Publications by authors named "Sucha Singh"

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Glutamine synthetase loss in β-catenin-mutant hepatocellular carcinoma promotes tumor burden through macrophage metabolic reprogramming.
Evan R Delgado, Panari Patel, Junyan Tao, Yekaterina Krutsenko, Silvia Liu, Sucha Singh, Aatur Singhi

Hepatology· October 2025

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Precision targeting of β-catenin induces tumor reprogramming and immunity in hepatocellular cancers.
Brandon M Lehrich, Evan R Delgado, Tyler M Yasaka, Silvia Liu, Catherine Cao, Sucha Singh, Anya Singh-Varma

Nat Commun· May 2025

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Development of mutated β-catenin gene signature to identify mutations from whole and spatial transcriptomic data in patients with HCC.
Brandon M Lehrich, Junyan Tao, Silvia Liu, Theo Z Hirsch, Tyler M Yasaka, Sucha Singh, Aatur D Singhi

JHEP Rep· December 2024

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Precision targeting of β-catenin induces tumor reprogramming and immunity in hepatocellular cancers.
Brandon M Lehrich, Evan R Delgado, Tyler M Yasaka, Silvia Liu, Catherine Cao, Sucha Singh, Anya Singh-Varma

Res Sq· December 2024

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Huntingtin loss in hepatocytes is associated with altered metabolism, adhesion, and liver zonation.
Robert M Bragg, Sydney R Coffey, Jeffrey P Cantle, Shikai Hu, Sucha Singh

Life Sci Alliance· November 2023

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Loss of TAZ after YAP deletion severely impairs foregut development and worsens cholestatic hepatocellular injury.
Adelya Gabdulkhakova, Yekaterina Krutsenko, Junjie Zhu, Silvia Liu, Minakshi Poddar, Sucha Singh

Hepatol Commun· September 2023

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Huntingtin loss in hepatocytes is associated with altered metabolism, adhesion, and liver zonation.
Robert M Bragg, Sydney R Coffey, Jeffrey P Cantle, Shikai Hu, Sucha Singh

bioRxiv· June 2023

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Hepatocyte β-catenin loss is compensated by Insulin-mTORC1 activation to promote liver regeneration.
Shikai Hu, Catherine Cao, Minakshi Poddar, Evan Delgado, Sucha Singh, Anya Singh-Varma

Hepatology· May 2023

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Inhibition of Heat Shock Factor 1 Signaling Decreases Hepatoblastoma Growth via Induction of Apoptosis.
Edward H Hurley, Junyan Tao, Silvia Liu, Yekaterina Krutsenko, Sucha Singh

Am J Pathol· February 2023

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Single-cell spatial transcriptomics reveals a dynamic control of metabolic zonation and liver regeneration by endothelial cell Wnt2 and Wnt9b.
Shikai Hu, Silvia Liu, Yu Bian, Minakshi Poddar, Sucha Singh

Cell Rep Med· October 2022

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NOTCH-YAP1/TEAD-DNMT1 Axis Drives Hepatocyte Reprogramming Into Intrahepatic Cholangiocarcinoma.
Shikai Hu, Laura Molina, Junyan Tao, Silvia Liu, Mohammed Hassan, Sucha Singh, Aatur Singhi

Gastroenterology· August 2022

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Myeloid FoxO1 depletion attenuates hepatic inflammation and prevents nonalcoholic steatohepatitis.
Sojin Lee, Taofeek O Usman, Jun Yamauchi, Goma Chhetri, Xingchun Wang, Sucha Singh, Aatur D Singhi

J Clin Invest· July 2022

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WNT7B Regulates Cholangiocyte Proliferation and Function During Murine Cholestasis.
Karis Kosar, Pamela Cornuet, Sucha Singh, Elizabeth Lee, Silvia Liu

Hepatol Commun· December 2021

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β-Catenin-NF-κB-CFTR interactions in cholangiocytes regulate inflammation and fibrosis during ductular reaction.
Shikai Hu, Jacquelyn O Russell, Silvia Liu, Catherine Cao, Jackson McGaughey, Sucha Singh, Aatur D Singhi

Elife· October 2021

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Nuclear factor erythroid 2-related factor 2 and β-Catenin Coactivation in Hepatocellular Cancer: Biological and Therapeutic Implications.
Junyan Tao, Yekaterina Krutsenko, Akshata Moghe, Sucha Singh, Minakshi Poddar, Aatur D Singhi

Hepatology· August 2021

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Compensatory hepatic adaptation accompanies permanent absence of intrahepatic biliary network due to YAP1 loss in liver progenitors.
Laura M Molina, Junjie Zhu, Qin Li, Tirthadipa Pradhan-Sundd, Yekaterina Krutsenko, Sucha Singh, Aatur Singhi

Cell Rep· July 2021

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Dual β-Catenin and γ-Catenin Loss in Hepatocytes Impacts Their Polarity through Altered Transforming Growth Factor-β and Hepatocyte Nuclear Factor 4α Signaling.
Tirthadipa Pradhan-Sundd, Silvia Liu, Sucha Singh, Minakshi Poddar, Sungjin Ko

Am J Pathol· May 2021

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Impaired Bile Secretion Promotes Hepatobiliary Injury in Sickle Cell Disease.
Ravi Vats, Silvia Liu, Junjie Zhu, Dhanunjay Mukhi, Egemen Tutuncuoglu, Sucha Singh

Hepatology· December 2020

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Hepatic Stellate Cell-Specific Platelet-Derived Growth Factor Receptor-α Loss Reduces Fibrosis and Promotes Repair after Hepatocellular Injury.
Alexander Kikuchi, Sucha Singh, Minakshi Poddar, Toshimasa Nakao, Heidi Marie Schmidt

Am J Pathol· October 2020

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Wnt/β-Catenin Signaling Plays a Protective Role in the Mdr2 Knockout Murine Model of Cholestatic Liver Disease.
Tirthadipa Pradhan-Sundd, Karis Kosar, Harvinder Saggi, Rong Zhang, Ravi Vats, Sucha Singh

Hepatology· May 2020

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The Thyromimetic Sobetirome (GC-1) Alters Bile Acid Metabolism in a Mouse Model of Hepatic Cholestasis.
Karis Kosar, Pamela Cornuet, Sucha Singh, Silvia Liu, Kari Nejak-Bowen

Am J Pathol· May 2020

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Depletion of hepatic forkhead box O1 does not affect cholelithiasis in male and female mice.
Xiaoyun Feng, Cuiling Zhu, Sojin Lee, Jingyang Gao, Ping Zhu, Sucha Singh

J Biol Chem· May 2020

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Activation of WNT/Beta-Catenin Signaling and Regulation of the Farnesoid X Receptor/Beta-Catenin Complex After Murine Bile Duct Ligation.
Rong Zhang, Toshimasa Nakao, Jing Luo, Yuhua Xue, Pamela Cornuet, Sucha Singh

Hepatol Commun· December 2019

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Correction: mTOR inhibition affects Yap1-β-catenin-induced hepatoblastoma growth and development.
Laura Molina, Hong Yang, Adeola O Adebayo Michael, Michael Oertel, Aaron Bell, Sucha Singh

Oncotarget· September 2019

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mTOR inhibition affects Yap1-β-catenin-induced hepatoblastoma growth and development.
Laura Molina, Hong Yang, Adeola O Adebayo Michael, Michael Oertel, Aaron Bell, Sucha Singh

Oncotarget· February 2019

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