Publications by authors named "Steven Good"

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Mapping the impact of 1'-, 2'- and 4'-nucleotide modifications on the Respiratory Syncytial Virus RNA-dependent RNA polymerase.
Priscila Sutto-Ortiz, Barbara Selisko, François Ferron, Jean-Pierre Sommadossi, Adel Moussa, Steven Good

Antiviral Res· December 2025

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Bemnifosbuvir and ruzasvir in combination exhibit potent synergistic antiviral activity in vitro while maintaining a favorable nonclinical safety profile in vivo.
Steven S Good, Shouqi Luo, Kai Lin, Alex Vo, Nancy G B Agrawal

Antiviral Res· May 2025

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The activation cascade of the broad-spectrum antiviral bemnifosbuvir characterized at atomic resolution.
Aurélie Chazot, Claire Zimberger, Mikael Feracci, Adel Moussa, Steven Good

PLoS Biol· August 2024

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An exonuclease-resistant chain-terminating nucleotide analogue targeting the SARS-CoV-2 replicase complex.
Ashleigh Shannon, Aurélie Chazot, Mikael Feracci, Camille Falcou, Véronique Fattorini, Steven Good

Nucleic Acids Res· February 2024

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Bemnifosbuvir (BEM, AT-527), a novel nucleotide analogue inhibitor of the hepatitis C virus NS5B polymerase.
Xiao-Jian Zhou, Steven S Good, Keith Pietropaolo, Qi Huang, Adel Moussa

Expert Opin Investig Drugs· January 2024

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A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase.
Ashleigh Shannon, Véronique Fattorini, Bhawna Sama, Barbara Selisko, Mikael Feracci, Steven S Good

Nat Commun· February 2022

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AT-752, a double prodrug of a guanosine nucleotide analog, inhibits yellow fever virus in a hamster model.
Kai Lin, Steven S Good, Justin G Julander, Abbie E Weight, Adel Moussa

PLoS Negl Trop Dis· January 2022

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Evaluation of AT-752, a Double Prodrug of a Guanosine Nucleotide Analog with and Activity against Dengue and Other Flaviviruses.
Steven S Good, Ashleigh Shannon, Kai Lin, Adel Moussa, Justin G Julander

Antimicrob Agents Chemother· October 2021

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AT-527, a Double Prodrug of a Guanosine Nucleotide Analog, Is a Potent Inhibitor of SARS-CoV-2 and a Promising Oral Antiviral for Treatment of COVID-19.
Steven S Good, Jonna Westover, Kie Hoon Jung, Xiao-Jian Zhou, Adel Moussa

Antimicrob Agents Chemother· March 2021

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Preclinical evaluation of AT-527, a novel guanosine nucleotide prodrug with potent, pan-genotypic activity against hepatitis C virus.
Steven S Good, Adel Moussa, Xiao-Jian Zhou, Keith Pietropaolo, Jean-Pierre Sommadossi

PLoS One· April 2020

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Safety, pharmacokinetics and antiviral activity of AT-527, a novel purine nucleotide prodrug, in HCV-infected subjects with and without cirrhosis.
Elina Berliba, Maxim Bogus, Frédéric Vanhoutte, Pieter-Jan Berghmans, Steven S Good

Antimicrob Agents Chemother· September 2019

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Pharmacokinetics of IDX184, a liver-targeted oral prodrug of 2'-methylguanosine-5'-monophosphate, in the monkey and formulation optimization for human exposure.
Xin-Ru Pan-Zhou, Benjamin A Mayes, Hassan Rashidzadeh, Rahela Gasparac, Steven Smith, Steven S Good

Eur J Drug Metab Pharmacokinet· October 2016

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Overcoming stability challenges in the quantification of tissue nucleotides: determination of 2'-C-methylguanosine triphosphate concentration in mouse liver.
Hassan Rashidzadeh, Sanjeev Bhadresa, Steven Spencer Good, Marita Larsson Cohen, Kusum Sachdev Gupta

Biol Pharm Bull· November 2015

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Estimation of human drug clearance using multiexponential techniques.
Kosalaram Goteti, Patrick J Brassil, Steven S Good, C Edwin Garner

J Clin Pharmacol· October 2008

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Potent and selective inhibition of human cytomegalovirus replication by 1263W94, a benzimidazole L-riboside with a unique mode of action.
Karen K Biron, Robert J Harvey, Stanley C Chamberlain, Steven S Good, Albert A Smith

Antimicrob Agents Chemother· August 2002

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Preclinical and toxicology studies of 1263W94, a potent and selective inhibitor of human cytomegalovirus replication.
George W Koszalka, Nelson W Johnson, Steven S Good, Leslie Boyd, Stanley C Chamberlain

Antimicrob Agents Chemother· August 2002

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