Publications by authors named "Steven A Berkowitz"

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Particle size distribution resolution limit of AAV high-speed sedimentation velocity protocol relative to low-speed sedimentation velocity protocol, mass photometry, and charge-detection mass spectrometry.
Bashkim Kokona, Austin Vogt, Neal Whitaker, Aubree O'Neill, Kevin D Ausman, Steven A Berkowitz

J Pharm Sci· August 2025

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Using absorbance detection for hs-SV-AUC characterization of adeno-associated virus.
Nicholas R Larson, George M Bou-Assaf, Thomas M Laue, Steven A Berkowitz

Anal Biochem· November 2024

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Rapid high-resolution size distribution protocol for adeno-associated virus using high speed SV-AUC.
Steven A Berkowitz, Nicholas Larson, George Bou-Assaf, Thomas Laue

Anal Biochem· June 2024

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Boundary convection during sedimentation velocity in the Optima analytical ultracentrifuge.
Steven A Berkowitz, Thomas Laue

Anal Biochem· October 2021

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Deciphering the Biophysical Effects of Oxidizing Sulfur-Containing Amino Acids in Interferon-beta-1a using MS and HDX-MS.
Damian J Houde, George M Bou-Assaf, Steven A Berkowitz

J Am Soc Mass Spectrom· May 2017

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Investigating monoclonal antibody aggregation using a combination of H/DX-MS and other biophysical measurements.
Roxana E Iacob, George M Bou-Assaf, Lee Makowski, John R Engen, Steven A Berkowitz

J Pharm Sci· December 2013

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An interaction between DNA polymerase and helicase is essential for the high processivity of the bacteriophage T7 replisome.
Arkadiusz W Kulczyk, Barak Akabayov, Seung-Joo Lee, Mihnea Bostina, Steven A Berkowitz

J Biol Chem· November 2012

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Analytical tools for characterizing biopharmaceuticals and the implications for biosimilars.
Steven A Berkowitz, John R Engen, Jeffrey R Mazzeo, Graham B Jones

Nat Rev Drug Discov· June 2012

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Conformational comparability of factor IX-Fc fusion protein, factor IX, and purified Fc fragment in the absence and presence of calcium.
Damian Houde, Steven A Berkowitz

J Pharm Sci· May 2012

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Calcium binding to a factor ix Fc fusion protein and effects on higher-order structure.
Hao Li, Shufeng Bai, Julie Y Wei, Steven A Berkowitz, Mark L Brader

J Pharm Sci· November 2011

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The utility of hydrogen/deuterium exchange mass spectrometry in biopharmaceutical comparability studies.
Damian Houde, Steven A Berkowitz, John R Engen

J Pharm Sci· June 2011

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Post-translational modifications differentially affect IgG1 conformation and receptor binding.
Damian Houde, Yucai Peng, Steven A Berkowitz, John R Engen

Mol Cell Proteomics· August 2010

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Improving the solubility of anti-LINGO-1 monoclonal antibody Li33 by isotype switching and targeted mutagenesis.
R Blake Pepinsky, Laura Silvian, Steven A Berkowitz, Graham Farrington, Alexey Lugovskoy

Protein Sci· May 2010

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Conformation and dynamics of biopharmaceuticals: transition of mass spectrometry-based tools from academe to industry.
Igor A Kaltashov, Cedric E Bobst, Rinat R Abzalimov, Steven A Berkowitz, Damian Houde

J Am Soc Mass Spectrom· March 2010

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Detection and characterization of altered conformations of protein pharmaceuticals using complementary mass spectrometry-based approaches.
Cedric E Bobst, Rinat R Abzalimov, Damian Houde, Marek Kloczewiak, Rohin Mhatre, Steven A Berkowitz

Anal Chem· October 2008

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Determining the concentration and the absorptivity factor at 260 nm in sodium dodecyl sulfate of the adenovirus reference material using analytical ultracentrifugation.
Steven A Berkowitz

Anal Biochem· September 2008

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Monitoring the homogeneity of adenovirus preparations (a gene therapy delivery system) using analytical ultracentrifugation.
Steven A Berkowitz, John S Philo

Anal Biochem· March 2007

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Role of analytical ultracentrifugation in assessing the aggregation of protein biopharmaceuticals.
Steven A Berkowitz

AAPS J· September 2006

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Rapid quantitative capillary zone electrophoresis method for monitoring the micro-heterogeneity of an intact recombinant glycoprotein.
Steven A Berkowitz, Huijuan Zhong, Martha Berardino, Zoran Sosic, Joseph Siemiatkoski

J Chromatogr A· June 2005

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