jeffrey Rothstein, Angela Genge, Shari De Silva, Lorne Zinman, Marvin Chum, Stephen Apple

Muscle Nerve· September 2025

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Safety Extension Study of Edaravone Oral Suspension in Patients With Amyotrophic Lateral Sclerosis for up to an Additional 96 Weeks of Treatment.
Angela Genge, Gary L Pattee, Gen Sobue, Masashi Aoki, Hiide Yoshino, Stephen Apple

Muscle Nerve· September 2025

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Efficacy of Radicava® IV (intravenous edaravone) in subjects with differing trajectories of disease progression in amyotrophic lateral sclerosis: Use of a novel statistical approach for post hoc analysis of a pivotal phase 3 clinical trial.
Erik P Pioro, Benjamin Rix Brooks, Ying Liu, Jeffrey Zhang, Stephen Apple

J Neurol Sci· December 2024

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The effects of intervention with intravenous edaravone in Study 19 on hospitalization, tracheostomy, ventilation, and death in patients with amyotrophic lateral sclerosis.
Benjamin Rix Brooks, Erik P Pioro, Takeshi Sakata, Fumihiro Takahashi, Melissa Hagan, Stephen Apple

Muscle Nerve· October 2023

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Design and performance characterization of a new LISA-like (laser interferometer space antenna-like) gravitational reference sensor and torsion pendulum testbed.
Stephen Apple, Anthony Dávila Álvarez, Samantha Parry Kenyon, Andrew Chilton, Derek Klein

Rev Sci Instrum· May 2023

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Oral edaravone demonstrated a favorable safety profile in patients with amyotrophic lateral sclerosis after 48 weeks of treatment.
Angela Genge, Gary L Pattee, Gen Sobue, Masashi Aoki, Hiide Yoshino, Stephen Apple

Muscle Nerve· February 2023

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Pharmacokinetics, Bioavailability, and Swallowing Safety With Riluzole Oral Film.
James Wymer, Stephen Apple, Antoinette Harrison, Bryan Alan Hill

Clin Pharmacol Drug Dev· January 2023

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Analysis of the US Safety Data for Edaravone (Radicava) From the Third Year After Launch.
Angela Genge, Benjamin Rix Brooks, Björn Oskarsson, Alexander Kalin, Ming Ji, Stephen Apple

Drugs R D· September 2022

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Edaravone efficacy in amyotrophic lateral sclerosis with reduced forced vital capacity: Post-hoc analysis of Study 19 (MCI186-19) [clinical trial NCT01492686].
Benjamin Rix Brooks, Terry Heiman-Patterson, Martina Wiedau-Pazos, Shawn Liu, Jeffrey Zhang, Stephen Apple

PLoS One· June 2022

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Evidence for generalizability of edaravone efficacy using a novel machine learning risk-based subgroup analysis tool.
Benjamin Rix Brooks, Erik P Pioro, Danielle Beaulieu, Albert A Taylor, Mark Schactman, Stephen Apple

Amyotroph Lateral Scler Frontotemporal Degener· February 2022

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Slowing the loss of physical function in amyotrophic lateral sclerosis with edaravone: Post hoc analysis of ALSFRS-R item scores in pivotal study MCI186-19.
Benjamin Rix Brooks, Erik P Pioro, Jonathan Katz, Fumihiro Takahashi, Koji Takei, Stephen Apple

Muscle Nerve· February 2022

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Current and Future Projections of Amyotrophic Lateral Sclerosis in the United States Using Administrative Claims Data.
Chris Miller, Stephen Apple, Jeremy S Paige, Tara Grabowsky, Oodaye Shukla

Neuroepidemiology· October 2021

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Radicava/Edaravone Findings in Biomarkers From Amyotrophic Lateral Sclerosis (REFINE-ALS): Protocol and Study Design.
James Berry, Benjamin Brooks, Angela Genge, Terry Heiman-Patterson, Stanley Appel, Stephen Apple

Neurol Clin Pract· August 2021

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Engaging ALS patients and caregivers (the ALS research ambassadors) to help design the REFINE-ALS biomarker study.
James D Berry, Richard Bedlack, Debra Mathews, Wendy Agnese, Stephen Apple

Amyotroph Lateral Scler Frontotemporal Degener· February 2021

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Clinical staging in amyotrophic lateral sclerosis: analysis of Edaravone Study 19.
Ammar Al-Chalabi, Adriano Chiò, Charlotte Merrill, Gerry Oster, Rebecca Bornheimer, Stephen Apple

J Neurol Neurosurg Psychiatry· February 2021

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Long-term edaravone efficacy in amyotrophic lateral sclerosis: Post-hoc analyses of Study 19 (MCI186-19).
Jeremy Shefner, Terry Heiman-Patterson, Erik P Pioro, Martina Wiedau-Pazos, Shawn Liu, Stephen Apple

Muscle Nerve· February 2020

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analyses of the edaravone clinical trials Study 16 and Study 19: a step toward more efficient clinical trial designs in amyotrophic lateral sclerosis.
Joseph M Palumbo, Jean Hubble, Stephen Apple, Koji Takei, Kikumi Tsuda

Amyotroph Lateral Scler Frontotemporal Degener· August 2019

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A new torsion pendulum for gravitational reference sensor technology development.
Giacomo Ciani, Andrew Chilton, Stephen Apple, Taiwo Olatunde, Michael Aitken

Rev Sci Instrum· June 2017

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