Publications by authors named "Steven Sheriff"

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Improving the diffraction quality of heat-shock protein 47 crystals.
Kevin Kish, Stephen Cobell, Nicolas Szapiel, Chunhong Yan, John A Newitt, Steven Sheriff

Acta Crystallogr F Struct Biol Commun· November 2024

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Development of BET Inhibitors as Potential Treatments for Cancer: Optimization of Pharmacokinetic Properties.
Matthew D Hill, Haiquan Fang, Derek Norris, George V Delucca, Hong Huang, Steven Sheriff

ACS Med Chem Lett· July 2022

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Discovery of Milvexian, a High-Affinity, Orally Bioavailable Inhibitor of Factor XIa in Clinical Studies for Antithrombotic Therapy.
Andrew K Dilger, Kumar B Pabbisetty, James R Corte, Indawati De Lucca, Tianan Fang, Steven Sheriff

J Med Chem· February 2022

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Development of BET inhibitors as potential treatments for cancer: A new carboline chemotype.
Matthew D Hill, Claude Quesnelle, John Tokarski, Haiquan Fang, Carolynn Fanslau, Steven Sheriff

Bioorg Med Chem Lett· November 2021

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Discovery and Preclinical Pharmacology of an Oral Bromodomain and Extra-Terminal (BET) Inhibitor Using Scaffold-Hopping and Structure-Guided Drug Design.
Ashvinikumar V Gavai, Derek Norris, George Delucca, David Tortolani, John S Tokarski, Steven Sheriff

J Med Chem· October 2021

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Development of BET inhibitors as potential treatments for cancer: A search for structural diversity.
Matthew D Hill, Haiquan Fang, John Tokarski, Carolynn Fanslau, Zuzana Haarhoff, Steven Sheriff

Bioorg Med Chem Lett· July 2021

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Discovery of Orally Active Isofuranones as Potent, Selective Inhibitors of Hematopoetic Progenitor Kinase 1.
Andrew P Degnan, Godwin K Kumi, Christopher W Allard, Erika V Araujo, Walter L Johnson, Steven Sheriff

ACS Med Chem Lett· March 2021

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Using yeast surface display to engineer a soluble and crystallizable construct of hematopoietic progenitor kinase 1 (HPK1).
Wai L Lau, Bradley Pearce, Heather Malakian, Iyoncy Rodrigo, Dianlin Xie, Steven Sheriff

Acta Crystallogr F Struct Biol Commun· January 2021

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Biologic-like In Vivo Efficacy with Small Molecule Inhibitors of TNFα Identified Using Scaffold Hopping and Structure-Based Drug Design Approaches.
Hai-Yun Xiao, Ning Li, James J-W Duan, Bin Jiang, Zhonghui Lu, Steven Sheriff

J Med Chem· December 2020

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Discovery of a High Affinity, Orally Bioavailable Macrocyclic FXIa Inhibitor with Antithrombotic Activity in Preclinical Species.
Wu Yang, Yufeng Wang, Amy Lai, Charles G Clark, James R Corte, Steven Sheriff

J Med Chem· July 2020

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Orally bioavailable amine-linked macrocyclic inhibitors of factor XIa.
Tianan Fang, James R Corte, Paul J Gilligan, Yoon Jeon, Honey Osuna, Steven Sheriff

Bioorg Med Chem Lett· February 2020

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Discovery of BMS-986260, a Potent, Selective, and Orally Bioavailable TGFβR1 Inhibitor as an Immuno-oncology Agent.
Upender Velaparthi, Chetan Padmakar Darne, Jayakumar Warrier, Peiying Liu, Hasibur Rahaman, Steven Sheriff

ACS Med Chem Lett· February 2020

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Potent, Orally Bioavailable, and Efficacious Macrocyclic Inhibitors of Factor XIa. Discovery of Pyridine-Based Macrocycles Possessing Phenylazole Carboxamide P1 Groups.
James R Corte, Donald J P Pinto, Tianan Fang, Honey Osuna, Wu Yang, Steven Sheriff

J Med Chem· January 2020

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Structure based design of macrocyclic factor XIa inhibitors: Discovery of cyclic P1 linker moieties with improved oral bioavailability.
Charles G Clark, Karen A Rossi, James R Corte, Tianan Fang, Joanne M Smallheer, Steven Sheriff

Bioorg Med Chem Lett· October 2019

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Discovery of Clinical Candidate BMS-823778 as an Inhibitor of Human 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD-1).
Jun Li, Lawrence J Kennedy, Steven J Walker, Haixia Wang, James J Li, Steven Sheriff

ACS Med Chem Lett· December 2018

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Structure-Property Basis for Solving Transporter-Mediated Efflux and Pan-Genotypic Inhibition in HCV NS5B Inhibitors.
Kap-Sun Yeung, Brett R Beno, Kathy Mosure, Juliang Zhu, Katherine A Grant-Young, Steven Sheriff

ACS Med Chem Lett· December 2018

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Discovery of 4-Azaindole Inhibitors of TGFβRI as Immuno-oncology Agents.
Yong Zhang, Yufen Zhao, Andrew J Tebben, Steven Sheriff, Max Ruzanov

ACS Med Chem Lett· November 2018

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Pyridazine and pyridazinone derivatives as potent and selective factor XIa inhibitors.
Zilun Hu, Cailan Wang, Wei Han, Karen A Rossi, Jeffrey M Bozarth, Steven Sheriff

Bioorg Med Chem Lett· April 2018

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Heterobicyclic inhibitors of transforming growth factor beta receptor I (TGFβRI).
Lalgudi S Harikrishnan, Jayakumar Warrier, Andrew J Tebben, Gopikishan Tonukunuru, Sudhakara R Madduri, Steven Sheriff

Bioorg Med Chem· March 2018

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Discovery of a Parenteral Small Molecule Coagulation Factor XIa Inhibitor Clinical Candidate (BMS-962212).
Donald J P Pinto, Michael J Orwat, Leon M Smith, Mimi L Quan, Patrick Y S Lam, Steven Sheriff

J Med Chem· December 2017

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Macrocyclic factor XIa inhibitors.
Cailan Wang, James R Corte, Karen A Rossi, Jeffrey M Bozarth, Yiming Wu, Steven Sheriff

Bioorg Med Chem Lett· September 2017

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Macrocyclic inhibitors of Factor XIa: Discovery of alkyl-substituted macrocyclic amide linkers with improved potency.
James R Corte, Wu Yang, Tianan Fang, Yufeng Wang, Honey Osuna, Steven Sheriff

Bioorg Med Chem Lett· August 2017

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Discovery of Clinical Candidate 2-((2S,6S)-2-Phenyl-6-hydroxyadamantan-2-yl)-1-(3'-hydroxyazetidin-1-yl)ethanone [BMS-816336], an Orally Active Novel Selective 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor.
Xiang-Yang Ye, Stephanie Y Chen, Shung Wu, David S Yoon, Haixia Wang, Steven Sheriff

J Med Chem· June 2017

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Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies.
Kap-Sun Yeung, Brett R Beno, Kyle Parcella, John A Bender, Katherine A Grant-Young, Steven Sheriff

J Med Chem· May 2017

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The discovery of a pan-genotypic, primer grip inhibitor of HCV NS5B polymerase.
Kyle J Eastman, Kyle Parcella, Kap-Sun Yeung, Katharine A Grant-Young, Juliang Zhu, Steven Sheriff

Medchemcomm· April 2017

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