Publications by authors named "Stuart Le Grice"

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Autophagy Deregulation in HIV-1-Infected Cells Increases Extracellular Vesicle Release and Contributes to TLR3 Activation.
Catherine DeMarino, Maria Cowen, Anastasia Williams, Pooja Khatkar, Fardokht A Abulwerdi, Stuart F J Le Grice

Viruses· April 2024

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HIV-1 Transcription Inhibition Using Small RNA-Binding Molecules.
Pooja Khatkar, Gifty Mensah, Shangbo Ning, Maria Cowen, Yuriy Kim, Stuart F J Le Grice

Pharmaceuticals (Basel)· December 2023

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Dihydroxyphenyl- and Heteroaromatic-Based Thienopyrimidinones to Tackle HIV-1 LEDGF/p75-Dependent IN Activity.
Graziella Tocco, Serena Canton, Antonio Laus, Pierluigi Caboni, Stuart F J Le Grice

Molecules· September 2023

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Discovery of Small Molecules Targeting the Frameshifting Element RNA in SARS-CoV-2 Viral Genome.
Mo Yang, Feyisola P Olatunji, Curran Rhodes, Sumirtha Balaratnam, Kara Dunne-Dombrink, Stuart F J Le Grice

ACS Med Chem Lett· June 2023

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Structural insights of the conserved "priming loop" of hepatitis B virus pre-genomic RNA.
Regan M LeBlanc, Wojciech K Kasprzak, Andrew P Longhini, Lukasz T Olenginski, Fardokht Abulwerdi, Stuart F J Le Grice

J Biomol Struct Dyn· December 2022

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Dataset of high-throughput ligand screening against the RNA Packaging Signals regulating Hepatitis B Virus nucleocapsid formation.
Fardokht Abulwerdi, Farzad Fatehi, Iain W Manfield, Stuart F J Le Grice, John S Schneekloth

Data Brief· June 2022

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Dysregulation of Hepatitis B Virus Nucleocapsid Assembly in vitro by RNA-binding Small Ligands.
Nikesh Patel, Fardokht Abulwerdi, Farzad Fatehi, Iain W Manfield, Stuart Le Grice

J Mol Biol· May 2022

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Dynamic bulge nucleotides in the KSHV PAN ENE triple helix provide a unique binding platform for small molecule ligands.
Monalisa Swain, Abeer A Ageeli, Wojciech K Kasprzak, Mi Li, Jennifer T Miller, Stuart F J Le Grice

Nucleic Acids Res· December 2021

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Characterizing the Latent HIV-1 Reservoir in Patients with Viremia Suppressed on cART: Progress, Challenges, and Opportunities.
Jason W Rausch, Stuart F J Le Grice

Curr HIV Res· June 2021

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Adeno-Associated Viral Vector Mediated Expression of Broadly- Neutralizing Antibodies Against HIV-Hitting a Fast-Moving Target.
Chringma Sherpa, Stuart F J Le Grice

Curr HIV Res· June 2021

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HIV Genetic Diversity - Superpower of a Formidable Virus.
Chringma Sherpa, Jason W Rausch, Stuart F J Le Grice

Curr HIV Res· June 2021

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Characterizing and circumventing sequence restrictions for synthesis of circular RNA in vitro.
Jason W Rausch, William F Heinz, Matthew J Payea, Chringma Sherpa, Myriam Gorospe, Stuart F J Le Grice

Nucleic Acids Res· April 2021

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Scaffold hopping and optimisation of 3',4'-dihydroxyphenyl- containing thienopyrimidinones: synthesis of quinazolinone derivatives as novel allosteric inhibitors of HIV-1 reverse transcriptase-associated ribonuclease H.
Graziella Tocco, Francesca Esposito, Pierluigi Caboni, Antonio Laus, John A Beutler, Stuart F J Le Grice

J Enzyme Inhib Med Chem· December 2020

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3,7-Dihydroxytropolones Inhibit Initiation of Hepatitis B Virus Minus-Strand DNA Synthesis.
Ellen Bak, Jennifer T Miller, Andrea Noronha, John Tavis, Emilio Gallicchio, Stuart F J Le Grice

Molecules· September 2020

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Molecular recognition of HIV-1 RNAs with branched peptides.
Ashley N Peralta, Yumin Dai, Chringma Sherpa, Stuart F J Le Grice, Webster L Santos

Methods Enzymol· May 2020

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Evolution of the HIV-1 Rev Response Element during Natural Infection Reveals Nucleotide Changes That Correlate with Altered Structure and Increased Activity over Time.
Chringma Sherpa, Patrick E H Jackson, Laurie R Gray, Kathryn Anastos, Stuart F J Le Grice

J Virol· June 2019

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Interplay of primary sequence, position and secondary RNA structure determines alternative splicing of LMNA in a pre-mature aging syndrome.
Asaf Shilo, Frances Anne Tosto, Jason W Rausch, Stuart F J Le Grice, Tom Misteli

Nucleic Acids Res· June 2019

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Molecular recognition of a branched peptide with HIV-1 Rev Response Element (RRE) RNA.
Yumin Dai, Ashley N Peralta, Jessica E Wynn, Chringma Sherpa, Hao Li, Stuart F J Le Grice

Bioorg Med Chem· April 2019

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Meeting report: Fourth Summer School on Innovative Approaches for Identification of Antiviral Agents (IAAASS).
Stuart Le Grice, Elias Maccioni, Angela Corona, Cristina Parolin, Enzo Tramontano

Antiviral Res· February 2019

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Selective Small-Molecule Targeting of a Triple Helix Encoded by the Long Noncoding RNA, MALAT1.
Fardokht A Abulwerdi, Wenbo Xu, Abeer A Ageeli, Michael J Yonkunas, Gayatri Arun, Stuart F J Le Grice

ACS Chem Biol· February 2019

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Structural characterization of maternally expressed gene 3 RNA reveals conserved motifs and potential sites of interaction with polycomb repressive complex 2.
Chringma Sherpa, Jason W Rausch, Stuart Fj Le Grice

Nucleic Acids Res· November 2018

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Discovery of a Branched Peptide That Recognizes the Rev Response Element (RRE) RNA and Blocks HIV-1 Replication.
Yumin Dai, Jessica E Wynn, Ashley N Peralta, Chringma Sherpa, Bhargavi Jayaraman, Stuart F Le Grice

J Med Chem· November 2018

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APOL1 risk allele RNA contributes to renal toxicity by activating protein kinase R.
Koji Okamoto, Jason W Rausch, Hidefumi Wakashin, Yulong Fu, Joon-Yong Chung, Stuart F J Le Grice

Commun Biol· November 2018

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Polymorphisms in KSHV-encoded microRNA sequences affect levels of mature viral microRNA in Kaposi Sarcoma lesions.
Vickie A Marshall, Nazzarena Labo, Joanna Sztuba-Solinska, Elena M Cornejo Castro, Karen Aleman, Stuart F J Le Grice

Oncotarget· November 2018

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Sensitivity of the C-Terminal Nuclease Domain of Kaposi's Sarcoma-Associated Herpesvirus ORF29 to Two Classes of Active-Site Ligands.
Jennifer T Miller, Haiyan Zhao, Takashi Masaoka, Brittany Varnado, Elena M Cornejo Castro, Stuart F J Le Grice

Antimicrob Agents Chemother· October 2018

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