Publications by authors named "Stephen Lockett"

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Lamin A/C loss promotes R-loop-mediated genomic instability and poor survival in small-cell lung cancer.
Christopher W Schultz, Sourav Saha, Anjali Dhall, Yang Zhang, Parth Desai, Stephen Lockett

Proc Natl Acad Sci U S A· October 2025

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Elevated tumor NOS2/COX2 promotes immunosuppressive phenotypes associated with poor survival in ER- breast cancer.
Lisa A Ridnour, Robert Ys Cheng, William F Heinz, Milind Pore, Ana L Gonzalez, Stephen J Lockett

JCI Insight· August 2025

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TRAIL induces cytokine production via the NFkB2 pathway promoting neutrophil chemotaxis and neutrophil-mediated immune-suppression in triple negative breast cancer cells.
Manjari Kundu, Yoshimi E Greer, Alexei Lobanov, Lisa Ridnour, Renee N Donahue, Stephen J Lockett

Cancer Lett· June 2025

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Nuclear-Free Zoning.
Stephen Lockett, Andrew Weisman

Cytometry A· June 2025

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Lamin A/C Deficiency Drives Genomic Instability and Poor Survival in Small-Cell Lung Cancer through Increased R-loop Accumulation.
Christopher W Schultz, Sourav Saha, Anjali Dhall, Yang Zhang, Parth Desai, Stephen Lockett

bioRxiv· May 2025

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SPAC: a scalable, integrated enterprise platform for end-to-end single cell spatial analysis of multiplexed tissue imaging.
Fang Liu, Rui He, Thomas Sheeley, David Scheiblin, Stephen J Lockett

bioRxiv· April 2025

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NOS inhibition sensitizes metaplastic breast cancer to PI3K inhibition and taxane therapy via c-JUN repression.
Tejaswini Reddy, Akshjot Puri, Liliana Guzman-Rojas, Christoforos Thomas, Wei Qian, Stephen Lockett

Nat Commun· December 2024

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Tumor NOS2 and COX2 Spatial Juxtaposition with CD8+ T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER- Breast Cancer.
Lisa A Ridnour, William F Heinz, Robert Y S Cheng, Adelaide L Wink, Noemi Kedei, Stephen J Lockett

Cancer Res Commun· October 2024

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TRAIL-induced cytokine production via NFKB2 pathway promotes neutrophil chemotaxis and immune suppression in triple negative breast cancers.
Manjari Kundu, Yoshimi E Greer, Alexei Lobanov, Lisa Ridnour, Renee N Donahue, Stephen J Lockett

bioRxiv· July 2024

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NOS2 and COX-2 Co-Expression Promotes Cancer Progression: A Potential Target for Developing Agents to Prevent or Treat Highly Aggressive Breast Cancer.
Leandro L Coutinho, Elise L Femino, Ana L Gonzalez, Rebecca L Moffat, William F Heinz, Stephen J Lockett

Int J Mol Sci· June 2024

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Adjuvant COX inhibition augments STING signaling and cytolytic T cell infiltration in irradiated 4T1 tumors.
Lisa A Ridnour, Robert Ys Cheng, Noemi Kedei, Veena Somasundaram, Dibyangana D Bhattacharyya, Stephen J Lockett

JCI Insight· May 2024

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NOS2 and COX2 Provide Key Spatial Targets that Determine Outcome in ER- Breast Cancer.
Lisa A Ridnour, William F Heinz, Robert Ys Cheng, Adelaide L Wink, Noemi Kedei, Stephen J Lockett

bioRxiv· December 2023

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Spatial analysis of NOS2 and COX2 interaction with T-effector cells reveals immunosuppressive landscapes associated with poor outcome in ER- breast cancer patients.
Lisa A Ridnour, Robert Y S Cheng, William F Heinz, Milind Pore, Ana L Gonzalez, Stephen J Lockett

bioRxiv· December 2023

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Interferon-gamma is quintessential for NOS2 and COX2 expression in ER breast tumors that lead to poor outcome.
Robert Y S Cheng, Lisa A Ridnour, Adelaide L Wink, Ana L Gonzalez, Elise L Femino, Stephen J Lockett

Cell Death Dis· May 2023

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Interferon-gamma is Quintessential for NOS2 and COX2 Expression in ER Breast Tumors that Lead to Poor Outcome.
Robert Ys Cheng, Lisa A Ridnour, Adelaide L Wink, Ana L Gonzalez, Elise L Femino, Stephen J Lockett

bioRxiv· April 2023

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Visualizing and Quantifying mRNA Localization at the Invasive Front of 3D Cancer Spheroids.
Konstadinos Moissoglu, Stephen J Lockett, Stavroula Mili

Methods Mol Biol· January 2023

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Systemic Nos2 Depletion and Cox inhibition limits TNBC disease progression and alters lymphoid cell spatial orientation and density.
Veena Somasundaram, Lisa A Ridnour, Robert Ys Cheng, Abigail J Walke, Noemi Kedei, Stephen J Lockett

Redox Biol· December 2022

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Profiling DNA damage in 3D Histology Samples.
Kristofer E Delas Peñas, Ralf Haeusler, Sally Feng, Valentin Magidson, Mariia Dmitrieva, Stephen Lockett

Med Opt Imaging Virtual Microsc Image Anal (2022)· September 2022

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Tumour irradiation combined with vascular-targeted photodynamic therapy enhances antitumour effects in pre-clinical prostate cancer.
Hanna T Sjoberg, Yiannis Philippou, Anette L Magnussen, Iain D C Tullis, Esther Bridges, Stephen J Lockett

Br J Cancer· August 2021

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Nitric Oxide Modulates Metabolic Processes in the Tumor Immune Microenvironment.
Christopher L McGinity, Erika M Palmieri, Veena Somasundaram, Dibyangana D Bhattacharyya, Lisa A Ridnour, Stephen J Lockett

Int J Mol Sci· June 2021

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An in vitro tumorigenesis model based on live-cell-generated oxygen and nutrient gradients.
Anne C Gilmore, Sarah J Flaherty, Veena Somasundaram, David A Scheiblin, Stephen J Lockett

Commun Biol· April 2021

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Synchronous RNA conformational changes trigger ordered phase transitions in crystals.
Saminathan Ramakrishnan, Jason R Stagno, Chelsie E Conrad, Jienyu Ding, Ping Yu, Stephen Lockett

Nat Commun· March 2021

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Collective cancer cell invasion requires RNA accumulation at the invasive front.
George Chrisafis, Tianhong Wang, Konstadinos Moissoglu, Alexander N Gasparski, Yeap Ng, Stephen J Lockett

Proc Natl Acad Sci U S A· November 2020

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Impacts of combining anti-PD-L1 immunotherapy and radiotherapy on the tumour immune microenvironment in a murine prostate cancer model.
Yiannis Philippou, Hanna T Sjoberg, Emma Murphy, Said Alyacoubi, Keaton I Jones, Stephen J Lockett

Br J Cancer· September 2020

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Id1 and Id3 Maintain Steady-State Hematopoiesis by Promoting Sinusoidal Endothelial Cell Survival and Regeneration.
Stephen Gadomski, Satyendra K Singh, Shweta Singh, Tanmoy Sarkar, Kimberly D Klarmann, Stephen Lockett

Cell Rep· April 2020

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