Publications by authors named "Steven S Plotkin"

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Relationship between efficacy and preferential targeting of soluble Aβ aggregates.
Johanne M Kaplan, Ebrima Gibbs, Juliane A Coutts, Beibei Zhao, Ian R Mackenzie, Steven S Plotkin

Alzheimers Dement (N Y)· December 2025

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Drug Development.
Neil R Cashman, Steven S Plotkin, Scott Napper, Ebrima Gibbs, Beibei Zhao

Alzheimers Dement· December 2025

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Reproductive success of inbred strain MV31 of the ctenophore in a self-sustaining inland laboratory culture system.
Pranav Garg, Cameron Frey, William E Browne, Steven S Plotkin

Heliyon· February 2025

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Amyloidogenic regions in beta-strands II and III modulate the aggregation and toxicity of SOD1 in living cells.
Luke McAlary, Jeremy R Nan, Clay Shyu, Mine Sher, Steven S Plotkin

Open Biol· June 2024

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Tryptophan residues in TDP-43 and SOD1 modulate the cross-seeding and toxicity of SOD1.
Edward Pokrishevsky, Michéle G DuVal, Luke McAlary, Sarah Louadi, Silvia Pozzi, Steven S Plotkin

J Biol Chem· May 2024

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Testing the feasibility of targeting a conserved region on the S2 domain of the SARS-CoV-2 spike protein.
Pranav Garg, Shawn C C Hsueh, Steven S Plotkin

Biophys J· April 2024

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Cyclization Scaffolding for Improved Vaccine Immunogen Stability: Application to Tau Protein in Alzheimer's Disease.
Shawn C C Hsueh, Mark Nijland, Adekunle Aina, Steven S Plotkin

J Chem Inf Model· March 2024

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De Novo Design of a β-Helix Tau Protein Scaffold: An Oligomer-Selective Vaccine Immunogen Candidate for Alzheimer's Disease.
Adekunle Aina, Shawn C C Hsueh, Ebrima Gibbs, Xubiao Peng, Neil R Cashman, Steven S Plotkin

ACS Chem Neurosci· August 2023

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PROTHON: A Local Order Parameter-Based Method for Efficient Comparison of Protein Ensembles.
Adekunle Aina, Shawn C C Hsueh, Steven S Plotkin

J Chem Inf Model· June 2023

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Assessment of protein inclusions in cultured cells using automated image analysis.
Luke McAlary, Victoria K Shephard, Mine Sher, Lauren J Rice, Justin J Yerbury, Steven S Plotkin

STAR Protoc· December 2022

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Ensemble Generation for Linear and Cyclic Peptides Using a Reservoir Replica Exchange Molecular Dynamics Implementation in GROMACS.
Shawn C C Hsueh, Adekunle Aina, Steven S Plotkin

J Phys Chem B· December 2022

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Rational Generation of Monoclonal Antibodies Selective for Pathogenic Forms of Alpha-Synuclein.
Ebrima Gibbs, Beibei Zhao, Andrei Roman, Steven S Plotkin, Xubiao Peng

Biomedicines· September 2022

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Misfolding-Associated Exposure of Natively Buried Residues in Mutant SOD1 Facilitates Binding to TRAF6.
Pranav Garg, Sabrina Semmler, Charlotte Baudouin, Christine Vande Velde, Steven S Plotkin

J Mol Biol· August 2022

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Optimizing Epitope Conformational Ensembles Using α-Synuclein Cyclic Peptide "Glycindel" Scaffolds: A Customized Immunogen Method for Generating Oligomer-Selective Antibodies for Parkinson's Disease.
Shawn C C Hsueh, Adekunle Aina, Andrei Yu Roman, Neil R Cashman, Xubiao Peng, Steven S Plotkin

ACS Chem Neurosci· August 2022

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First Principles Calculation of Protein-Protein Dimer Affinities of ALS-Associated SOD1 Mutants.
Shawn C C Hsueh, Mark Nijland, Xubiao Peng, Benjamin Hilton, Steven S Plotkin

Front Mol Biosci· March 2022

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A method for systematically ranking therapeutic drug candidates using multiple uncertain screening criteria.
Xubiao Peng, Ebrima Gibbs, Judith M Silverman, Neil R Cashman, Steven S Plotkin

Stat Methods Med Res· June 2021

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Passive immunotherapies targeting Aβ and tau in Alzheimer's disease.
Steven S Plotkin, Neil R Cashman

Neurobiol Dis· October 2020

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Purification and Structural Characterization of Aggregation-Prone Human TDP-43 Involved in Neurodegenerative Diseases.
Gareth S A Wright, Tatiana F Watanabe, Kangsa Amporndanai, Steven S Plotkin, Neil R Cashman

iScience· June 2020

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TNF receptor-associated factor 6 interacts with ALS-linked misfolded superoxide dismutase 1 and promotes aggregation.
Sabrina Semmler, Myriam Gagné, Pranav Garg, Sarah R Pickles, Charlotte Baudouin, Steven S Plotkin

J Biol Chem· March 2020

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Therapeutic targeting of the PI4K2A/PKR lysosome network is critical for misfolded protein clearance and survival in cancer cells.
Apar Pataer, Bulent Ozpolat, RuPing Shao, Neil R Cashman, Steven S Plotkin

Oncogene· January 2020

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Corrigendum: Prion-Like Propagation of Protein Misfolding and Aggregation in Amyotrophic Lateral Sclerosis.
Luke McAlary, Steven S Plotkin, Justin J Yerbury, Neil R Cashman

Front Mol Neurosci· January 2020

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Prion-Like Propagation of Protein Misfolding and Aggregation in Amyotrophic Lateral Sclerosis.
Luke McAlary, Steven S Plotkin, Justin J Yerbury, Neil R Cashman

Front Mol Neurosci· November 2019

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Emerging Developments in Targeting Proteotoxicity in Neurodegenerative Diseases.
Luke McAlary, Steven S Plotkin, Neil R Cashman

CNS Drugs· September 2019

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A Rationally Designed Humanized Antibody Selective for Amyloid Beta Oligomers in Alzheimer's Disease.
Ebrima Gibbs, Judith M Silverman, Beibei Zhao, Xubiao Peng, Jing Wang, Steven S Plotkin

Sci Rep· July 2019

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CuATSM Protects Against the In Vitro Cytotoxicity of Wild-Type-Like Copper-Zinc Superoxide Dismutase Mutants but not Mutants That Disrupt Metal Binding.
Natalie E Farrawell, Maddison R Yerbury, Steven S Plotkin, Luke McAlary, Justin J Yerbury

ACS Chem Neurosci· March 2019

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