Publications by authors named "Steven A Jacobs"

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Folding-mediated secretion of pure bispecific antibodies.
Cholpon Tilegenova, Tun Liu, Qian Zhao, Mahati Are, Yu Zhao, Steven A Jacobs

Nat Biotechnol· October 2025

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Author Correction: Folding-mediated secretion of pure bispecific antibodies.
Cholpon Tilegenova, Tun Liu, Qian Zhao, Mahati Are, Yu Zhao, Steven A Jacobs

Nat Biotechnol· October 2025

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A novel label-free method to determine equilibrium dissociation constants of antibodies binding to cell surface proteins.
Eilyn R Lacy, Rupesh Nanjunda, Scott L Klakamp, Deborah Kwok, Jennifer F Nemeth, Steven A Jacobs

Sci Rep· January 2025

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The Scientific Consensus on When a Human's Life Begins.
Steven Andrew Jacobs

Issues Law Med· January 2023

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In Pursuit of Stability Enhancement of a Prostate Cancer Targeting Antibody Derived from a Transgenic Animal Platform.
Sathya Venkataramani, Robin Ernst, Mehabaw Getahun Derebe, Robert Wright, Jessica Kopenhaver, Steven A Jacobs

Sci Rep· June 2020

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Conformational flexibility of an anti-IL-13 DARPin†.
Alexey Teplyakov, Thomas J Malia, Galina Obmolova, Steven A Jacobs, Karyn T O'Neil

Protein Eng Des Sel· January 2017

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Engineering a targeted delivery platform using Centyrins.
Shalom D Goldberg, Rosa M F Cardoso, Tricia Lin, Tracy Spinka-Doms, Donna Klein, Steven A Jacobs

Protein Eng Des Sel· December 2016

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Constellation recovery and impairment evaluation through minimization of the blind EVM.
Steven A Jacobs, Robert A Marsland

Opt Express· September 2016

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Fusion to a highly stable consensus albumin binding domain allows for tunable pharmacokinetics.
Steven A Jacobs, Alan C Gibbs, Michelle Conk, Fang Yi, Diane Maguire

Protein Eng Des Sel· October 2015

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Induced conformational change in human IL-4 upon binding of a signal-neutralizing DARPin.
Galina Obmolova, Alexey Teplyakov, Thomas J Malia, Edward Keough, Jinquan Luo, Steven A Jacobs

Proteins· June 2015

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Selection of high-affinity Centyrin FN3 domains from a simple library diversified at a combination of strand and loop positions.
Michael D Diem, Linus Hyun, Fang Yi, Randi Hippensteel, Elise Kuhar, Steven A Jacobs

Protein Eng Des Sel· October 2014

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C-terminal β-strand swapping in a consensus-derived fibronectin Type III scaffold.
Alexey Teplyakov, Galina Obmolova, Thomas J Malia, Jinquan Luo, Steven A Jacobs

Proteins· July 2014

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N-terminal β-strand swapping in a consensus-derived alternative scaffold driven by stabilizing hydrophobic interactions.
Jinquan Luo, Alexey Teplyakov, Galina Obmolova, Thomas J Malia, Winnie Chan, Steven A Jacobs

Proteins· July 2014

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Mechanisms of self-association of a human monoclonal antibody CNTO607.
Deidra Bethea, Sheng-Jiun Wu, Jinquan Luo, Linus Hyun, Eilyn R Lacy, Steven A Jacobs

Protein Eng Des Sel· October 2012

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Design of novel FN3 domains with high stability by a consensus sequence approach.
Steven A Jacobs, Michael D Diem, Jinquan Luo, Alexey Teplyakov, Galina Obmolova

Protein Eng Des Sel· March 2012

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Structure-based engineering of a monoclonal antibody for improved solubility.
Sheng-Jiun Wu, Jinquan Luo, Karyn T O'Neil, James Kang, Eilyn R Lacy, Steven A Jacobs

Protein Eng Des Sel· August 2010

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Cross-interaction chromatography: a rapid method to identify highly soluble monoclonal antibody candidates.
Steven A Jacobs, Sheng-Jiun Wu, Yiqing Feng, Deidra Bethea, Karyn T O'Neil

Pharm Res· January 2010

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Specificity of the chromodomain Y chromosome family of chromodomains for lysine-methylated ARK(S/T) motifs.
Wolfgang Fischle, Henriette Franz, Steven A Jacobs, C David Allis, Sepideh Khorasanizadeh

J Biol Chem· July 2008

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Crystal structure of the essential N-terminal domain of telomerase reverse transcriptase.
Steven A Jacobs, Elaine R Podell, Thomas R Cech

Nat Struct Mol Biol· March 2006

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Soluble domains of telomerase reverse transcriptase identified by high-throughput screening.
Steven A Jacobs, Elaine R Podell, Deborah S Wuttke, Thomas R Cech

Protein Sci· August 2005

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Assays for the determination of structure and dynamics of the interaction of the chromodomain with histone peptides.
Steven A Jacobs, Wolfgang Fischle, Sepideh Khorasanizadeh

Methods Enzymol· July 2004

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Dental caries in school-age children residing in five Guatemalan communities.
Luis Archila, Robert D Bartizek, Robert W Gerlach, Steven A Jacobs, Aaron R Biesbrock

J Clin Dent· December 2003

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Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains.
Wolfgang Fischle, Yanming Wang, Steven A Jacobs, Youngchang Kim, C David Allis

Genes Dev· August 2003

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Analysis of mode structure in hollow dielectric waveguide fibers.
Mihai Ibanescu, Steven G Johnson, Marin Soljacić, J D Joannopoulos, Yoel Fink, Steven A Jacobs

Phys Rev E Stat Nonlin Soft Matter Phys· April 2003

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Dielectric profile variations in high-index-contrast waveguides, coupled mode theory, and perturbation expansions.
M Skorobogatiy, Steven G Johnson, Steven A Jacobs, Yoel Fink

Phys Rev E Stat Nonlin Soft Matter Phys· April 2003

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