Publications by authors named "Steven Hansel"

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Identifying biomarkers for treatment of uveal melanoma by T cell engager using a QSP model.
Samira Anbari, Hanwen Wang, Theinmozhi Arulraj, Masoud Nickaeen, Minu Pilvankar, Steven Hansel

NPJ Syst Biol Appl· September 2024

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Human Dose and Pharmacokinetic Predictions for Biologics at Boehringer Ingelheim: A Retrospective Analysis.
Rolf Grempler, Jennifer Ahlberg, Eva Germovsek, Priyanka Gupta, Hua Li, Steven Hansel

Adv Ther· January 2024

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Systemically Administered Anti-uPAR Antibody Plasma and Lung ELF Pharmacokinetics Characterized by Minimal Lung PBPK Model.
Sharad Sharma, Antony Leonard, Kathryn Phoenix, Hsueh Yuan Chang, Jun Wang, Steven Hansel

AAPS PharmSciTech· November 2023

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Using quantitative systems pharmacology modeling to optimize combination therapy of anti-PD-L1 checkpoint inhibitor and T cell engager.
Samira Anbari, Hanwen Wang, Yu Zhang, Jun Wang, Minu Pilvankar, Steven Hansel

Front Pharmacol· June 2023

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Trends in industrialization of biotherapeutics: a survey of product characteristics of 89 antibody-based biotherapeutics.
Kyle P Martin, Christine Grimaldi, Rolf Grempler, Steven Hansel, Sandeep Kumar

MAbs· April 2023

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Development of novel ultra-sensitive IL-11 target engagement assays to support mechanistic PK/PD modeling for an anti-IL-11 antibody therapeutic.
Maria Myzithras, Siqi Lin, Legairre Radden, Cynthia Hess Kenny, Zheng Cai, Steven Hansel

MAbs· August 2022

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Analyze impact of tumor-associated kinetics on antibody delivery in solid tumors with a physiologically based pharmacokinetics/pharmacodynamics model.
Jun Wang, Craig Giragossian, Steven Hansel

Eur J Pharm Biopharm· November 2021

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Retrospective analysis of model-based predictivity of human pharmacokinetics for anti-IL-36R monoclonal antibody MAB92 using a rat anti-mouse IL-36R monoclonal antibody and RNA expression data (FANTOM5).
Jennifer Ahlberg, Craig Giragossian, Hua Li, Maria Myzithras, Ernie Raymond, Steven Hansel

MAbs· July 2019

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Quantitative Conjugated Payload Measurement Using Enzymatic Release of Antibody-Drug Conjugate with Cleavable Linker.
Brian Rago, L Nathan Tumey, Cong Wei, Frank Barletta, Tracey Clark, Steven Hansel

Bioconjug Chem· February 2017

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Where Did the Linker-Payload Go? A Quantitative Investigation on the Destination of the Released Linker-Payload from an Antibody-Drug Conjugate with a Maleimide Linker in Plasma.
Cong Wei, Guodong Zhang, Tracey Clark, Frank Barletta, L Nathan Tumey, Steven Hansel

Anal Chem· May 2016

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Key bioanalytical measurements for antibody-drug conjugate development: PK/PD modelers' perspective.
Dhaval K Shah, Frank Barletta, Alison Betts, Steven Hansel

Bioanalysis· May 2013

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Inhibitors of HIV-1 attachment. Part 9: an assessment of oral prodrug approaches to improve the plasma exposure of a tetrazole-containing derivative.
Kap-Sun Yeung, Zhilei Qiu, Zheng Yang, Lisa Zadjura, Celia J D'Arienzo, Steven Hansel

Bioorg Med Chem Lett· January 2013

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Inhibitors of HIV-1 attachment. Part 8: the effect of C7-heteroaryl substitution on the potency, and in vitro and in vivo profiles of indole-based inhibitors.
Kap-Sun Yeung, Zhilei Qiu, Zhiwei Yin, Ashok Trehan, Haiquan Fang, Steven Hansel

Bioorg Med Chem Lett· January 2013

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Inhibitors of HIV-1 attachment. Part 7: indole-7-carboxamides as potent and orally bioavailable antiviral agents.
Kap-Sun Yeung, Zhilei Qiu, Quifen Xue, Haiquan Fang, Zheng Yang, Steven Hansel

Bioorg Med Chem Lett· January 2013

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Immune-mediated agranulocytosis caused by the cocaine adulterant levamisole: a case for reactive metabolite(s) involvement.
Angela Wolford, Thomas S McDonald, Heather Eng, Steven Hansel, Yue Chen

Drug Metab Dispos· June 2012

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LC-MS/MS method development and validation for the determination of polymyxins and vancomycin in rat plasma.
Chang Cheng, Shaorong Liu, Deqing Xiao, John Hollembaek, Lili Yao, Steven Hansel

J Chromatogr B Analyt Technol Biomed Life Sci· October 2010

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Utilization of in vitro Caco-2 permeability and liver microsomal half-life screens in discovering BMS-488043, a novel HIV-1 attachment inhibitor with improved pharmacokinetic properties.
Zheng Yang, Lisa M Zadjura, Anthony M Marino, Celia J D'Arienzo, Jacek Malinowski, Steven B Hansel

J Pharm Sci· April 2010

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Nitrogen-appended N-alkylsulfonamides as inhibitors of gamma-secretase.
Carl P Bergstrom, Charles P Sloan, Henry H Wang, Michael F Parker, David W Smith, Steven B Hansel

Bioorg Med Chem Lett· January 2008

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Carbamate-appended N-alkylsulfonamides as inhibitors of gamma-secretase.
Carl P Bergstrom, Charles P Sloan, Wai-Yu Lau, David W Smith, Ming Zheng, Steven B Hansel

Bioorg Med Chem Lett· January 2008

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N-(5-chloro-2-(hydroxymethyl)-N-alkyl-arylsulfonamides as gamma-secretase inhibitors.
Michael F Parker, Donna M Barten, Carl P Bergstrom, Joanne J Bronson, Jason A Corsa, Steven B Hansel

Bioorg Med Chem Lett· August 2007

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Novel 1H-(benzimidazol-2-yl)-1H-pyridin-2-one inhibitors of insulin-like growth factor I (IGF-1R) kinase.
Mark D Wittman, Balu Balasubramanian, Karen Stoffan, Upender Velaparthi, Pieying Liu, Steven Hansel

Bioorg Med Chem Lett· February 2007

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Preclinical pharmacokinetics of a novel HIV-1 attachment inhibitor BMS-378806 and prediction of its human pharmacokinetics.
Zheng Yang, Lisa Zadjura, Celia D'Arienzo, Anthony Marino, Kenneth Santone, Steven Hansel

Biopharm Drug Dispos· December 2005

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Discovery of a (1H-benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) inhibitor of insulin-like growth factor I receptor kinase with in vivo antitumor activity.
Mark Wittman, Joan Carboni, Ricardo Attar, Balu Balasubramanian, Praveen Balimane, Steven Hansel

J Med Chem· September 2005

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In vitro ADME phenotyping in drug discovery: current challenges and future solutions.
J Andrew Williams, Jonathan Bauman, Hongliang Cai, Kevin Conlon, Steven Hansel

Curr Opin Drug Discov Devel· January 2005

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Hydroxytriamides as potent gamma-secretase inhibitors.
C V C Prasad, Owen B Wallace, Jeffrey W Noonan, Charles P Sloan, Wai Lau, Steven B Hansel

Bioorg Med Chem Lett· April 2004

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