Publications by authors named "Steven D Cappell"

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Transient APC/C inactivation by mTOR boosts glycolysis during cell cycle entry.
Debasish Paul, Derek L Bolhuis, Hualong Yan, Sudipto Das, Xia Xu, Steven D Cappell

Nature· October 2025

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Discovery of potent and selective PROTACs for the protein kinase LZK for the treatment of head and neck cancer.
Meghri Katerji, Knickole L Bergman, Eric Lindberg, Maxine R Rubin, Marwa Afifi, Steven D Cappell

J Biol Chem· May 2025

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Lineage-specific CDK activity dynamics characterize early mammalian development.
Bechara Saykali, Andy D Tran, James A Cornwell, Matthew A Caldwell, Paniz Rezvan Sangsari, Steven D Cappell

Cell Rep· April 2025

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Targeting c-MYC and gain-of-function p53 through inhibition or degradation of the kinase LZK suppresses the growth of HNSCC tumors.
Amy L Funk, Meghri Katerji, Marwa Afifi, Katherine Nyswaner, Carolyn C Woodroofe, Steven D Cappell

Sci Signal· February 2025

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Targeting GOF p53 and c-MYC through LZK Inhibition or Degradation Suppresses Head and Neck Tumor Growth.
Amy L Funk, Meghri Katerji, Marwa Afifi, Katherine Nyswaner, Carolyn C Woodroofe, Steven D Cappell

bioRxiv· November 2024

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Abrogation of the G2/M checkpoint as a chemosensitization approach for alkylating agents.
Fengchao Lang, James A Cornwell, Karambir Kaur, Omar Elmogazy, Wei Zhang, Steven D Cappell

Neuro Oncol· June 2024

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Author Correction: Loss of CDK4/6 activity in S/G2 phase leads to cell cycle reversal.
James A Cornwell, Adrijana Crncec, Marwa M Afifi, Kristina Tang, Ruhul Amin, Steven D Cappell

Nature· June 2024

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Lineage-specific CDK activity dynamics characterize early mammalian development.
Bechara Saykali, Andy D Tran, James A Cornwell, Matthew A Caldwell, Paniz Rezvan Sangsari, Steven D Cappell

bioRxiv· June 2024

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Comprehensive mapping of cell fates in microsatellite unstable cancer cells supports dual targeting of WRN and ATR.
Dali Zong, Natasha C Koussa, James A Cornwell, Ajith V Pankajam, Michael J Kruhlak, Steven D Cappell

Genes Dev· October 2023

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Irreversible cell cycle exit associated with senescence is mediated by constitutive MYC degradation.
Marwa M Afifi, Adrijana Crncec, James A Cornwell, Christophe Cataisson, Debasish Paul, Steven D Cappell

Cell Rep· September 2023

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Loss of CDK4/6 activity in S/G2 phase leads to cell cycle reversal.
James A Cornwell, Adrijana Crncec, Marwa M Afifi, Kristina Tang, Ruhul Amin, Steven D Cappell

Nature· July 2023

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Comprehensive mapping of cell fates in microsatellite unstable cancer cells support dual targe6ng of WRN and ATR.
Dali Zong, Natasha C Koussa, James A Cornwell, Ajith V Pankajam, Michael J Kruhlak, Steven D Cappell

bioRxiv· July 2023

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The adapter protein FADD provides an alternate pathway for entry into the cell cycle by regulating APC/C-Cdh1 E3 ubiquitin ligase activity.
Sahezeel Awadia, Merna Sitto, Sundaresh Ram, Wenbin Ji, Yajing Liu, Steven D Cappell

J Biol Chem· June 2023

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Apoptosis-induced nuclear expulsion in tumor cells drives S100a4-mediated metastatic outgrowth through the RAGE pathway.
Woo-Yong Park, Justin M Gray, Ronald J Holewinski, Thorkell Andresson, Jae Young So, Steven D Cappell

Nat Cancer· March 2023

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Revealing β-TrCP activity dynamics in live cells with a genetically encoded biosensor.
Debasish Paul, Stephen C Kales, James A Cornwell, Marwa M Afifi, Ganesha Rai, Steven D Cappell

Nat Commun· October 2022

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Nuclear pore protein NUP210 depletion suppresses metastasis through heterochromatin-mediated disruption of tumor cell mechanical response.
Ruhul Amin, Anjali Shukla, Jacqueline Jufen Zhu, Sohyoung Kim, Ping Wang, Steven D Cappell

Nat Commun· December 2021

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Cell cycle inertia underlies a bifurcation in cell fates after DNA damage.
Jenny F Nathans, James A Cornwell, Marwa M Afifi, Debasish Paul, Steven D Cappell

Sci Adv· January 2021

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Ribosome biogenesis is a downstream effector of the oncogenic U2AF1-S34F mutation.
Abdalla Akef, Kathy McGraw, Steven D Cappell, Daniel R Larson

PLoS Biol· November 2020

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Stress-mediated exit to quiescence restricted by increasing persistence in CDK4/6 activation.
Hee Won Yang, Steven D Cappell, Ariel Jaimovich, Chad Liu, Mingyu Chung

Elife· April 2020

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The RepID-CRL4 ubiquitin ligase complex regulates metaphase to anaphase transition via BUB3 degradation.
Sang-Min Jang, Jenny F Nathans, Haiqing Fu, Christophe E Redon, Lisa M Jenkins, Steven D Cappell

Nat Commun· January 2020

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Transient Hysteresis in CDK4/6 Activity Underlies Passage of the Restriction Point in G1.
Mingyu Chung, Chad Liu, Hee Won Yang, Marielle S Köberlin, Steven D Cappell

Mol Cell· November 2019

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EMI1 switches from being a substrate to an inhibitor of APC/C to start the cell cycle.
Steven D Cappell, Kevin G Mark, Damien Garbett, Lindsey R Pack, Michael Rape

Nature· June 2018

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Irreversible APC(Cdh1) Inactivation Underlies the Point of No Return for Cell-Cycle Entry.
Steven D Cappell, Mingyu Chung, Ariel Jaimovich, Sabrina L Spencer, Tobias Meyer

Cell· June 2016

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The proliferation-quiescence decision is controlled by a bifurcation in CDK2 activity at mitotic exit.
Sabrina L Spencer, Steven D Cappell, Feng-Chiao Tsai, K Wesley Overton, Clifford L Wang

Cell· October 2013

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Cell cycle-dependent phosphorylation and ubiquitination of a G protein alpha subunit.
Matthew P Torres, Sarah T Clement, Steven D Cappell, Henrik G Dohlman

J Biol Chem· June 2011

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