Publications by authors named "Stephen D Dertinger"

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Erythrocyte-Based Pig-a Gene Mutation Assay.
Jeffrey C Bemis, Nikki E Hall, Stephen D Dertinger

Methods Mol Biol· November 2025

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Critical Evaluation of Methods for the Identification of Aneugens.
Xiaowen Sun, Stephen D Dertinger, Azeddine Elhajouji, Daniel J Roberts, Jan van Benthem

Environ Mol Mutagen· October 2025

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Persistent interferon signaling and clonal expansion mark early events in DNA methylation damage-induced liver cancer.
Lee J Pribyl, Jennifer E Kay, Joshua J Corrigan, Lindsay B Volk, Monét Norales, Stephen D Dertinger

bioRxiv· October 2025

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Application of Biological Modifiers to a Multiplexed, Human Cell-Based DNA Damage Assay Provides Mechanistic Information on Genotoxicity and Molecular Targets.
Steven M Bryce, Svetlana L Avlasevich, Adam Conrad, Nikki E Hall, Kyle Tichenor, Stephen D Dertinger

Environ Mol Mutagen· June 2025

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Sex and Alkyladenine DNA Glycosylase Expression are Key Susceptibility Factors for NDMA-induced Mutations, Toxicity, and Cancer.
Jennifer E Kay, Joshua J Corrigan, Lindsay B Volk, Amanda L Armijo, Ilana S Nazari, Stephen D Dertinger

bioRxiv· May 2025

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Mitigation of Volatile Chemicals' Effect on Adjacent Microtiter Plate Wells.
Svetlana L Avlasevich, Erica Briggs, Kyle Tichenor, Adam Conrad, Nikki Hall, Stephen D Dertinger

Environ Mol Mutagen· March 2025

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Synthesizing Genotoxicity Results in the MultiFlow Assay With Point-of-Departure Analysis and ToxPi Visualization Techniques.
Yusuf Hussien, Stephen D Dertinger, George E Johnson

Environ Mol Mutagen· March 2025

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Visualization strategies to aid interpretation of high-dimensional genotoxicity data.
Stephen D Dertinger, Erica Briggs, Yusuf Hussien, Steven M Bryce, Svetlana L Avlasevich

Environ Mol Mutagen· June 2024

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Assessing the quality and making appropriate use of historical negative control data: A report of the International Workshop on Genotoxicity Testing (IWGT).
Stephen D Dertinger, Dingzhou Li, Carol Beevers, George R Douglas, Robert H Heflich

Environ Mol Mutagen· April 2023

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Lack of hydroxyurea-associated mutagenesis in pediatric sickle cell disease patients.
Dorothea K Torous, Svetlana Avlasevich, Jeffrey C Bemis, Thad Howard, Russell E Ware, Stephen D Dertinger

Environ Mol Mutagen· March 2023

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Quantitative in vitro to in vivo extrapolation of genotoxicity data provides protective estimates of in vivo dose.
Marc A Beal, Marc Audebert, Tara Barton-Maclaren, Hannah Battaion, Jeffrey C Bemis, Stephen D Dertinger

Environ Mol Mutagen· February 2023

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In vitro human cell-based aneugen molecular mechanism assay.
Nikki E Hall, Kyle Tichenor, Steven M Bryce, Jeffrey C Bemis, Stephen D Dertinger

Environ Mol Mutagen· March 2022

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Absence of hydroxyurea-induced mutational effects supports higher utilisation for the treatment of sickle cell anaemia.
Russell E Ware, Stephen D Dertinger

Br J Haematol· July 2021

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Kinetics of γH2AX and phospho-histone H3 following pulse treatment of TK6 cells provides insights into clastogenic activity.
Steven M Bryce, Stephen D Dertinger, Jeffrey C Bemis

Mutagenesis· July 2021

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The use of benchmark dose uncertainty measurements for robust comparative potency analyses.
Ryan P Wheeldon, Stephen D Dertinger, Steven M Bryce, Jeffrey C Bemis, George E Johnson

Environ Mol Mutagen· March 2021

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Recommendations for conducting the rodent erythrocyte Pig-a assay: A report from the HESI GTTC Pig-a Workgroup.
Stephen D Dertinger, Javed A Bhalli, Daniel J Roberts, Leon F Stankowski, B Bhaskar Gollapudi

Environ Mol Mutagen· March 2021

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Excision of mutagenic replication-blocking lesions suppresses cancer but promotes cytotoxicity and lethality in nitrosamine-exposed mice.
Jennifer E Kay, Joshua J Corrigan, Amanda L Armijo, Ilana S Nazari, Ishwar N Kohale, Stephen D Dertinger

Cell Rep· March 2021

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There's safety in numbers.
Russell E Ware, Stephen D Dertinger

Blood· February 2021

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Assessment of systemic genetic damage in pediatric inflammatory bowel disease.
Ayesha Baig, Svetlana L Avlasevich, Dorothea K Torous, Jeffrey C Bemis, Lawrence J Saubermann, Stephen D Dertinger

Environ Mol Mutagen· November 2020

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Human blood PIG-A mutation and micronucleated reticulocyte flow cytometric assays: Method optimization and evaluation of intra- and inter-subject variation.
Dorothea K Torous, Svetlana L Avlasevich, Mona G Khattab, Ayesha Baig, Lawrence J Saubermann, Stephen D Dertinger

Environ Mol Mutagen· October 2020

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Pig-a gene mutation assay study design: critical assessment of 3- versus 28-day repeat-dose treatment schedules.
Azeddine Elhajouji, Tamsanqa Tafara Hove, Oliver O'Connell, Hansjoerg Martus, Stephen D Dertinger

Mutagenesis· September 2020

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Intra- and inter-laboratory reproducibility of the rat blood Pig-a gene mutation assay.
Stephen D Dertinger, Svetlana L Avlasevich, Dorothea K Torous, Jeffrey C Bemis, Tamsanqa Tafara Hove

Environ Mol Mutagen· June 2020

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Benchmark Dose Analysis of DNA Damage Biomarker Responses Provides Compound Potency and Adverse Outcome Pathway Information for the Topoisomerase II Inhibitor Class of Compounds.
Ryan P Wheeldon, Derek T Bernacki, Stephen D Dertinger, Steven M Bryce, Jeffrey C Bemis

Environ Mol Mutagen· April 2020

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3Rs-friendly approach to exogenous metabolic activation that supports high-throughput genetic toxicology testing.
Shuchang Tian, Aiyana Cyr, Karen Zeise, Steven M Bryce, Nikki Hall, Stephen D Dertinger

Environ Mol Mutagen· April 2020

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Dextran sulfate sodium mouse model of inflammatory bowel disease evaluated for systemic genotoxicity via blood micronucleus and Pig-a gene mutation assays.
Christopher Kirby, Ayesha Baig, Svetlana L Avlasevich, Dorothea K Torous, Shuchang Tian, Stephen D Dertinger

Mutagenesis· March 2020

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