Publications by authors named "Stephen Willingham"

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Anti-CD73 antibody activates human B cells, enhances humoral responses and induces redistribution of B cells in patients with cancer.
Richard A Miller, Jason John Luke, Shenshen Hu, Suresh Mahabhashyam, William B Jones, Stephen B Willingham

J Immunother Cancer· December 2022

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Therapeutic blockade of CXCR2 rapidly clears inflammation in arthritis and atopic dermatitis models: demonstration with surrogate and humanized antibodies.
Md Jahangir Alam, Liang Xie, Caroline Ang, Farnaz Fahimi, Stephen B Willingham

MAbs· October 2021

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Combining CD47 blockade with trastuzumab eliminates HER2-positive breast cancer cells and overcomes trastuzumab tolerance.
Rosalynd Upton, Allison Banuelos, Dongdong Feng, Tanuka Biswas, Kevin Kao, Stephen Willingham

Proc Natl Acad Sci U S A· July 2021

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Targeting the A2AR in cancer; early lessons from the clinic.
Stephen B Willingham, Andrew N Hotson, Richard A Miller

Curr Opin Pharmacol· August 2020

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Adenosine 2A Receptor Blockade as an Immunotherapy for Treatment-Refractory Renal Cell Cancer.
Lawrence Fong, Andrew Hotson, John D Powderly, Mario Sznol, Rebecca S Heist, Stephen B Willingham

Cancer Discov· January 2020

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Dysregulated integrin αVβ3 and CD47 signaling promotes joint inflammation, cartilage breakdown, and progression of osteoarthritis.
Qian Wang, Kazuhiro Onuma, Changhao Liu, Heidi Wong, Michelle S Bloom, Stephen B Willingham

JCI Insight· September 2019

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A2AR Antagonism with CPI-444 Induces Antitumor Responses and Augments Efficacy to Anti-PD-(L)1 and Anti-CTLA-4 in Preclinical Models.
Stephen B Willingham, Po Y Ho, Andrew Hotson, Craig Hill, Emily C Piccione

Cancer Immunol Res· October 2018

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A CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancer.
Paola A Betancur, Brian J Abraham, Ying Y Yiu, Stephen B Willingham, Farnaz Khameneh

Nat Commun· April 2017

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Disrupting the CD47-SIRPα anti-phagocytic axis by a humanized anti-CD47 antibody is an efficacious treatment for malignant pediatric brain tumors.
Sharareh Gholamin, Siddhartha S Mitra, Abdullah H Feroze, Jie Liu, Suzana A Kahn, Stephen Willingham

Sci Transl Med· March 2017

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Pre-Clinical Development of a Humanized Anti-CD47 Antibody with Anti-Cancer Therapeutic Potential.
Jie Liu, Lijuan Wang, Feifei Zhao, Serena Tseng, Cyndhavi Narayanan, Stephen Willingham

PLoS One· May 2016

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Identification of tumorigenic cells and therapeutic targets in pancreatic neuroendocrine tumors.
Geoffrey Wayne Krampitz, Benson M George, Stephen B Willingham, Jens-Peter Volkmer, Kipp Weiskopf

Proc Natl Acad Sci U S A· April 2016

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Learning from host-defense peptides: cationic, amphipathic peptoids with potent anticancer activity.
Wei Huang, Jiwon Seo, Stephen B Willingham, Ann M Czyzewski, Mark L Gonzalgo

PLoS One· October 2014

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Isolation and mutational analysis of circulating tumor cells from lung cancer patients with magnetic sifters and biochips.
Christopher M Earhart, Casey E Hughes, Richard S Gaster, Chin Chun Ooi, Robert J Wilson, Stephen B Willingham

Lab Chip· January 2014

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Anti-CD47 antibody-mediated phagocytosis of cancer by macrophages primes an effective antitumor T-cell response.
Diane Tseng, Jens-Peter Volkmer, Stephen B Willingham, Humberto Contreras-Trujillo, John W Fathman

Proc Natl Acad Sci U S A· July 2013

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Use of a KIT-specific monoclonal antibody to bypass imatinib resistance in gastrointestinal stromal tumors.
Badreddin Edris, Stephen Willingham, Kipp Weiskopf, Anne K Volkmer, Jens-Peter Volkmer

Oncoimmunology· June 2013

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Anti-KIT monoclonal antibody inhibits imatinib-resistant gastrointestinal stromal tumor growth.
Badreddin Edris, Stephen B Willingham, Kipp Weiskopf, Anne K Volkmer, Jens-Peter Volkmer

Proc Natl Acad Sci U S A· February 2013

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The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors.
Stephen B Willingham, Jens-Peter Volkmer, Andrew J Gentles, Debashis Sahoo, Piero Dalerba

Proc Natl Acad Sci U S A· April 2012

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Antibody therapy targeting the CD47 protein is effective in a model of aggressive metastatic leiomyosarcoma.
Badreddin Edris, Kipp Weiskopf, Anne K Volkmer, Jens-Peter Volkmer, Stephen B Willingham

Proc Natl Acad Sci U S A· April 2012

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Three differentiation states risk-stratify bladder cancer into distinct subtypes.
Jens-Peter Volkmer, Debashis Sahoo, Robert K Chin, Philip Levy Ho, Chad Tang, Stephen B Willingham

Proc Natl Acad Sci U S A· February 2012

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Cutting edge: NLRC5-dependent activation of the inflammasome.
Beckley K Davis, Reid A Roberts, Max T Huang, Stephen B Willingham, Brian J Conti

J Immunol· February 2011

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Calreticulin is the dominant pro-phagocytic signal on multiple human cancers and is counterbalanced by CD47.
Mark P Chao, Siddhartha Jaiswal, Rachel Weissman-Tsukamoto, Ash A Alizadeh, Andrew J Gentles, Stephen B Willingham

Sci Transl Med· December 2010

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NLRP3 (NALP3, Cryopyrin) facilitates in vivo caspase-1 activation, necrosis, and HMGB1 release via inflammasome-dependent and -independent pathways.
Stephen B Willingham, Irving C Allen, Daniel T Bergstralh, Willie June Brickey, Max Tze-Han Huang

J Immunol· August 2009

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Neisseria gonorrhoeae activates the proteinase cathepsin B to mediate the signaling activities of the NLRP3 and ASC-containing inflammasome.
Joseph A Duncan, Xi Gao, Max Tze-Han Huang, Brian P O'Connor, Christopher E Thomas, Stephen B Willingham

J Immunol· May 2009

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Critical role of apoptotic speck protein containing a caspase recruitment domain (ASC) and NLRP3 in causing necrosis and ASC speck formation induced by Porphyromonas gingivalis in human cells.
Max Tze-Han Huang, Debra J Taxman, Elizabeth A Holley-Guthrie, Chris B Moore, Stephen B Willingham

J Immunol· February 2009

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NLRs and the dangers of pollution and aging.
Stephen B Willingham, Jenny P-Y Ting

Nat Immunol· August 2008

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