Publications by authors named "Steven Ledbetter"

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CXA-10, a Nitrated Fatty Acid, Is Renoprotective in Deoxycorticosterone Acetate-Salt Nephropathy.
Cynthia M Arbeeny, Hong Ling, Mandy M Smith, Stephen O'Brien, Stefan Wawersik, Steven R Ledbetter

J Pharmacol Exp Ther· June 2019

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A Phase 2, Double-Blind, Placebo-Controlled, Randomized Study of Fresolimumab in Patients With Steroid-Resistant Primary Focal Segmental Glomerulosclerosis.
Flavio Vincenti, Fernando C Fervenza, Kirk N Campbell, Montserrat Diaz, Loreto Gesualdo, Steven Ledbetter

Kidney Int Rep· September 2017

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Blocking TGF-β Signaling Pathway Preserves Mitochondrial Proteostasis and Reduces Early Activation of PDGFRβ+ Pericytes in Aristolochic Acid Induced Acute Kidney Injury in Wistar Male Rats.
Agnieszka A Pozdzik, Laetitia Giordano, Gang Li, Marie-Hélène Antoine, Nathalie Quellard, Steven R Ledbetter

PLoS One· July 2017

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CaMKII as a pathological mediator of ER stress, oxidative stress, and mitochondrial dysfunction in a murine model of nephronophthisis.
Christina Bracken, Philippe Beauverger, Olivier Duclos, Ryan J Russo, Kelly A Rogers, Steven R Ledbetter

Am J Physiol Renal Physiol· June 2016

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Differences in the timing and magnitude of Pkd1 gene deletion determine the severity of polycystic kidney disease in an orthologous mouse model of ADPKD.
Kelly A Rogers, Sarah E Moreno, Laurie A Smith, Hervé Husson, Nikolay O Bukanov, Steven R Ledbetter

Physiol Rep· June 2016

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Reduction of ciliary length through pharmacologic or genetic inhibition of CDK5 attenuates polycystic kidney disease in a model of nephronophthisis.
Hervé Husson, Sarah Moreno, Laurie A Smith, Mandy M Smith, Ryan J Russo, Steven R Ledbetter

Hum Mol Genet· June 2016

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Role of TGF-β in a mouse model of high turnover renal osteodystrophy.
Shiguang Liu, Wenping Song, Joseph H Boulanger, Wen Tang, Yves Sabbagh, Steven R Ledbetter

J Bone Miner Res· December 2014

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Increased cellular senescence and vascular rarefaction exacerbate the progression of kidney fibrosis in aged mice following transient ischemic injury.
Meghan E Clements, Christopher J Chaber, Steven R Ledbetter, Anna Zuk

PLoS One· March 2014

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Glomerulopathy in the KK.Cg-A(y) /J mouse reflects the pathology of diabetic nephropathy.
Stephen P O'Brien, Mandy Smith, Hong Ling, Lucy Phillips, William Weber, Steven Ledbetter

J Diabetes Res· January 2014

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CDK inhibitors R-roscovitine and S-CR8 effectively block renal and hepatic cystogenesis in an orthologous model of ADPKD.
Nikolay O Bukanov, Sarah E Moreno, Thomas A Natoli, Kelly A Rogers, Laurie A Smith, Steven R Ledbetter

Cell Cycle· November 2012

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Npt2b deletion attenuates hyperphosphatemia associated with CKD.
Susan C Schiavi, Wen Tang, Christina Bracken, Stephen P O'Brien, Wenping Song, Steven Ledbetter

J Am Soc Nephrol· October 2012

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Repression of osteocyte Wnt/β-catenin signaling is an early event in the progression of renal osteodystrophy.
Yves Sabbagh, Fabiana Giorgeti Graciolli, Stephen O'Brien, Wen Tang, Luciene Machado dos Reis, Steven Ledbetter

J Bone Miner Res· August 2012

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Loss of GM3 synthase gene, but not sphingosine kinase 1, is protective against murine nephronophthisis-related polycystic kidney disease.
Thomas A Natoli, Hervé Husson, Kelly A Rogers, Laurie A Smith, Bing Wang, Steven R Ledbetter

Hum Mol Genet· August 2012

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Renoprotective effects of anti-TGF-β antibody and antihypertensive therapies in Dahl S rats.
Sydney R Murphy, Annette J Dahly-Vernon, Kathryn M J Dunn, Chun Cheng Andy Chen, Steven R Ledbetter

Am J Physiol Regul Integr Comp Physiol· July 2012

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A phase 1, single-dose study of fresolimumab, an anti-TGF-β antibody, in treatment-resistant primary focal segmental glomerulosclerosis.
Howard Trachtman, Fernando C Fervenza, Debbie S Gipson, Peter Heering, David R W Jayne, Steven R Ledbetter

Kidney Int· June 2011

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Inhibition of glucosylceramide accumulation results in effective blockade of polycystic kidney disease in mouse models.
Thomas A Natoli, Laurie A Smith, Kelly A Rogers, Bing Wang, Svetlana Komarnitsky, Steven R Ledbetter

Nat Med· July 2010

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Protective effect of 20-HETE analogues in experimental renal ischemia reperfusion injury.
Kevin R Regner, Anna Zuk, Scott K Van Why, Brian D Shames, Robert P Ryan, Steven R Ledbetter

Kidney Int· March 2009

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Effect of combination therapy with enalapril and the TGF-beta antagonist 1D11 in unilateral ureteral obstruction.
Maher El Chaar, Jie Chen, Surya V Seshan, Sharda Jha, Ingride Richardson, Steven R Ledbetter

Am J Physiol Renal Physiol· April 2007

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Long-lasting arrest of murine polycystic kidney disease with CDK inhibitor roscovitine.
Nikolay O Bukanov, Laurie A Smith, Katherine W Klinger, Steven R Ledbetter, Oxana Ibraghimov-Beskrovnaya

Nature· December 2006

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Isoform-specific activation of latent transforming growth factor beta (LTGF-beta) by reactive oxygen species.
Michael F Jobling, Joni D Mott, Monica T Finnegan, Vladimir Jurukovski, Anna C Erickson, Steven Ledbetter

Radiat Res· December 2006

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The temporal effects of anti-TGF-beta1, 2, and 3 monoclonal antibody on wound healing and hypertrophic scar formation.
Leonard Lu, Alexandrina S Saulis, W Robert Liu, Nakshatra K Roy, Jerome D Chao, Steven Ledbetter

J Am Coll Surg· September 2005

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Transforming growth factor-beta, 20-HETE interaction, and glomerular injury in Dahl salt-sensitive rats.
Annette J Dahly-Vernon, Mukut Sharma, Ellen T McCarthy, Virginia J Savin, Steven R Ledbetter

Hypertension· April 2005

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Anti-transforming growth factor antibody at low but not high doses limits cyclosporine-mediated nephrotoxicity without altering rat cardiac allograft survival: potential of therapeutic applications.
Ashwani K Khanna, Matthew S Plummer, Gail Hilton, Galen M Pieper, Steven Ledbetter

Circulation· December 2004

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Transforming growth factor-beta production and myeloid cells are an effector mechanism through which CD1d-restricted T cells block cytotoxic T lymphocyte-mediated tumor immunosurveillance: abrogation prevents tumor recurrence.
Masaki Terabe, So Matsui, Jong-Myun Park, Mizuko Mamura, Nancy Noben-Trauth, Steven Ledbetter

J Exp Med· December 2003

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Therapeutic role of TGF-beta-neutralizing antibody in mouse cyclosporin A nephropathy: morphologic improvement associated with functional preservation.
Hong Ling, Xuemei Li, Sharda Jha, Wei Wang, Lina Karetskaya, Steven Ledbetter

J Am Soc Nephrol· February 2003

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