Publications by authors named "Stuart Naylor"

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Development of a Deep Learning Tool to Support the Assessment of Thyroid Follicular Cell Hypertrophy in the Rat.
Stuart W Naylor, Elizabeth F McInnes, James Alibhai, Scott Burgess, James Baily

Toxicol Pathol· April 2025

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Gene therapy in children with AIPL1-associated severe retinal dystrophy: an open-label, first-in-human interventional study.
Michel Michaelides, Yannik Laich, Sui Chien Wong, Ngozi Oluonye, Serena Zaman, Stuart Naylor

Lancet· February 2025

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Phase 1/2 AAV5-hRKp.RPGR (Botaretigene Sparoparvovec) Gene Therapy: Safety and Efficacy in RPGR-Associated X-Linked Retinitis Pigmentosa.
Michel Michaelides, Cagri G Besirli, Yesa Yang, Thales A C DE Guimaraes, Sui Chien Wong, Stuart Naylor

Am J Ophthalmol· November 2024

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AAV-RPGR Gene Therapy Rescues Opsin Mislocalisation in a Human Retinal Organoid Model of -Associated X-Linked Retinitis Pigmentosa.
Paul E Sladen, Arifa Naeem, Toyin Adefila-Ideozu, Tijmen Vermeule, Sophie L Busson, Stuart Naylor

Int J Mol Sci· February 2024

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First-in-Human Gene Therapy Trial of AAV8-hCARp.hCNGB3 in Adults and Children With CNGB3-associated Achromatopsia.
Michel Michaelides, Nashila Hirji, Sui Chien Wong, Cagri G Besirli, Serena Zaman, Stuart Naylor

Am J Ophthalmol· September 2023

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Letter to the editor: 'Emerging gene therapy products for -associated X-linked retinitis pigmentosa'.
Anastasios Georgiadis, Alexander J Smith, Michel Michaelides, Stuart Naylor, Alexandria Forbes

Expert Opin Emerg Drugs· December 2022

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The Influence of Geographical Origin, Age, Sex, and Animal Husbandry on the Spontaneous Histopathology of Laboratory Cynomolgus Macaques (): A Contemporary Global and Multisite Review of Historical Control Data.
Ronnie Chamanza, Stuart W Naylor, Michela Gregori, Molly Boyle, Marcia E Pereira Bacares

Toxicol Pathol· July 2022

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Proof of Concept: The Use of Whole-Slide Images (WSI) for Peer Review of Tissues on Routine Regulatory Toxicology Studies.
Alys E Bradley, Maurice G Cary, Kaori Isobe, Stuart Naylor, Stephen Drew

Toxicol Pathol· June 2021

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Multisite Analysis of Lesions in the Respiratory Tract of the Rat and Nonhuman Primate (Cynomolgus Monkey) Exposed to Air, Vehicle, and Inhaled Small Molecule Compounds.
Michela Gregori, Stuart W Naylor, Mark C Freke, Ronnie Chamanza, Alessandro Piaia

Toxicol Pathol· February 2021

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BSTP Review of 12 Case Studies Discussing the Challenges, Pathology, Immunogenicity, and Mechanisms of Inhaled Biologics.
A Peter Hall, Jeffrey S Tepper, Molly H Boyle, Maurice G Cary, Thierry G Flandre, Stuart Naylor

Toxicol Pathol· February 2021

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Normal Anatomy, Histology, and Spontaneous Pathology of the Kidney, and Selected Renal Biomarker Reference Ranges in the Cynomolgus Monkey.
Ronnie Chamanza, Stuart W Naylor, Vinicius Carreira, Chidozie Amuzie, Jing Ying Ma

Toxicol Pathol· July 2019

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Histopathological Findings in Cynomolgus Macaques ( Macaca fascicularis) Consistent with Secondary Immunological Reaction to Biotherapeutics with an Emphasis on the CNS and Eye.
Stuart W Naylor, Melissa Czajkowski, Warren Harvey, Matt Smith, Alys E Bradley

Toxicol Pathol· February 2019

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Lentiviral Vector Gene Transfer of Endostatin/Angiostatin for Macular Degeneration (GEM) Study.
Peter A Campochiaro, Andreas K Lauer, Elliott H Sohn, Tahreem A Mir, Stuart Naylor

Hum Gene Ther· January 2017

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Adrenal Gland Background Findings in CD-1 (Crl:CD-1(ICR)BR) Mice from 104-week Carcinogenicity Studies.
Claudio Petterino, Stuart Naylor, Sydney Mukaratirwa, Alys Bradley

Toxicol Pathol· August 2015

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Incidences and Range of Spontaneous Lesions in the Eye of Crl:CD-1(ICR)BR Mice Used in Toxicity Studies.
Sydney Mukaratirwa, Claudio Petterino, Stuart W Naylor, Alys Bradley

Toxicol Pathol· June 2015

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Long-term safety and tolerability of ProSavin, a lentiviral vector-based gene therapy for Parkinson's disease: a dose escalation, open-label, phase 1/2 trial.
Stéphane Palfi, Jean Marc Gurruchaga, G Scott Ralph, Helene Lepetit, Sonia Lavisse, Stuart Naylor

Lancet· March 2014

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Transduction of photoreceptors with equine infectious anemia virus lentiviral vectors: safety and biodistribution of StarGen for Stargardt disease.
Katie Binley, Peter Widdowson, Julie Loader, Michelle Kelleher, Sharifah Iqball, Stuart Naylor

Invest Ophthalmol Vis Sci· June 2013

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Analysis of pre-treatment markers predictive of treatment benefit for the therapeutic cancer vaccine MVA-5T4 (TroVax).
Richard Harrop, Peter Treasure, Jackie de Belin, Michelle Kelleher, Gemma Bolton, Stuart Naylor

Cancer Immunol Immunother· December 2012

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Safety and biodistribution of an equine infectious anemia virus-based gene therapy, RetinoStat(®), for age-related macular degeneration.
Katie Binley, Peter S Widdowson, Michelle Kelleher, Jackie de Belin, Julie Loader, Stuart Naylor

Hum Gene Ther· September 2012

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Spontaneous cerebellar primitive neuroectodermal tumor in a juvenile cynomolgus monkey (Macaca fascicularis).
Sydney Mukaratirwa, Petrina Rogerson, Ana L Blanco, Stuart W Naylor, Alys Bradley

Toxicol Pathol· August 2012

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MVA-5T4-induced immune responses are an early marker of efficacy in renal cancer patients.
Richard Harrop, William H Shingler, Mike McDonald, Peter Treasure, Robert J Amato, Stuart Naylor

Cancer Immunol Immunother· June 2011

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Genetically modified macrophages expressing hypoxia regulated cytochrome P450 and P450 reductase for the treatment of cancer.
On Kan, Debbie Day, Sharifah Iqball, Frances Burke, Matthew J Grimshaw, Stuart Naylor

Int J Mol Med· February 2011

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Vaccination of metastatic renal cancer patients with MVA-5T4: a randomized, double-blind, placebo-controlled phase III study.
Robert J Amato, Robert E Hawkins, Howard L Kaufman, John A Thompson, Piotr Tomczak, Stuart Naylor

Clin Cancer Res· November 2010

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Incidences and range of spontaneous findings in control cynomolgus monkeys (Macaca fascicularis) used in toxicity studies.
Ronnie Chamanza, Heike A Marxfeld, Ana I Blanco, Stuart W Naylor, Alys E Bradley

Toxicol Pathol· June 2010

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Vaccination of renal cell cancer patients with modified vaccinia Ankara delivering the tumor antigen 5T4 (TroVax) alone or administered in combination with interferon-alpha (IFN-alpha): a phase 2 trial.
Robert J Amato, William Shingler, Madusha Goonewardena, Jackie de Belin, Stuart Naylor

J Immunother· September 2009

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