Publications by authors named "Steven Gygi"

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CEBPA repression by MECOM blocks differentiation to drive aggressive leukemias.
Travis J Fleming, Mateusz Antoszewski, Sander Lambo, Michael C Gundry, Riccardo Piussi, Steven P Gygi

Blood· December 2025

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Enrichment-Free, Targeted Covalent Drug Discovery in Live Cells.
Kevin D Dong, Qing Yu, Ka Yang, Bertrand J Wong, Hong Yue, Steven P Gygi

ACS Chem Biol· December 2025

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Inhibition of oligomeric BAX by an anti-apoptotic dimer.
Catherine E Newman, Micah A Gygi, Haleh Alimohamadi, Thomas M DeAngelo, Christina M Camara, Steven P Gygi

Cell· December 2025

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A triple-action PROTAC for wild-type p53 cancer therapy.
Gregory H Bird, Utsarga Adhikary, Michael J Schmidt, Marina Godes, Bethany Tesar, Steven P Gygi

Cell Rep Med· December 2025

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Altered Molecular Regulation of TUG Is a Central Feature of Insulin-Resistant Human Adipose Tissue.
Jordan W Strober, Kasper W Ter Horst, Daeun Sung, Aldo Jongejan, Aaron L Slusher, Steven P Gygi

Diabetes· December 2025

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Multiomic analysis reveals a key BCAT1 role in mTOR activation by B cell receptor and TLR9.
Rui Guo, Yizhe Sun, Matthew Y Lim, Hardik Shah, Joao A Paulo, Steven P Gygi

J Clin Invest· November 2025

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Shifted assembly and function of mSWI/SNF family subcomplexes underlie targetable dependencies in dedifferentiated endometrial carcinomas.
Jessica D St Laurent, Grace D Xu, Alexander W Ying, Bengul Gokbayrak, Ajinkya Patil, Steven P Gygi

Nat Genet· November 2025

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Therapeutic remodeling of the ceramide backbone prevents kidney injury.
Rebekah J Nicholson, Luis Cedeño-Rosario, J Alan Maschek, Trevor Lonergan, Jonathan G Van Vranken, Steven P Gygi

Cell Metab· November 2025

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Neuronal activity triggers widespread changes in RNA stability.
Erin E Duffy, Inés L Patop, Shelly Kalaora, Elena G Assad, Shon A Koren, Steven P Gygi

bioRxiv· October 2025

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Cardiac adaptation to endurance exercise training requires suppression of GDF15 via PGC-1α.
Sumeet A Khetarpal, Haobo Li, Tevis Vitale, James Rhee, Saketh Challa, Steven P Gygi

Nat Cardiovasc Res· October 2025

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Publisher Correction: Multimodal cell maps as a foundation for structural and functional genomics.
Leah V Schaffer, Mengzhou Hu, Gege Qian, Kyung-Mee Moon, Abantika Pal, Steven P Gygi

Nature· October 2025

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Ribosome remodeling drives translation adaptation during viral infection and cellular stress.
Hsin-Yu Tsai, Luochen Liu, Rebecca H Fleming, Julian Mintseris, Derrick Ekanayake, Steven P Gygi

bioRxiv· October 2025

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Shifted assembly and function of mSWI/SNF family subcomplexes underlie targetable dependencies in dedifferentiated endometrial carcinomas.
Jessica D St Laurent, Grace D Xu, Alexander W Ying, Bengul Gokbayrak, Ajinkya Patil, Steven P Gygi

bioRxiv· October 2025

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Proteome Landscapes Decode Organelle Vulnerabilities in cortical and dopaminergic-like induced neurons Across Lysosomal Storage Disorders.
Felix Kraus, Yuchen He, Yizhi Jiang, Delong Li, Yohannes A Ambaw, Steven P Gygi

bioRxiv· October 2025

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Muscle-specific increased expression of improves the skeletal muscle phenotype in dystrophin-deficient mice.
Felipe de Souza Leite, Matthias R Lambert, Tracy Yuanfan Zhang, James R Conner, Joao A Paulo, Steven P Gygi

Proc Natl Acad Sci U S A· September 2025

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Deazaguanylation is a nucleobase-protein conjugation required for type IV CBASS immunity.
Douglas R Wassarman, Patrick Pfaff, Joao A Paulo, Steven P Gygi, Kevan M Shokat

Science· September 2025

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Next-Generation Multiplexed Targeted Proteomics Quantifies Post-Translational Modifications, Compound-Protein Interactions, and Disease Biomarkers with High Throughput.
Steven R Shuken, Geordon A Frere, Charlotte R Beard, Jesse D Canterbury, Nathan R Zuniga, Steven P Gygi

bioRxiv· September 2025

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Library-Free Multiplexed Targeted Proteomics Enables Quantitative Protein-Level Genotyping.
Steven R Shuken, Steven P Gygi

bioRxiv· September 2025

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Lysosome-dependent nutrient scavenging underlies stress adaptation during epithelial-to-mesenchymal transition.
Michal J Nagiec, Paola M Cavaliere, Friederike Dundar, Derrick M Spencer, Nikolaos Koundouros, Steven P Gygi

bioRxiv· September 2025

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A SWI/SNF-specific Ig-like domain, SWIFT, is a transcription factor binding platform.
Siddhant U Jain, Kaylyn E Williamson, Alexander W Ying, Ruidong Jerry Jiang, Aasha M Turner, Steven P Gygi

bioRxiv· August 2025

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On-target toxicity limits the efficacy of CDK11 inhibition against cancers with 1p36 deletions.
Linda Julian, Lisa Crozier, Devon Lukow, Sanat Mishra, Aditi Swamy, Steven P Gygi

bioRxiv· August 2025

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Highly specific intracellular ubiquitination of a small molecule.
Weicheng Li, Enrique M Garcia-Rivera, Dylan C Mitchell, Joel M Chick, Micah Maetani, Steven P Gygi

Nat Chem Biol· August 2025

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Episodic transport of protein aggregates achieves a positive size selectivity in aggresome formation.
Rui Fang, Luolan Bai, Bert M Verheijen, Boyan Li, Kevin Dong, Steven Gygi

Nat Commun· August 2025

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Catalytic pocket of Clr4 (Suv39h) methyltransferase serves as a substrate receptor for Cullin 4-dependent histone H3 ubiquitination.
Katarina Psenakova, Swapnil S Parhad, Joao A Paulo, Xinyue Liu, Emily F Patterson, Steven P Gygi

bioRxiv· August 2025

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Baseline expression of c-Myc defines the tissue specificity of oncogenic K-Ras.
Olesja Popow, Qing Yu, Clarance Yapp, Shannon Hull, João A Paulo, Steven P Gygi

bioRxiv· July 2025

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