Publications by authors named "Steven Reiken"

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L-Type Ca1.3 and HCN Channels Mediate Heart Rate Acceleration by Catecholamines.
Eleonora Torre, Mélanie Faure, Isabelle Bidaud, Matthias Baudot, Marvin Gaillardon, Steven Reiken

Circ Res· December 2025

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Structural basis for simvastatin-induced skeletal muscle weakness associated with type 1 ryanodine receptor T4709M mutation.
Gunnar Weninger, Haikel Dridi, Steven Reiken, Qi Yuan, Nan Zhao

J Clin Invest· December 2025

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Atrial fibrillation-induced neurocognitive and vascular dysfunction is averted by mitochondrial oxidative stress reduction.
Pavithran Guttipatti, Ruiping Ji, Najla Saadallah, Uma Mahesh R Avula, Deniz Z Sonmez, Steven R Reiken

JCI Insight· November 2025

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RYR2 Variants in Catecholaminergic Polymorphic Ventricular Tachycardia Patients: Insights From Protein Structure and Clinical Data.
Alexander Chang, Halil Beqaj, Leah Sittenfeld, Marco C Miotto, Haikel Dridi, Steven Reiken

Circ Arrhythm Electrophysiol· September 2025

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Targeting ryanodine receptors with allopurinol and xanthine derivatives for the treatment of cardiac and musculoskeletal weakness disorders.
Marco C Miotto, Estefania Luna-Figueroa, Carl Tchagou, Laith Bahlouli, Steven Reiken

Proc Natl Acad Sci U S A· June 2025

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Probing the Ca1.2 interactome in heart failure identifies a positive modulator of inotropy and lusitropy.
Aaron Rodriques, Guoxia Liu, Alex Katchman, Sergey Zakharov, Elaine Wan, Steven Reiken

bioRxiv· May 2025

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Universal Prime Editing Therapeutic Strategy for RyR1-Related Myopathies: A Protective Mutation Rescues Leaky RyR1 Channel.
Kelly Godbout, Mathieu Dugas, Steven R Reiken, Sina Ramezani, Alexia Falle

Int J Mol Sci· March 2025

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Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders.
Marco C Miotto, Steven Reiken, Anetta Wronska, Qi Yuan, Haikel Dridi

Nat Commun· September 2024

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Structural insights into the regulation of RyR1 by S100A1.
Gunnar Weninger, Marco C Miotto, Carl Tchagou, Steven Reiken, Haikel Dridi

Proc Natl Acad Sci U S A· July 2024

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Location of ryanodine receptor type 2 mutation predicts age of onset of sudden death in catecholaminergic polymorphic ventricular tachycardia - A systematic review and meta-analysis of case-based literature.
Halil Beqaj, Leah Sittenfeld, Alexander Chang, Marco Miotto, Haikel Dridi, Steven Reiken

medRxiv· March 2024

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Aberrant mitochondrial dynamics contributes to diaphragmatic weakness induced by mechanical ventilation.
Haikel Dridi, Marc Yehya, Robert Barsotti, Yang Liu, Steven Reiken

PNAS Nexus· November 2023

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Personalized medicine in the dish to prevent calcium leak associated with short-coupled polymorphic ventricular tachycardia in patient-derived cardiomyocytes.
Yvonne Sleiman, Steven Reiken, Azzouz Charrabi, Fabrice Jaffré, Leah R Sittenfeld

Stem Cell Res Ther· September 2023

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Targeting ryanodine receptor type 2 to mitigate chemotherapy-induced neurocognitive impairments in mice.
Yang Liu, Steven Reiken, Haikel Dridi, Qi Yuan, Khalid S Mohammad

Sci Transl Med· September 2023

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Defective cerebellar ryanodine receptor type 1 and endoplasmic reticulum calcium 'leak' in tremor pathophysiology.
Regina T Martuscello, Meng-Ling Chen, Steven Reiken, Leah R Sittenfeld, David S Ruff

Acta Neuropathol· August 2023

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Heart failure-induced cognitive dysfunction is mediated by intracellular Ca leak through ryanodine receptor type 2.
Haikel Dridi, Yang Liu, Steven Reiken, Xiaoping Liu, Elentina K Argyrousi

Nat Neurosci· August 2023

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Zoledronic acid improves bone quality and muscle function in a high bone turnover state.
Trupti Trivedi, Mohamed Manaa, Sutha John, Steven Reiken, Sreemala Murthy

bioRxiv· June 2023

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A drug and ATP binding site in type 1 ryanodine receptor.
Zephan Melville, Haikel Dridi, Qi Yuan, Steven Reiken, Anetta Wronska

Structure· July 2022

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Structural analyses of human ryanodine receptor type 2 channels reveal the mechanisms for sudden cardiac death and treatment.
Marco C Miotto, Gunnar Weninger, Haikel Dridi, Qi Yuan, Yang Liu, Steven Reiken

Sci Adv· July 2022

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Role of oxidation of excitation-contraction coupling machinery in age-dependent loss of muscle function in .
Haikel Dridi, Frances Forrester, Alisa Umanskaya, Wenjun Xie, Steven Reiken

Elife· May 2022

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IP3 receptor orchestrates maladaptive vascular responses in heart failure.
Haikel Dridi, Gaetano Santulli, Jessica Gambardella, Stanislovas S Jankauskas, Qi Yuan, Steven Reiken

J Clin Invest· February 2022

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Acute RyR1 Ca leak enhances NADH-linked mitochondrial respiratory capacity.
Nadège Zanou, Haikel Dridi, Steven Reiken, Tanes Imamura de Lima, Chris Donnelly

Nat Commun· December 2021

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RyR1-related myopathy mutations in ATP and calcium binding sites impair channel regulation.
Qi Yuan, Haikel Dridi, Oliver B Clarke, Steven Reiken, Zephan Melville

Acta Neuropathol Commun· November 2021

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Attenuating persistent sodium current-induced atrial myopathy and fibrillation by preventing mitochondrial oxidative stress.
Uma Mahesh R Avula, Haikel Dridi, Bi-Xing Chen, Qi Yuan, Alexander N Katchman, Steven R Reiken

JCI Insight· October 2021

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Ryanodine receptor remodeling in cardiomyopathy and muscular dystrophy caused by lamin A/C gene mutation.
Haikel Dridi, Wei Wu, Steven R Reiken, Rachel M Ofer, Yang Liu

Hum Mol Genet· February 2021

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Late Ventilator-Induced Diaphragmatic Dysfunction After Extubation.
Haikel Dridi, Boris Jung, Mohamad Yehya, Aurelien Daurat, Steven Reiken

Crit Care Med· December 2020

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