Publications by authors named "Stephen Tirrell"

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Ubiquitin-activating enzyme inhibition induces an unfolded protein response and overcomes drug resistance in myeloma.
Junling Zhuang, Fazal Shirazi, Ram Kumar Singh, Isere Kuiatse, Hua Wang, Stephen Tirrell

Blood· April 2019

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A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment.
Marc L Hyer, Michael A Milhollen, Jeff Ciavarri, Paul Fleming, Tary Traore, Stephen Tirrell

Nat Med· February 2018

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KRAS Genotype Correlates with Proteasome Inhibitor Ixazomib Activity in Preclinical In Vivo Models of Colon and Non-Small Cell Lung Cancer: Potential Role of Tumor Metabolism.
Nibedita Chattopadhyay, Allison J Berger, Erik Koenig, Bret Bannerman, James Garnsey, Stephen Tirrell

PLoS One· August 2016

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The beagle dog MicroRNA tissue atlas: identifying translatable biomarkers of organ toxicity.
Erik M Koenig, Craig Fisher, Hugues Bernard, Francis S Wolenski, Joseph Gerrein, Stephen Tirrell

BMC Genomics· August 2016

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A Sensitive IHC Method for Monitoring Autophagy-Specific Markers in Human Tumor Xenografts.
Helen He, Yu Yang, Zhongmin Xiang, Lunyin Yu, Jouhara Chouitar, Stephen Tirrell

J Biomark· June 2016

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Phase I Study of the Novel Investigational NEDD8-Activating Enzyme Inhibitor Pevonedistat (MLN4924) in Patients with Relapsed/Refractory Multiple Myeloma or Lymphoma.
Jatin J Shah, Andrzej J Jakubowiak, Owen A O'Connor, Robert Z Orlowski, R Donald Harvey, Stephen Tirrell

Clin Cancer Res· January 2016

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Phase 1 study of ixazomib, an investigational proteasome inhibitor, in advanced non-hematologic malignancies.
David C Smith, Thea Kalebic, Jeffrey R Infante, Lillian L Siu, Daniel Sullivan, Stephen Tirrell

Invest New Drugs· June 2015

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Phase I assessment of new mechanism-based pharmacodynamic biomarkers for MLN8054, a small-molecule inhibitor of Aurora A kinase.
Arijit Chakravarty, Vaishali Shinde, Josep Tabernero, Andres Cervantes, Roger B Cohen, Stephen Tirrell

Cancer Res· February 2011

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Transcriptional responses to estrogen and progesterone in mammary gland identify networks regulating p53 activity.
Shaolei Lu, Klaus A Becker, Mary J Hagen, Haoheng Yan, Amy L Roberts, Stephen M Tirrell

Endocrinology· October 2008

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Reproducibility of gene expression signature-based predictions in replicate experiments.
Keith Anderson, Kenneth R Hess, Mini Kapoor, Stephen Tirrell, Jean Courtemanche

Clin Cancer Res· March 2006

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Comparison of the predictive accuracy of DNA array-based multigene classifiers across cDNA arrays and Affymetrix GeneChips.
James Stec, Jing Wang, Kevin Coombes, Mark Ayers, Sebastian Hoersch, Stephen Tirrell

J Mol Diagn· August 2005

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