Publications by authors named "Stephen Morairty"

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Biological sex influences sleep phenotype in mice experiencing spontaneous opioid withdrawal.
Ryan K Tisdale, Yu Sun, Sunmee Park, Shun-Chieh Ma, Meghan Haire, Stephen R Morairty

J Sleep Res· May 2024

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Evaluation of the efficacy of the hypocretin/orexin receptor agonists TAK-925 and ARN-776 in narcoleptic orexin/tTA; TetO-DTA mice.
Yu Sun, Alok Ranjan, Ryan Tisdale, Shun-Chieh Ma, Sunmee Park, Stephen R Morairty

J Sleep Res· August 2023

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Publisher Correction to: Trace amine-associated receptor 1 agonism promotes wakefulness without impairment of cognition in Cynomolgus macaques.
Anushka V Goonawardena, Stephen R Morairty, Ryan Dell, Gabriel A Orellana, Marius C Hoener

Neuropsychopharmacology· August 2023

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Activation of the nociceptin/orphanin-FQ receptor promotes NREM sleep and EEG slow wave activity.
Stephen R Morairty, Yu Sun, Lawrence Toll, Michael R Bruchas, Thomas S Kilduff

Proc Natl Acad Sci U S A· March 2023

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The development of sleep/wake disruption and cataplexy as hypocretin/orexin neurons degenerate in male vs. female Orexin/tTA; TetO-DTA Mice.
Yu Sun, Ryan Tisdale, Sunmee Park, Shun-Chieh Ma, Jasmine Heu, Stephen R Morairty

Sleep· December 2022

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From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease.
Alastair J H Brown, Sophie J Bradley, Fiona H Marshall, Giles A Brown, Kirstie A Bennett, Stephen R Morairty

Cell· November 2021

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Acute cognitive effects of the hypocretin receptor antagonist almorexant relative to zolpidem and placebo: a randomized clinical trial.
Thomas C Neylan, Anne Richards, Thomas J Metzler, Leslie M Ruoff, Jonathan Varbel, Stephen R Morairty

Sleep· October 2020

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Trace amine-associated receptor 1 agonism promotes wakefulness without impairment of cognition in Cynomolgus macaques.
Anushka V Goonawardena, Stephen R Morairty, Ryan Dell, Gabriel A Orellana, Marius C Hoener

Neuropsychopharmacology· July 2019

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Validation of 'Somnivore', a Machine Learning Algorithm for Automated Scoring and Analysis of Polysomnography Data.
Giancarlo Allocca, Sherie Ma, Davide Martelli, Matteo Cerri, Flavia Del Vecchio, Stephen R Morairty

Front Neurosci· March 2019

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Electrophysiological characterization of sleep/wake, activity and the response to caffeine in adult cynomolgus macaques.
Anushka V Goonawardena, Stephen R Morairty, Gabriel A Orellana, Adrian R Willoughby, Tanya L Wallace

Neurobiol Sleep Circadian Rhythms· January 2019

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Trace Amine-Associated Receptor 1 Regulates Wakefulness and EEG Spectral Composition.
Michael D Schwartz, Sarah W Black, Simon P Fisher, Jeremiah B Palmerston, Stephen R Morairty

Neuropsychopharmacology· May 2017

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Locus Coeruleus and Tuberomammillary Nuclei Ablations Attenuate Hypocretin/Orexin Antagonist-Mediated REM Sleep.
Michael D Schwartz, Alexander T Nguyen, Deepti R Warrier, Jeremiah B Palmerston, Alexia M Thomas, Stephen R Morairty

eNeuro· December 2016

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The Dual Hypocretin Receptor Antagonist Almorexant is Permissive for Activation of Wake-Promoting Systems.
Gregory S Parks, Deepti R Warrier, Lars Dittrich, Michael D Schwartz, Jeremiah B Palmerston, Stephen R Morairty

Neuropsychopharmacology· March 2016

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Quantitative Electroencephalographic Analysis Provides an Early-Stage Indicator of Disease Onset and Progression in the zQ175 Knock-In Mouse Model of Huntington's Disease.
Simon P Fisher, Michael D Schwartz, Sarah Wurts-Black, Alexia M Thomas, Tsui-Ming Chen, Stephen R Morairty

Sleep· February 2016

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Pharmacology of basimglurant (RO4917523, RG7090), a unique metabotropic glutamate receptor 5 negative allosteric modulator in clinical development for depression.
Lothar Lindemann, Richard H Porter, Sebastian H Scharf, Basil Kuennecke, Andreas Bruns, Stephen R Morairty

J Pharmacol Exp Ther· April 2015

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Homeostatic sleep pressure is the primary factor for activation of cortical nNOS/NK1 neurons.
Lars Dittrich, Stephen R Morairty, Deepti R Warrier, Thomas S Kilduff

Neuropsychopharmacology· February 2015

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GABAB agonism promotes sleep and reduces cataplexy in murine narcolepsy.
Sarah Wurts Black, Stephen R Morairty, Tsui-Ming Chen, Andrew K Leung, Jonathan P Wisor

J Neurosci· May 2014

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The hypocretin/orexin antagonist almorexant promotes sleep without impairment of performance in rats.
Stephen R Morairty, Alan J Wilk, Webster U Lincoln, Thomas C Neylan, Thomas S Kilduff

Front Neurosci· February 2014

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A role for cortical nNOS/NK1 neurons in coupling homeostatic sleep drive to EEG slow wave activity.
Stephen R Morairty, Lars Dittrich, Ravi K Pasumarthi, Daniel Valladao, Jaime E Heiss

Proc Natl Acad Sci U S A· December 2013

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Longitudinal analysis of the electroencephalogram and sleep phenotype in the R6/2 mouse model of Huntington's disease.
Simon P Fisher, Sarah W Black, Michael D Schwartz, Alan J Wilk, Tsui-Ming Chen, Stephen R Morairty

Brain· July 2013

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Almorexant promotes sleep and exacerbates cataplexy in a murine model of narcolepsy.
Sarah Wurts Black, Stephen R Morairty, Simon P Fisher, Tsui-Ming Chen, Deepti R Warrier

Sleep· March 2013

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Trace amine-associated receptor 1 partial agonism reveals novel paradigm for neuropsychiatric therapeutics.
Florent G Revel, Jean-Luc Moreau, Raul R Gainetdinov, Antonio Ferragud, Clara Velázquez-Sánchez, Stephen R Morairty

Biol Psychiatry· December 2012

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Dual hypocretin receptor antagonism is more effective for sleep promotion than antagonism of either receptor alone.
Stephen R Morairty, Florent G Revel, Pari Malherbe, Jean-Luc Moreau, Daniel Valladao

PLoS One· November 2012

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The wake-promoting effects of hypocretin-1 are attenuated in old rats.
Stephen R Morairty, Jonathan Wisor, Kristy Silveira, William Sinko, Thomas S Kilduff

Neurobiol Aging· August 2011

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Discovery of 1-[3-(4-bromo-2-methyl-2h-pyrazol-3-yl)-4-methoxyphenyl]-3-(2,4-difluorophenyl)urea (nelotanserin) and related 5-hydroxytryptamine2A inverse agonists for the treatment of insomnia.
Bradley R Teegarden, Hongmei Li, Honnappa Jayakumar, Sonja Strah-Pleynet, Peter I Dosa, Stephen R Morairty

J Med Chem· March 2010

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