Publications by authors named "Stephen Neidle"

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Cellular adaptations impact the biological activity of naphthalene diimide G-quadruplex ligands in ALT-positive osteosarcoma cells.
Joanna Bidzinska, Lorenzo Di Pietro, Eisa Naghshineh, Cecilia Pandini, Filippo Doria, Stephen Neidle

Cell Death Dis· August 2025

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Structural and Functional Insights into Targeting GCCG Sites in the EGFR Promoter by Two DNA Intercalators to Inhibit Breast Cancer Metastasis.
Chih-Chun Chang, Hsin-Ju Li, Roshan Satange, Shan-Meng Lin, Tai-Lin Chen, Stephen Neidle

J Med Chem· March 2025

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Alternative Approach to Sequence-Specific Recognition of DNA: Cooperative Stacking of Dication Dimers─Sensitivity to Compound Curvature, Aromatic Structure, and DNA Sequence.
Ananya Paul, J Ross Terrell, Abdelbasset A Farahat, Edwin N Ogbonna, Arvind Kumar, Stephen Neidle

ACS Chem Biol· February 2025

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The G-quadruplex experimental drug QN-302 impairs liposarcoma cell growth by inhibiting MDM2 expression and restoring p53 levels.
Beatrice Tosoni, Eisa Naghshineh, Irene Zanin, Irene Gallina, Lorenzo Di Pietro, Stephen Neidle

Nucleic Acids Res· February 2025

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Interaction of N-methylmesoporphyrin IX with a hybrid left-/right-handed G-quadruplex motif from the promoter of the SLC2A1 gene.
Paul Seth, Eric Xing, Andrew D Hendrickson, Kevin Li, Robert Monsen, Stephen Neidle

Nucleic Acids Res· January 2025

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Structural basis of water-mediated cis Watson-Crick/Hoogsteen base-pair formation in non-CpG methylation.
Shan-Meng Lin, Hsiang-Ti Huang, Pei-Ju Fang, Chi-Fon Chang, Roshan Satange, Stephen Neidle

Nucleic Acids Res· August 2024

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A Phenotypic Approach to the Discovery of Potent G-Quadruplex Targeted Drugs.
Stephen Neidle

Molecules· August 2024

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Structure-activity relationships for the G-quadruplex-targeting experimental drug QN-302 and two analogues probed with comparative transcriptome profiling and molecular modeling.
Ahmed Abdullah Ahmed, Shuang Chen, Maria Roman-Escorza, Richard Angell, Sally Oxenford, Dan Neidle, Stephen Neidle

Sci Rep· February 2024

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On Water Arrangements in Right- and Left-Handed DNA Structures.
Liliya A Yatsunyk, Stephen Neidle

Molecules· January 2024

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QN-302 demonstrates opposing effects between i-motif and G-quadruplex DNA structures in the promoter of the S100P gene.
Effrosyni Alexandrou, Dilek Guneri, Stephen Neidle, Zoë A E Waller

Org Biomol Chem· December 2023

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On the origins of the conflict between Rosalind Franklin and Maurice Wilkins.
Stephen Neidle

Nat Rev Chem· November 2023

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Synergistic binding of actinomycin D and echinomycin to DNA mismatch sites and their combined anti-tumour effects.
Roshan Satange, Chih-Chun Chang, Long-Yuan Li, Sheng-Hao Lin, Stephen Neidle

Nucleic Acids Res· May 2023

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The Potent G-Quadruplex-Binding Compound QN-302 Downregulates S100P Gene Expression in Cells and in an In Vivo Model of Pancreatic Cancer.
Ahmed A Ahmed, William Greenhalf, Daniel H Palmer, Nicole Williams, Jenny Worthington, Stephen Neidle

Molecules· March 2023

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Machine learning shows torsion angle preferences in left-handed and right-handed quadruplex DNAs.
Kevin Li, Liliya A Yatsunyk, Stephen Neidle

Biophys J· December 2022

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Staggered intercalation of DNA duplexes with base-pair modulation by two distinct drug molecules induces asymmetric backbone twisting and structure polymorphism.
Roshan Satange, Shih-Hao Kao, Ching-Ming Chien, Shan-Ho Chou, Chi-Chien Lin, Stephen Neidle

Nucleic Acids Res· August 2022

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Structured Waters Mediate Small Molecule Binding to G-Quadruplex Nucleic Acids.
Stephen Neidle

Pharmaceuticals (Basel)· December 2021

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Targeting the ALS/FTD-associated A-DNA kink with anthracene-based metal complex causes DNA backbone straightening and groove contraction.
Cyong-Ru Jhan, Roshan Satange, Shun-Ching Wang, Jing-Yi Zeng, Yih-Chern Horng, Stephen Neidle

Nucleic Acids Res· September 2021

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Beyond the double helix: DNA structural diversity and the PDB.
Stephen Neidle

J Biol Chem· July 2021

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Water spines and networks in G-quadruplex structures.
Kevin Li, Liliya Yatsunyk, Stephen Neidle

Nucleic Acids Res· January 2021

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Comment on "Dark Nudges and Sludge in Big Alcohol: Behavioral Economics, Cognitive Biases, and Alcohol Industry Corporate Social Responsibility".
Fiona Sim, Jonathan Chick, Sarah Jarvis, Helene Leslie, Iona Lidington, Stephen Neidle

Milbank Q· December 2020

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A G-Quadruplex-Binding Small Molecule and the HDAC Inhibitor SAHA (Vorinostat) Act Synergistically in Gemcitabine-Sensitive and Resistant Pancreatic Cancer Cells.
Ahmed Abdullah Ahmed, Stephen Neidle

Molecules· November 2020

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Asymmetrically Substituted Quadruplex-Binding Naphthalene Diimide Showing Potent Activity in Pancreatic Cancer Models.
Ahmed A Ahmed, Richard Angell, Sally Oxenford, Jenny Worthington, Nicole Williams, Stephen Neidle

ACS Med Chem Lett· August 2020

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A G-quadruplex-binding compound shows potent activity in human gemcitabine-resistant pancreatic cancer cells.
Ahmed Abdullah Ahmed, Chiara Marchetti, Stephan A Ohnmacht, Stephen Neidle

Sci Rep· July 2020

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Substituted Naphthalenediimide Compounds Bind Selectively to Two Human Quadruplex Structures with Parallel Topology.
Tam Vo, Sally Oxenford, Richard Angell, Chiara Marchetti, Stephan A Ohnmacht, Stephen Neidle

ACS Med Chem Lett· May 2020

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A Rebuttal to Lim et al.'s (2019) Examination of Drinkaware's Presentation of Pregnancy, Fertility, Breastfeeding, and Alcohol Consumption Information.
Fiona Sim, Jonathan Chick, Stephen Neidle, Graham R Ogden, Sarah Jarvis

J Stud Alcohol Drugs· May 2020

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