Publications by authors named "Stephen R Sprang"

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A galactose-based auto-expression system improves T7-inducible protein production in Escherichia coli.
James Bosco, Emily Gagliano, Kassandra L Boshae, John P Statz, Timothy B Wheeler, Stephen R Sprang

Sci Rep· March 2025

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Application of sulfur SAD to small crystals with a large asymmetric unit and anomalous substructure.
Tung Chung Mou, Baisen Zeng, Tzanko I Doukov, Stephen R Sprang

Acta Crystallogr D Struct Biol· August 2022

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The structure of the cysteine-rich region from human histone-lysine N-methyltransferase EHMT2 (G9a).
Keshia M Kerchner, Tung-Chung Mou, Yizhi Sun, Domniţa-Valeria Rusnac, Stephen R Sprang

J Struct Biol X· June 2021

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Structure of the G protein chaperone and guanine nucleotide exchange factor Ric-8A bound to Gαi1.
Levi J McClelland, Kaiming Zhang, Tung-Chung Mou, Jake Johnston, Cindee Yates-Hansen, Stephen R Sprang

Nat Commun· February 2020

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Structure, Function, and Dynamics of the Gα Binding Domain of Ric-8A.
Baisen Zeng, Tung-Chung Mou, Tzanko I Doukov, Andrea Steiner, Wenxi Yu, Stephen R Sprang

Structure· July 2019

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Crystal structure of the major quadruplex formed in the promoter region of the human c-MYC oncogene.
Sascha Stump, Tung-Chung Mou, Stephen R Sprang, Nicholas R Natale, Howard D Beall

PLoS One· April 2019

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Atypical activation of the G protein Gα by the oncogenic mutation Q209P.
Marcin Maziarz, Anthony Leyme, Arthur Marivin, Alex Luebbers, Prachi P Patel, Stephen R Sprang

J Biol Chem· December 2018

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Cytochrome c Can Form a Well-Defined Binding Pocket for Hydrocarbons.
Levi J McClelland, Harmen B B Steele, Frank G Whitby, Tung-Chung Mou, David Holley, Stephen R Sprang

J Am Chem Soc· December 2016

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Ric-8A, a G protein chaperone with nucleotide exchange activity induces long-range secondary structure changes in Gα.
Ravi Kant, Baisen Zeng, Celestine J Thomas, Brian Bothner, Stephen R Sprang

Elife· December 2016

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Structural Basis for Negative Allosteric Modulation of GluN2A-Containing NMDA Receptors.
Feng Yi, Tung-Chung Mou, Katherine N Dorsett, Robert A Volkmann, Frank S Menniti, Stephen R Sprang

Neuron· September 2016

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Invited review: Activation of G proteins by GTP and the mechanism of Gα-catalyzed GTP hydrolysis.
Stephen R Sprang

Biopolymers· August 2016

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Nanosecond Dynamics of Gαi1 Bound to Nucleotides or Ric-8A, a Gα Chaperone with GEF Activity.
Labe A Black, Celestine J Thomas, Gwendolyn N Nix, Michelle C Terwilliger, Stephen R Sprang

Biophys J· August 2016

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Catalytic Mechanism of Mammalian Adenylyl Cyclase: A Computational Investigation.
David K Hahn, Jose R Tusell, Stephen R Sprang, Xi Chu

Biochemistry· October 2015

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The guanine nucleotide exchange factor Ric-8A induces domain separation and Ras domain plasticity in Gαi1.
Ned Van Eps, Celestine J Thomas, Wayne L Hubbell, Stephen R Sprang

Proc Natl Acad Sci U S A· February 2015

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Structure of a mitochondrial cytochrome c conformer competent for peroxidase activity.
Levi J McClelland, Tung-Chung Mou, Margaret E Jeakins-Cooley, Stephen R Sprang, Bruce E Bowler

Proc Natl Acad Sci U S A· May 2014

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An acid test for g proteins.
Stephen R Sprang

Mol Cell· August 2013

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Biochemical reconstitution of hemorrhagic-fever arenavirus envelope glycoprotein-mediated membrane fusion.
Celestine J Thomas, Sundaresh Shankar, Hedi E Casquilho-Gray, Joanne York, Stephen R Sprang

PLoS One· May 2013

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Molecular chaperoning function of Ric-8 is to fold nascent heterotrimeric G protein α subunits.
Puiyee Chan, Celestine J Thomas, Stephen R Sprang, Gregory G Tall

Proc Natl Acad Sci U S A· March 2013

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Activation of p115-RhoGEF requires direct association of Gα13 and the Dbl homology domain.
Zhe Chen, Liang Guo, Jana Hadas, Stephen Gutowski, Stephen R Sprang

J Biol Chem· July 2012

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Cell signaling. Structural origins of receptor bias.
Stephen R Sprang, Jackson Chief Elk

Science· March 2012

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Inhibitors of membranous adenylyl cyclases.
Roland Seifert, Gerald H Lushington, Tung-Chung Mou, Andreas Gille, Stephen R Sprang

Trends Pharmacol Sci· February 2012

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The nucleotide exchange factor Ric-8A is a chaperone for the conformationally dynamic nucleotide-free state of Gαi1.
Celestine J Thomas, Klára Briknarová, Jonathan K Hilmer, Navid Movahed, Brian Bothner, Stephen R Sprang

PLoS One· December 2011

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Structure-activity relationships for the interactions of 2'- and 3'-(O)-(N-methyl)anthraniloyl-substituted purine and pyrimidine nucleotides with mammalian adenylyl cyclases.
Cibele Pinto, Gerald H Lushington, Mark Richter, Andreas Gille, Jens Geduhn, Stephen R Sprang

Biochem Pharmacol· August 2011

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Structural basis for the high-affinity inhibition of mammalian membranous adenylyl cyclase by 2',3'-o-(N-methylanthraniloyl)-inosine 5'-triphosphate.
Melanie Hübner, Anshuman Dixit, Tung-Chung Mou, Gerald H Lushington, Cibele Pinto, Stephen R Sprang

Mol Pharmacol· July 2011

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Cell signalling: Binding the receptor at both ends.
Stephen R Sprang

Nature· January 2011

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