Publications by authors named "Stephen R Brych"

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A High Threshold of Biotherapeutic Aggregate Numbers is Needed to Induce an Immunogenic Response In Vitro, In Vivo, and in the Clinic.
Joseph R Cohen, Stephen R Brych, Siddharth Prabhu, Vivian Bi, Ahmed Elbaradei

Pharm Res· April 2024

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The identification of free cysteine residues within antibodies and a potential role for free cysteine residues in covalent aggregation because of agitation stress.
Joon H Huh, April J White, Stephen R Brych, Heather Franey, Masazumi Matsumura

J Pharm Sci· June 2013

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Increased aggregation propensity of IgG2 subclass over IgG1: role of conformational changes and covalent character in isolated aggregates.
Heather Franey, Stephen R Brych, Carl G Kolvenbach, Rahul S Rajan

Protein Sci· September 2010

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Characterization of antibody aggregation: role of buried, unpaired cysteines in particle formation.
Stephen R Brych, Yatin R Gokarn, Heather Hultgen, Riki J Stevenson, Rahul Rajan

J Pharm Sci· February 2010

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Effect of ions on agitation- and temperature-induced aggregation reactions of antibodies.
R Matthew Fesinmeyer, Sabine Hogan, Atul Saluja, Stephen R Brych, Eva Kras

Pharm Res· April 2009

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Contributions of a disulfide bond to the structure, stability, and dimerization of human IgG1 antibody CH3 domain.
Arnold McAuley, Jaby Jacob, Carl G Kolvenbach, Kimberly Westland, Hyo Jin Lee, Stephen R Brych

Protein Sci· January 2008

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Sequence swapping does not result in conformation swapping for the beta4/beta5 and beta8/beta9 beta-hairpin turns in human acidic fibroblast growth factor.
Jaewon Kim, Jihun Lee, Stephen R Brych, Timothy M Logan, Michael Blaber

Protein Sci· February 2005

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Symmetric primary and tertiary structure mutations within a symmetric superfold: a solution, not a constraint, to achieve a foldable polypeptide.
Stephen R Brych, Vikash K Dubey, Ewa Bienkiewicz, Jihun Lee, Timothy M Logan

J Mol Biol· November 2004

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Accommodation of a highly symmetric core within a symmetric protein superfold.
Stephen R Brych, Jaewon Kim, Timothy M Logan, Michael Blaber

Protein Sci· December 2003

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Identification of a key structural element for protein folding within beta-hairpin turns.
Jaewon Kim, Stephen R Brych, Jihun Lee, Timothy M Logan, Michael Blaber

J Mol Biol· May 2003

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