Publications by authors named "Stuart Haynes"

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Structural and functional characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase 2 function via a novel non-competitive mechanism of action.
Mark Austin, Daniel Burschowsky, Denice T Y Chan, Lesley Jenkinson, Stuart Haynes

MAbs· July 2021

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Extensive sequence and structural evolution of Arginase 2 inhibitory antibodies enabled by an unbiased approach to affinity maturation.
Denice T Y Chan, Lesley Jenkinson, Stuart W Haynes, Mark Austin, Agata Diamandakis

Proc Natl Acad Sci U S A· July 2020

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Stereochemistry and Mechanism of Undecylprodigiosin Oxidative Carbocyclization to Streptorubin B by the Rieske Oxygenase RedG.
David M Withall, Stuart W Haynes, Gregory L Challis

J Am Chem Soc· June 2015

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Short pathways to complexity generation: fungal peptidyl alkaloid multicyclic scaffolds from anthranilate building blocks.
Christopher T Walsh, Stuart W Haynes, Brian D Ames, Xue Gao, Yi Tang

ACS Chem Biol· July 2013

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Complexity generation in fungal peptidyl alkaloid biosynthesis: a two-enzyme pathway to the hexacyclic MDR export pump inhibitor ardeemin.
Stuart W Haynes, Xue Gao, Yi Tang, Christopher T Walsh

ACS Chem Biol· April 2013

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Cyclization of fungal nonribosomal peptides by a terminal condensation-like domain.
Xue Gao, Stuart W Haynes, Brian D Ames, Peng Wang, Linda P Vien

Nat Chem Biol· October 2012

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Assembly of asperlicin peptidyl alkaloids from anthranilate and tryptophan: a two-enzyme pathway generates heptacyclic scaffold complexity in asperlicin E.
Stuart W Haynes, Xue Gao, Yi Tang, Christopher T Walsh

J Am Chem Soc· October 2012

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Aminobenzoates as building blocks for natural product assembly lines.
Christopher T Walsh, Stuart W Haynes, Brian D Ames

Nat Prod Rep· January 2012

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Complexity generation in fungal peptidyl alkaloid biosynthesis: oxidation of fumiquinazoline A to the heptacyclic hemiaminal fumiquinazoline C by the flavoenzyme Af12070 from Aspergillus fumigatus.
Brian D Ames, Stuart W Haynes, Xue Gao, Bradley S Evans, Neil L Kelleher

Biochemistry· October 2011

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Antimalarial activity of natural and synthetic prodiginines.
Kancharla Papireddy, Martin Smilkstein, Jane Xu Kelly, Shweta, Shaimaa M Salem, Stuart W Haynes

J Med Chem· August 2011

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Unraveling terminal C-domain-mediated condensation in fungal biosynthesis of imidazoindolone metabolites.
Stuart W Haynes, Brian D Ames, Xue Gao, Yi Tang, Christopher T Walsh

Biochemistry· June 2011

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Regio- and stereodivergent antibiotic oxidative carbocyclizations catalysed by Rieske oxygenase-like enzymes.
Paulina K Sydor, Sarah M Barry, Olanipekun M Odulate, Francisco Barona-Gomez, Stuart W Haynes

Nat Chem· May 2011

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Stereochemical elucidation of streptorubin B.
Stuart W Haynes, Paulina K Sydor, Christophe Corre, Lijiang Song, Gregory L Challis

J Am Chem Soc· February 2011

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A butenolide intermediate in methylenomycin furan biosynthesis is implied by incorporation of stereospecifically 13C-labelled glycerols.
Christophe Corre, Stuart W Haynes, Nicolas Malet, Lijiang Song, Gregory L Challis

Chem Commun (Camb)· June 2010

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Role and substrate specificity of the Streptomyces coelicolor RedH enzyme in undecylprodiginine biosynthesis.
Stuart W Haynes, Paulina K Sydor, Anna E Stanley, Lijiang Song, Gregory L Challis

Chem Commun (Camb)· April 2008

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Elucidation of the Streptomyces coelicolor pathway to 2-undecylpyrrole, a key intermediate in undecylprodiginine and streptorubin B biosynthesis.
SangJoon Mo, Paulina K Sydor, Christophe Corre, Mamoun M Alhamadsheh, Anna E Stanley, Stuart W Haynes

Chem Biol· February 2008

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Non-linear enzymatic logic in natural product modular mega-synthases and -synthetases.
Stuart W Haynes, Gregory L Challis

Curr Opin Drug Discov Devel· March 2007

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