Publications by authors named "Stephen Ballaron"

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AAV2/6 Gene Therapy in a Murine Model of Fabry Disease Results in Supraphysiological Enzyme Activity and Effective Substrate Reduction.
Makiko Yasuda, Marshall W Huston, Silvere Pagant, Lin Gan, Susan St Martin, Stephen Ballaron

Mol Ther Methods Clin Dev· September 2020

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Novel Small Molecules Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein Protect Against Diverse α-Synuclein Mediated Dysfunctions.
Gergely Tóth, Thomas Neumann, Amandine Berthet, Eliezer Masliah, Brian Spencer, Stephen Ballaron

Sci Rep· November 2019

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Pyrrolidine-constrained phenethylamines: The design of potent, selective, and pharmacologically efficacious dipeptidyl peptidase IV (DPP4) inhibitors from a lead-like screening hit.
Bradley J Backes, Kenton Longenecker, Gregory L Hamilton, Kent Stewart, Chunqiu Lai, Stephen J Ballaron

Bioorg Med Chem Lett· April 2007

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Discovery and structure-activity relationships of piperidinone- and piperidine-constrained phenethylamines as novel, potent, and selective dipeptidyl peptidase IV inhibitors.
Zhonghua Pei, Xiaofeng Li, Thomas W von Geldern, Kenton Longenecker, Daisy Pireh, Stephen J Ballaron

J Med Chem· April 2007

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Xanthine mimetics as potent dipeptidyl peptidase IV inhibitors.
Ravi Kurukulasuriya, Jeffrey J Rohde, Bruce G Szczepankiewicz, Fatima Basha, Chunqui Lai, Stephen J Ballaron

Bioorg Med Chem Lett· December 2006

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Discovery of ((4R,5S)-5-amino-4-(2,4,5- trifluorophenyl)cyclohex-1-enyl)-(3- (trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone (ABT-341), a highly potent, selective, orally efficacious, and safe dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
Zhonghua Pei, Xiaofeng Li, Thomas W von Geldern, David J Madar, Kenton Longenecker, Stephen J Ballaron

J Med Chem· November 2006

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Discovery of 2-[4-{{2-(2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl]-2-oxoethyl]amino]- 4-methyl-1-piperidinyl]-4-pyridinecarboxylic acid (ABT-279): a very potent, selective, effective, and well-tolerated inhibitor of dipeptidyl peptidase-IV, useful for the treatment of diabetes.
David J Madar, Hana Kopecka, Daisy Pireh, Hong Yong, Zhonghua Pei, Stephen J Ballaron

J Med Chem· October 2006

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Discovery, structure-activity relationship, and pharmacological evaluation of (5-substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as potent dipeptidyl peptidase IV inhibitors.
Zhonghua Pei, Xiaofeng Li, Kenton Longenecker, Thomas W von Geldern, Paul E Wiedeman, Stephen J Ballaron

J Med Chem· June 2006

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Crystal structures of DPP-IV (CD26) from rat kidney exhibit flexible accommodation of peptidase-selective inhibitors.
Kenton L Longenecker, Kent D Stewart, David J Madar, Clarissa G Jakob, Elizabeth H Fry, Stephen J Ballaron

Biochemistry· June 2006

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Isoxazole carboxylic acids as protein tyrosine phosphatase 1B (PTP1B) inhibitors.
Hongyu Zhao, Gang Liu, Zhili Xin, Michael D Serby, Zhonghua Pei, Stephen J Ballaron

Bioorg Med Chem Lett· November 2004

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Identification of a monoacid-based, cell permeable, selective inhibitor of protein tyrosine phosphatase 1B.
Zhili Xin, Gang Liu, Cele Abad-Zapatero, Zhonghua Pei, Bruce G Szczepankiewicz, Stephen J Ballaron

Bioorg Med Chem Lett· November 2003

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Discovery and SAR of novel, potent and selective protein tyrosine phosphatase 1B inhibitors.
Zhonghua Pei, Xiaofeng Li, Gang Liu, Cele Abad-Zapatero, Tom Lubben, Stephen J Ballaron

Bioorg Med Chem Lett· October 2003

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Fragment screening and assembly: a highly efficient approach to a selective and cell active protein tyrosine phosphatase 1B inhibitor.
Gang Liu, Zhili Xin, Zhonghua Pei, Philip J Hajduk, Cele Abad-Zapatero, Stephen J Ballaron

J Med Chem· September 2003

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Selective protein tyrosine phosphatase 1B inhibitors: targeting the second phosphotyrosine binding site with non-carboxylic acid-containing ligands.
Gang Liu, Zhili Xin, Heng Liang, Cele Abad-Zapatero, Philip J Hajduk, Stephen J Ballaron

J Med Chem· July 2003

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Discovery of a potent, selective protein tyrosine phosphatase 1B inhibitor using a linked-fragment strategy.
Bruce G Szczepankiewicz, Gang Liu, Philip J Hajduk, Cele Abad-Zapatero, Zhonghua Pei, Stephen J Ballaron

J Am Chem Soc· April 2003

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TH1 and TH2 cytokine inhibition by 3,5-bis(trifluoromethyl)pyrazoles, a novel class of immunomodulators.
Yung- Wu Chen, Morey L Smith, Grace X Chiou, Stephen Ballaron, Michael P Sheets

Cell Immunol· December 2002

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