Publications by authors named "Stephen J Demarest"

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Ucenprubart is an agonistic antibody to CD200R with the potential to treat inflammatory skin disease: preclinical development and a phase 1 clinical study.
Anja Koester, Derrick R Witcher, Mark Lee, Stephen J Demarest, Scott Potter

Nat Commun· May 2025

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Engineering a tumor-selective prodrug T-cell engager bispecific antibody for safer immunotherapy.
Amelia C McCue, Stephen J Demarest, Karen J Froning, Michael J Hickey, Stephen Antonysamy

MAbs· July 2024

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Generalizable design parameters for soluble T cell receptor-based T cell engagers.
Karen J Froning, Arlene Sereno, Flora Huang, Stephen J Demarest

J Immunother Cancer· March 2022

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Computational stabilization of T cell receptors allows pairing with antibodies to form bispecifics.
Karen Froning, Jack Maguire, Arlene Sereno, Flora Huang, Shawn Chang, Stephen J Demarest

Nat Commun· May 2020

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Building blocks for bispecific and trispecific antibodies.
Xiufeng Wu, Stephen J Demarest

Methods· February 2019

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Generation of orthogonal Fab-based trispecific antibody formats.
Xiufeng Wu, Richard Yuan, Michael Bacica, Stephen J Demarest

Protein Eng Des Sel· July 2018

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Glycosylation Profiling of α/β T Cell Receptor Constant Domains Expressed in Mammalian Cells.
Kai Zhang, Stephen J Demarest, Xiufeng Wu, Jonathan R Fitchett

Methods Mol Biol· February 2018

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Transient and stable CHO expression, purification and characterization of novel hetero-dimeric bispecific IgG antibodies.
Yashas Rajendra, Robert B Peery, Maria D Hougland, Gavin C Barnard, Xiufeng Wu, Stephen J Demarest

Biotechnol Prog· March 2017

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Comparing domain interactions within antibody Fabs with kappa and lambda light chains.
Raheleh Toughiri, Xiufeng Wu, Diana Ruiz, Flora Huang, John W Crissman, Stephen J Demarest

MAbs· October 2016

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Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Andrew Leaver-Fay, Karen J Froning, Shane Atwell, Hector Aldaz, Anna Pustilnik, Stephen J Demarest

Structure· April 2016

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Fab-based bispecific antibody formats with robust biophysical properties and biological activity.
Xiufeng Wu, Arlene J Sereno, Flora Huang, Steven M Lewis, Ricky L Lieu, Stephen J Demarest

MAbs· March 2016

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Protein design of IgG/TCR chimeras for the co-expression of Fab-like moieties within bispecific antibodies.
Xiufeng Wu, Arlene J Sereno, Flora Huang, Kai Zhang, Micheal Batt, Stephen J Demarest

MAbs· November 2015

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Influence of canonical structure determining residues on antibody affinity and stability.
Louis A Clark, Stephen J Demarest, John Eldredge, Matthew B Jarpe, You Li

J Struct Biol· February 2014

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Generation of bispecific IgG antibodies by structure-based design of an orthogonal Fab interface.
Steven M Lewis, Xiufeng Wu, Anna Pustilnik, Arlene Sereno, Flora Huang, Stephen J Demarest

Nat Biotechnol· February 2014

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Highly covarying residues have a functional role in antibody constant domains.
Elizabeth A Proctor, Pradeep Kota, Stephen J Demarest, Justin A Caravella, Nikolay V Dokholyan

Proteins· May 2013

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Evaluation of Tyro3 expression, Gas6-mediated Akt phosphorylation, and the impact of anti-Tyro3 antibodies in melanoma cell lines.
Stephen J Demarest, Jennifer Gardner, Michelle C Vendel, Eric Ailor, Suzanne Szak

Biochemistry· May 2013

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Metric to distinguish closely related domain families using sequence information.
Elizabeth A Proctor, Pradeep Kota, Stephen J Demarest, Justin A Caravella, Nikolay V Dokholyan

J Mol Biol· February 2013

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Secretion from bacterial versus mammalian cells yields a recombinant scFv with variable folding properties.
Michelle C Vendel, Michael Favis, William B Snyder, Flora Huang, Allan D Capili, Stephen J Demarest

Arch Biochem Biophys· October 2012

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Emerging antibody combinations in oncology.
Stephen J Demarest, Kandasamy Hariharan, Jianying Dong

MAbs· January 2012

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A stable IgG-like bispecific antibody targeting the epidermal growth factor receptor and the type I insulin-like growth factor receptor demonstrates superior anti-tumor activity.
Jianying Dong, Arlene Sereno, Dikran Aivazian, Emma Langley, Brian R Miller, Stephen J Demarest

MAbs· December 2011

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Neutralization of Clostridium difficile toxin A using antibody combinations.
Stephen J Demarest, Mangala Hariharan, Marikka Elia, Jared Salbato, Ping Jin

MAbs· July 2011

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Fine details of IGF-1R activation, inhibition, and asymmetry determined by associated hydrogen /deuterium-exchange and peptide mass mapping.
Damian Houde, Stephen J Demarest

Structure· June 2011

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Stable IgG-like bispecific antibodies directed toward the type I insulin-like growth factor receptor demonstrate enhanced ligand blockade and anti-tumor activity.
Jianying Dong, Arlene Sereno, William B Snyder, Brian R Miller, Susan Tamraz, Stephen J Demarest

J Biol Chem· February 2011

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Combination of two insulin-like growth factor-I receptor inhibitory antibodies targeting distinct epitopes leads to an enhanced antitumor response.
Jianying Dong, Stephen J Demarest, Arlene Sereno, Susan Tamraz, Emma Langley

Mol Cancer Ther· September 2010

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Stability engineering of scFvs for the development of bispecific and multivalent antibodies.
Brian R Miller, Stephen J Demarest, Alexey Lugovskoy, Flora Huang, Xiufeng Wu

Protein Eng Des Sel· July 2010

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