Publications by authors named "Steve Watson"

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Spleen Tyrosine Kinase Inhibition Mitigates Hemin-Induced Thromboinflammation in an Organ-Specific Manner in Sickle Cell Mice.
Juma El-Awaisi, Gina Perrella, Nicolas Mayor, Veronika Tinkova, Simon J Cleary, Steve P Watson

Arterioscler Thromb Vasc Biol· October 2025

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A minimum valency of 4 is required for robust activation of platelets in flow cytometry by multivalent nanobodies to Glycoprotein VI, C-type lectin-like receptor 2 and Platelet Endothelial Aggregation Receptor 1.
Rachel E Lamerton, Eleyna M Martin, Jacqueline Perry, Adam F Cunningham, Steve P Watson

Res Pract Thromb Haemost· October 2025

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A computational framework for the investigation of phosphoinositide regulation.
Hilaire Yam Fung Cheung, Chukiat Tantiwong, Dipali Kale, Jonathan M Gibbins, Steve P Watson

PLoS Comput Biol· September 2025

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Discrete and conserved inflammatory signatures drive thrombosis in different organs after Salmonella infection.
Marisol Perez-Toledo, Nonantzin Beristain-Covarrubias, Jamie Pillaye, Ruby R Persaud, Edith Marcial-Juarez, Steve P Watson

Nat Commun· March 2025

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Illustrated capsules from the Advanced Course in Platelet Research.
Christian Andrea Di Buduo, Vittorio Abbonante, Alessandro Malara, Alessandra Balduini, Amie K Waller, Steve P Watson

Res Pract Thromb Haemost· February 2025

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Platelet aggregation responses to Typhimurium are determined by host anti- antibody levels.
Rachel E Lamerton, Samantha J Montague, Marisol Perez-Toledo, Steve P Watson, Adam F Cunningham

Platelets· December 2024

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Selective Btk inhibition by PRN1008/PRN473 blocks human CLEC-2, and PRN473 reduces venous thrombosis formation in mice.
Christopher W Smith, Joana Campos, Helena C Brown, Natalie J Jooss, Vanesa-Sindi Ivanova, Steve P Watson

Blood Adv· November 2024

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Affimer reagents as tool molecules to modulate platelet GPVI-ligand interactions and specifically bind GPVI dimer.
Rui-Gang Xu, Christian Tiede, Antonio N Calabrese, Lih T Cheah, Thomas L Adams, Steve P Watson

Blood Adv· August 2024

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Corrigendum to 'Trivalent nanobody-based ligands mediate powerful activation of GPVI, CLEC-2 and PEAR1 in human platelets whereas FcγRIIA requires a tetravalent ligand': Journal of Thrombosis and Haemostasis, Volume 22, Issue 1, (January 2024) Pages 271-285.
Eleyna M Martin, Joanne C Clark, Samantha J Montague, Luis A Morán, Ying Di, Steve P Watson

J Thromb Haemost· August 2024

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Hydroxychloroquine inhibits hemolysis-induced arterial thrombosis ex vivo and improves lung perfusion in hemin-treated mice.
Joshua H Bourne, Gina Perrella, Juma El-Awaisi, Lauren V Terry, Veronika Tinkova, Steve P Watson

J Thromb Haemost· July 2024

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Identification of cross reactive T cell responses in adenovirus based COVID 19 vaccines.
Joshua Gardner, Simon Timothy Abrams, Cheng-Hock Toh, Alan L Parker, Charlotte Lovatt, Steve P Watson

NPJ Vaccines· June 2024

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Purification and characterisation of the platelet-activating GPVI/FcRγ complex in SMALPs.
Xueqing Wang, Alexandre Slater, Sarah C Lee, Neale Harrison, Naomi L Pollock, Steve P Watson

Arch Biochem Biophys· April 2024

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Trivalent nanobody-based ligands mediate powerful activation of GPVI, CLEC-2, and PEAR1 in human platelets whereas FcγRIIA requires a tetravalent ligand.
Eleyna M Martin, Joanne C Clark, Samantha J Montague, Luis A Morán, Ying Di, Steve P Watson

J Thromb Haemost· January 2024

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PF4 activates the c-Mpl-Jak2 pathway in platelets.
Richard J Buka, Samantha J Montague, Luis A Moran, Eleyna M Martin, Alexandre Slater, Steve P Watson

Blood· January 2024

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Amplified inhibition of atherosclerotic plaque-induced platelet activation by glenzocimab with dual antiplatelet therapy.
Fawaz O Alenazy, Maan H Harbi, Dean P Kavanagh, Joshua Price, Paul Brady, Steve P Watson

J Thromb Haemost· November 2023

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Validation of agent-based models of surface receptor oligomerisation.
Joanne C Clark, Steve P Watson, Dylan M Owen

Trends Pharmacol Sci· October 2023

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Antagonistic Roles of Human Platelet Integrin αIIbβ3 and Chemokines in Regulating Neutrophil Activation and Fate on Arterial Thrombi Under Flow.
Claudia Schönichen, Samantha J Montague, Sanne L N Brouns, James J Burston, Judith M E M Cosemans, Steve P Watson

Arterioscler Thromb Vasc Biol· September 2023

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Blood Coagulation and Beyond: Position Paper from the Fourth Maastricht Consensus Conference on Thrombosis.
Asim Cengiz Akbulut, Ryanne A Arisz, Constance C F M J Baaten, Gaukhar Baidildinova, Aarazo Barakzie, Steve P Watson

Thromb Haemost· August 2023

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Platelet glycoprotein VI cluster size is related to thrombus formation and phosphatidylserine exposure in collagen-adherent platelets under arterial shear.
Natalie J Jooss, Christopher W Smith, Jeremy A Pike, Richard W Farndale, Yvonne M C Henskens, Steve P Watson

J Thromb Haemost· August 2023

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Pharmacological Inhibition of Glycoprotein VI- and Integrin α2β1-Induced Thrombus Formation Modulated by the Collagen Type.
Natalie J Jooss, Yvonne M C Henskens, Steve P Watson, Richard W Farndale, Meinrad P Gawaz

Thromb Haemost· June 2023

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Divalent nanobodies to platelet CLEC-2 can serve as agonists or antagonists.
Joanne C Clark, Eleyna M Martin, Luis A Morán, Ying Di, Xueqing Wang, Steve P Watson

Commun Biol· April 2023

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Fibrin-glycoprotein VI interaction increases platelet procoagulant activity and impacts clot structure.
Julia S Gauer, Cédric Duval, Rui-Gang Xu, Fraser L Macrae, Helen R McPherson, Steve P Watson

J Thromb Haemost· March 2023

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Characterizing the binding of glycoprotein VI with nanobody 35 reveals a novel monomeric structure of glycoprotein VI where the conformation of D1+D2 is independent of dimerization.
Foteini-Nafsika Damaskinaki, Natalie J Jooss, Eleyna M Martin, Joanne C Clark, Mark R Thomas, Steve P Watson

J Thromb Haemost· February 2023

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Heparin and heparin proteoglycan-mimetics activate platelets via PEAR1 and PI3Kβ.
Caroline Kardeby, Alice Evans, Joana Campos, Afraa Moosa Al-Wahaibi, Christopher W Smith, Steve P Watson

J Thromb Haemost· January 2023

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