Publications by authors named "Stephen L Lessnick"

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DBD-α4 helix of EWSR1::FLI1 is required for GGAA microsatellite binding that underlies genome regulation in Ewing sarcoma.
Ariunaa Bayanjargal, Cenny Taslim, Iftekhar A Showpnil, Julia Selich-Anderson, Jesse C Crow, Stephen L Lessnick

bioRxiv· June 2024

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Randomized Phase III Trial of Ganitumab With Interval-Compressed Chemotherapy for Patients With Newly Diagnosed Metastatic Ewing Sarcoma: A Report From the Children's Oncology Group.
Steven G DuBois, Mark D Krailo, Julia Glade-Bender, Allen Buxton, Nadia Laack, Stephen L Lessnick

J Clin Oncol· April 2023

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The ETS transcription factor ETV6 constrains the transcriptional activity of EWS-FLI to promote Ewing sarcoma.
Diana Y Lu, Jana M Ellegast, Kenneth N Ross, Clare F Malone, Shan Lin, Stephen L Lessnick

Nat Cell Biol· February 2023

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Adverse prognostic impact of the loss of STAG2 protein expression in patients with newly diagnosed localised Ewing sarcoma: A report from the Children's Oncology Group.
David S Shulman, Sonja Chen, David Hall, Anwesha Nag, Aaron R Thorner, Stephen L Lessnick

Br J Cancer· December 2022

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An international working group consensus report for the prioritization of molecular biomarkers for Ewing sarcoma.
David S Shulman, Sarah B Whittle, Didier Surdez, Kelly M Bailey, Enrique de Álava, Stephen L Lessnick

NPJ Precis Oncol· September 2022

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EWS/FLI mediated reprogramming of 3D chromatin promotes an altered transcriptional state in Ewing sarcoma.
Iftekhar A Showpnil, Julia Selich-Anderson, Cenny Taslim, Megann A Boone, Jesse C Crow, Stephen L Lessnick

Nucleic Acids Res· September 2022

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Mitochondrial Dysfunction Is a Driver of SP-2509 Drug Resistance in Ewing Sarcoma.
E John Tokarsky, Jesse C Crow, Lillian M Guenther, John Sherman, Cenny Taslim, Stephen L Lessnick

Mol Cancer Res· July 2022

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Patterns of Translocation Testing in Patients Enrolling in a Cooperative Group Trial for Newly Diagnosed Metastatic Ewing Sarcoma.
Steven G DuBois, Mark D Krailo, Allen Buxton, Stephen L Lessnick, Lisa A Teot

Arch Pathol Lab Med· December 2021

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Identification of a Novel Fusion and Comparative Analysis with Other Ewing Sarcoma Fusion Proteins.
Megann A Boone, Cenny Taslim, Jesse C Crow, Julia Selich-Anderson, Mike Watson, Stephen L Lessnick

Mol Cancer Res· November 2021

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Network potential identifies therapeutic miRNA cocktails in Ewing sarcoma.
Davis T Weaver, Kathleen I Pishas, Drew Williamson, Jessica Scarborough, Stephen L Lessnick

PLoS Comput Biol· October 2021

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The FLI portion of EWS/FLI contributes a transcriptional regulatory function that is distinct and separable from its DNA-binding function in Ewing sarcoma.
Megann A Boone, Cenny Taslim, Jesse C Crow, Julia Selich-Anderson, Andrea K Byrum, Stephen L Lessnick

Oncogene· July 2021

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Chromatin profiling reveals relocalization of lysine-specific demethylase 1 by an oncogenic fusion protein.
Emily R Theisen, Julia Selich-Anderson, Kyle R Miller, Jason M Tanner, Cenny Taslim, Stephen L Lessnick

Epigenetics· April 2021

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Survey of Paediatric Oncologists and Pathologists regarding Their Views and Experiences with Variant Translocations in Ewing and Ewing-Like Sarcoma: A Report of the Children's Oncology Group.
Michael D Kinnaman, Chong Zhu, Daniel A Weiser, Sana Mohiuddin, Pooja Hingorani, Stephen L Lessnick

Sarcoma· December 2020

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Identifying States of Collateral Sensitivity during the Evolution of Therapeutic Resistance in Ewing's Sarcoma.
Jessica A Scarborough, Erin McClure, Peter Anderson, Andrew Dhawan, Arda Durmaz, Stephen L Lessnick

iScience· July 2020

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Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis.
Iftekhar A Showpnil, Kyle R Miller, Cenny Taslim, Kathleen I Pishas, Stephen L Lessnick

J Vis Exp· June 2020

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Protein phosphatase 1 regulatory subunit 1A regulates cell cycle progression in Ewing sarcoma.
Wen Luo, Changxin Xu, Sarah Phillips, Aliza Gardenswartz, Jeremy M Rosenblum, Stephen L Lessnick

Oncotarget· May 2020

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High-Dose Chemotherapy Compared With Standard Chemotherapy and Lung Radiation in Ewing Sarcoma With Pulmonary Metastases: Results of the European Ewing Tumour Working Initiative of National Groups, 99 Trial and EWING 2008.
Uta Dirksen, Bernadette Brennan, Marie-Cécile Le Deley, Nathalie Cozic, Henk van den Berg, Stephen L Lessnick

J Clin Oncol· December 2019

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Increased risk for other cancers in individuals with Ewing sarcoma and their relatives.
Diana Abbott, Schuyler O'Brien, James M Farnham, Erin L Young, Jeffrey Yap, Stephen L Lessnick

Cancer Med· December 2019

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Trabectedin Inhibits EWS-FLI1 and Evicts SWI/SNF from Chromatin in a Schedule-dependent Manner.
Matt L Harlow, Maggie H Chasse, Elissa A Boguslawski, Katie M Sorensen, Jenna M Gedminas, Stephen L Lessnick

Clin Cancer Res· June 2019

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Investigating the role of LSD2 as an epigenetic regulator in Ewing sarcoma.
Priyal O Patel, Kathleen I Pishas, Cenny Taslim, Julia Selich-Anderson, Emily R Theisen, Stephen L Lessnick

Oncotarget· June 2019

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Correction: Detection of circulating tumour DNA is associated with inferior outcomes in Ewing sarcoma and osteosarcoma: a report from the Children's Oncology Group.
David S Shulman, Kelly Klega, Alma Imamovic-Tuco, Andrea Clapp, Anwesha Nag, Stephen L Lessnick

Br J Cancer· April 2019

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Survival and prognosis with osteosarcoma: outcomes in more than 2000 patients in the EURAMOS-1 (European and American Osteosarcoma Study) cohort.
Sigbjørn Smeland, Stefan S Bielack, Jeremy Whelan, Mark Bernstein, Pancras Hogendoorn, Stephen L Lessnick

Eur J Cancer· March 2019

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Transcriptomic analysis functionally maps the intrinsically disordered domain of EWS/FLI and reveals novel transcriptional dependencies for oncogenesis.
Emily R Theisen, Kyle R Miller, Iftekhar A Showpnil, Cenny Taslim, Kathleen I Pishas, Stephen L Lessnick

Genes Cancer· February 2019

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Ewing sarcoma resistance to SP-2509 is not mediated through KDM1A/LSD1 mutation.
Kathleen I Pishas, Stephen L Lessnick

Oncotarget· November 2018

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Detection of circulating tumour DNA is associated with inferior outcomes in Ewing sarcoma and osteosarcoma: a report from the Children's Oncology Group.
David S Shulman, Kelly Klega, Alma Imamovic-Tuco, Andrea Clapp, Anwesha Nag, Stephen L Lessnick

Br J Cancer· August 2018

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