Publications by authors named "Stephen Haggarty"

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Discovery of Small Molecules and a Druggable Groove That Regulate DNA Binding and Release of the AP-1 Transcription Factor ΔFOSB.
Sean McNeme, Yun Young Yim, Ashwani Kumar, Yi Li, Brandon Hughes, Stephen J Haggarty

J Biol Chem· December 2025

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Discovery of Small Molecules and a Druggable Groove That Regulate DNA Binding and Release of the AP1 Transcription Factor ΔFOSB.
Sean McNeme, Yun Young Yim, Ashwani Kumar, Yi Li, Brandon Hughes, Stephen J Haggarty

bioRxiv· October 2025

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Deep learning enhanced deciphering of brain activity maps for discovery of therapeutics for brain disorders.
Xianrui Zhang, Zhen Liu, Xuan Luo, Yi Cao, Wencong Zhang, Stephen J Haggarty

iScience· July 2025

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Splicing Modulators as a Therapeutic Strategy for Tauopathies.
M Catarina Silva, Hannah Lindmeier, Paolo Pigini, Jennifer Laughlin, Yong Yu, Stephen J Haggarty

bioRxiv· May 2025

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Targeted protein degradation with bifunctional molecules as a novel therapeutic modality for Alzheimer's disease & beyond.
C Alexander Sandhof, Heide F B Murray, M Catarina Silva, Stephen J Haggarty

Neurotherapeutics· April 2025

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Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing.
Cyril Pottier, Fahri Küçükali, Matt Baker, Anthony Batzler, Gregory D Jenkins, Stephen J Haggarty

Nat Commun· April 2025

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Few-shot meta-learning applied to whole brain activity maps improves systems neuropharmacology and drug discovery.
Xuan Luo, Yanyun Ding, Yi Cao, Zhen Liu, Wenchong Zhang, Stephen J Haggarty

iScience· October 2024

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Benzoxazole-derivatives enhance progranulin expression and reverse the aberrant lysosomal proteome caused by GRN haploinsufficiency.
Rachel Tesla, Charlotte Guhl, Gordon C Werthmann, Danielle Dixon, Basar Cenik, Stephen J Haggarty

Nat Commun· July 2024

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Deciphering Distinct Genetic Risk Factors for FTLD-TDP Pathological Subtypes via Whole-Genome Sequencing.
Cyril Pottier, Fahri Küçükali, Matt Baker, Anthony Batzler, Gregory D Jenkins, Stephen J Haggarty

medRxiv· June 2024

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Dissecting OGT's TPR domain to identify determinants of cellular function.
Sarah C Potter, Bettine E Gibbs, Forrest A Hammel, Cassandra M Joiner, Joao A Paulo, Stephen J Haggarty

Proc Natl Acad Sci U S A· May 2024

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Epigenetic modulation through BET bromodomain inhibitors as a novel therapeutic strategy for progranulin-deficient frontotemporal dementia.
Zachary C Rosenthal, Daniel M Fass, N Connor Payne, Angela She, Debasis Patnaik, Stephen J Haggarty

Sci Rep· April 2024

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Bipolar disorder-iPSC derived neural progenitor cells exhibit dysregulation of store-operated Ca entry and accelerated differentiation.
Tristen Hewitt, Begüm Alural, Manali Tilak, Jennifer Wang, Natalina Becke, Stephen J Haggarty

Mol Psychiatry· December 2023

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Cholesterol Dysregulation Drives Seed-Dependent Tau Aggregation in Patient Stem Cell-Derived Models of Tauopathy.
Morrie Lam, Szu-Yu Kuo, Surya Reis, Jason E Gestwicki, M Catarina Silva, Stephen J Haggarty

bioRxiv· December 2023

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Small molecule regulators of microRNAs identified by high-throughput screen coupled with high-throughput sequencing.
Lien D Nguyen, Zhiyun Wei, M Catarina Silva, Sergio Barberán-Soler, Jiarui Zhang, Stephen J Haggarty

Nat Commun· November 2023

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Improved Protocol for Reproducible Human Cortical Organoids Reveals Early Alterations in Metabolism with Mutations.
Taylor Bertucci, Kathryn R Bowles, Steven Lotz, Le Qi, Katherine Stevens, Stephen J Haggarty

bioRxiv· July 2023

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A Cdk5-derived peptide inhibits Cdk5/p25 activity and improves neurodegenerative phenotypes.
Ping-Chieh Pao, Jinsoo Seo, Audrey Lee, Oleg Kritskiy, Debasis Patnaik, Stephen J Haggarty

Proc Natl Acad Sci U S A· April 2023

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A prolyl oligopeptidase inhibitor reduces tau pathology in cellular models and in mice with tauopathy.
Tony S Eteläinen, M Catarina Silva, Johanna K Uhari-Väänänen, Francesca De Lorenzo, Maria H Jäntti, Stephen J Haggarty

Sci Transl Med· April 2023

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Small Molecule Regulators of microRNAs Identified by High-Throughput Screen Coupled with High-Throughput Sequencing.
Anna Krichevsky, Lien Nguyen, Zhiyun Wei, M Silva, Sergio Barberán-Soler, Stephen Haggarty

Res Sq· March 2023

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Chemically targeting the redox switch in AP1 transcription factor ΔFOSB.
Ashwani Kumar, Galina Aglyamova, Yun Young Yim, Aaron O Bailey, Haley M Lynch, Stephen J Haggarty

Nucleic Acids Res· September 2022

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Brain-specific deletion of GIT1 impairs cognition and alters phosphorylation of synaptic protein networks implicated in schizophrenia susceptibility.
Daniel M Fass, Michael C Lewis, Rushdy Ahmad, Matthew J Szucs, Qiangge Zhang, Stephen J Haggarty

Mol Psychiatry· August 2022

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Differentiation of Human Induced Pluripotent Stem Cells into Cortical Neurons to Advance Precision Medicine.
M Catarina Silva, Ghata Nandi, Stephen J Haggarty

Methods Mol Biol· May 2022

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Discovery and Optimization of Tau Targeted Protein Degraders Enabled by Patient Induced Pluripotent Stem Cells-Derived Neuronal Models of Tauopathy.
M Catarina Silva, Ghata Nandi, Katherine A Donovan, Quan Cai, Bethany C Berry, Stephen J Haggarty

Front Cell Neurosci· March 2022

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Targeting Tau Mitigates Mitochondrial Fragmentation and Oxidative Stress in Amyotrophic Lateral Sclerosis.
Tiziana Petrozziello, Evan A Bordt, Alexandra N Mills, Spencer E Kim, Ellen Sapp, Stephen J Haggarty

Mol Neurobiol· January 2022

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A bidirectional competitive interaction between circHomer1 and Homer1b within the orbitofrontal cortex regulates reversal learning.
Alexander K Hafez, Amber J Zimmerman, Grigorios Papageorgiou, Jayapriya Chandrasekaran, Stephen K Amoah, Stephen J Haggarty

Cell Rep· January 2022

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Zinc-dependent histone deacetylases drive neutrophil extracellular trap formation and potentiate local and systemic inflammation.
Valentina Poli, Victor Pui-Yan Ma, Marco Di Gioia, Achille Broggi, Mehdi Benamar, Stephen J Haggarty

iScience· November 2021

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