Publications by authors named "Stephen Gavalas"

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Optimization of potency and pharmacokinetics of tricyclic indole derived inhibitors of HCV NS5B polymerase. Identification of ester prodrugs with improved oral pharmacokinetics.
Srikanth Venkatraman, Francisco Velazquez, Stephen Gavalas, Wanli Wu, Kevin X Chen

Bioorg Med Chem· January 2014

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Discovery of an irreversible HCV NS5B polymerase inhibitor.
Qingbei Zeng, Anilkumar G Nair, Stuart B Rosenblum, Hsueh-Cheng Huang, Charles A Lesburg, Stephen Gavalas

Bioorg Med Chem Lett· December 2013

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Discovery of novel tricyclic indole derived inhibitors of HCV NS5B RNA dependent RNA polymerase.
Srikanth Venkatraman, Francisco Velazquez, Stephen Gavalas, Wanli Wu, Kevin X Chen

Bioorg Med Chem· April 2013

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Synthesis and SAR of geminal substitutions at the C5' carbosugar position of pyrimidine-derived HCV inhibitors.
Vishal A Verma, Randall Rossman, Frank Bennett, Lei Chen, Stephen Gavalas

Bioorg Med Chem Lett· November 2012

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Synthesis and SAR of pyridothiazole substituted pyrimidine derived HCV replication inhibitors.
Vinay M Girijavallabhan, Carmen Alvarez, Frank Bennett, Lei Chen, Stephen Gavalas

Bioorg Med Chem Lett· September 2012

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5-Benzothiazole substituted pyrimidine derivatives as HCV replication (replicase) inhibitors.
Ashok Arasappan, Frank Bennett, Vinay Girijavallabhan, Yuhua Huang, Regina Huelgas, Stephen Gavalas

Bioorg Med Chem Lett· May 2012

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A novel class of highly potent irreversible hepatitis C virus NS5B polymerase inhibitors.
Kevin X Chen, Charles A Lesburg, Bancha Vibulbhan, Weiying Yang, Tin-Yau Chan, Stephen Gavalas

J Med Chem· March 2012

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II. Novel HCV NS5B polymerase inhibitors: discovery of indole C2 acyl sulfonamides.
Gopinadhan N Anilkumar, Oleg Selyutin, Stuart B Rosenblum, Qingbei Zeng, Yueheng Jiang, Stephen Gavalas

Bioorg Med Chem Lett· January 2012

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Structure-activity relationship (SAR) development and discovery of potent indole-based inhibitors of the hepatitis C virus (HCV) NS5B polymerase.
Kevin X Chen, Bancha Vibulbhan, Weiying Yang, Mousumi Sannigrahi, Francisco Velazquez, Stephen Gavalas

J Med Chem· January 2012

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I. Novel HCV NS5B polymerase inhibitors: discovery of indole 2-carboxylic acids with C3-heterocycles.
Gopinadhan N Anilkumar, Charles A Lesburg, Oleg Selyutin, Stuart B Rosenblum, Qingbei Zeng, Stephen Gavalas

Bioorg Med Chem Lett· September 2011

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