Publications by authors named "Stephen Sazinsky"

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Preclinical Efficacy of VTX-0811: A Humanized First-in-Class PSGL-1 mAb Targeting TAMs to Suppress Tumor Growth.
Tatiana Novobrantseva, Denise Manfra, Jessica Ritter, Maja Razlog, Brian O'Nuallain, Stephen Sazinsky

Cancers (Basel)· August 2024

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Antibodies Targeting Human or Mouse VSIG4 Repolarize Tumor-Associated Macrophages Providing the Potential of Potent and Specific Clinical Anti-Tumor Response Induced across Multiple Cancer Types.
Stephen Sazinsky, Mohammad Zafari, Boris Klebanov, Jessica Ritter, Phuong A Nguyen

Int J Mol Sci· June 2024

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Streamlined Multi-Attribute Assessment of an Array of Clinical-Stage Antibodies: Relationship Between Degradation and Stability.
Belinda Pastrana, Elizabeth Culyba, Sherly Nieves, Stephen L Sazinsky, Eduardo I Canto

Appl Spectrosc· February 2024

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ICOS agonism by JTX-2011 (vopratelimab) requires initial T cell priming and Fc cross-linking for optimal T cell activation and anti-tumor immunity in preclinical models.
Amanda Hanson, Kutlu Elpek, Ellen Duong, Lindsey Shallberg, Martin Fan, Stephen Sazinsky

PLoS One· November 2020

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Engineering Aglycosylated IgG Variants with Wild-Type or Improved Binding Affinity to Human Fc Gamma RIIA and Fc Gamma RIIIAs.
Tiffany F Chen, Stephen L Sazinsky, Damian Houde, David J DiLillo, Julie Bird

J Mol Biol· August 2017

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Comprehensive experimental and computational analysis of binding energy hot spots at the NF-κB essential modulator/IKKβ protein-protein interface.
Mary S Golden, Shaun M Cote, Marianna Sayeg, Brandon S Zerbe, Elizabeth A Villar, Stephen L Sazinsky

J Am Chem Soc· April 2013

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Rapid evolution of functional complexity in a domain family.
Andreas Ernst, Stephen L Sazinsky, Shirley Hui, Bridget Currell, Moyez Dharsee

Sci Signal· September 2009

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Directed evolution of a secretory leader for the improved expression of heterologous proteins and full-length antibodies in Saccharomyces cerevisiae.
J Andy Rakestraw, Stephen L Sazinsky, Andrea Piatesi, Eugene Antipov, K Dane Wittrup

Biotechnol Bioeng· August 2009

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Aglycosylated immunoglobulin G1 variants productively engage activating Fc receptors.
Stephen L Sazinsky, René G Ott, Nathaniel W Silver, Bruce Tidor, Jeffrey V Ravetch

Proc Natl Acad Sci U S A· December 2008

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A specificity map for the PDZ domain family.
Raffi Tonikian, Yingnan Zhang, Stephen L Sazinsky, Bridget Currell, Jung-Hua Yeh

PLoS Biol· September 2008

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Structural and functional analysis of the PDZ domains of human HtrA1 and HtrA3.
Steven T Runyon, Yingnan Zhang, Brent A Appleton, Stephen L Sazinsky, Ping Wu

Protein Sci· November 2007

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Isolating and engineering human antibodies using yeast surface display.
Ginger Chao, Wai L Lau, Benjamin J Hackel, Stephen L Sazinsky, Shaun M Lippow

Nat Protoc· September 2007

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Stably folded de novo proteins from a designed combinatorial library.
Yinan Wei, Tun Liu, Stephen L Sazinsky, David A Moffet, István Pelczer

Protein Sci· January 2003

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