Publications by authors named "Sudhir Raghavan"

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Targeting the Leloir Pathway with Galactose-Based Antimetabolites in Glioblastoma.
Martyn A Sharpe, Omkar B Ijare, Sudhir Raghavan, Alexandra M Baskin, Brianna N Baskin

Cancers (Basel)· October 2024

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Prodrugs of a 1-Hydroxy-2-oxopiperidin-3-yl Phosphonate Enolase Inhibitor for the Treatment of -Deleted Cancers.
Victoria C Yan, Cong-Dat Pham, Elliot S Ballato, Kristine L Yang, Kenisha Arthur, Sudhir Raghavan

J Med Chem· October 2022

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MP-Pt(IV): A MAOB-Sensitive Mitochondrial-Specific Prodrug for Treating Glioblastoma.
Sudhir Raghavan, David S Baskin, Martyn A Sharpe

Mol Cancer Ther· December 2020

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A "Clickable" Probe for Active MGMT in Glioblastoma Demonstrates Two Discrete Populations of MGMT.
Sudhir Raghavan, David S Baskin, Martyn A Sharpe

Cancers (Basel)· February 2020

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The 3 Enantiomer Drives Enolase Inhibitory Activity in SF2312 and Its Analogues.
Federica Pisaneschi, Yu-Hsi Lin, Paul G Leonard, Nikunj Satani, Victoria C Yan, Sudhir Raghavan

Molecules· July 2019

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Development and validation of chemical features-based proton-coupled folate transporter/activity and reduced folate carrier/activity models (pharmacophores).
Khushbu Shah, Sudhir Raghavan, Zhanjun Hou, Larry H Matherly, Aleem Gangjee

J Mol Graph Model· May 2018

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PAM-OBG: A monoamine oxidase B specific prodrug that inhibits MGMT and generates DNA interstrand crosslinks, potentiating temozolomide and chemoradiation therapy in intracranial glioblastoma.
Martyn A Sharpe, Sudhir Raghavan, David S Baskin

Oncotarget· May 2018

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ENOblock Does Not Inhibit the Activity of the Glycolytic Enzyme Enolase.
Nikunj Satani, Yu-Hsi Lin, Naima Hammoudi, Sudhir Raghavan, Dimitra K Georgiou

PLoS One· July 2017

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Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis.
Lalit K Golani, Adrianne Wallace-Povirk, Siobhan M Deis, Jennifer Wong, Jiyuan Ke, Sudhir Raghavan

J Med Chem· September 2016

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Correction to Structure-Activity Profiles of Novel 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Antifolates with Modified Amino Acids for Cellular Uptake by Folate Receptors α and β and the Proton-Coupled Folate Transporter.
Lalit K Golani, Christina George, Sai Zhao, Sudhir Raghavan, Steven Orr

J Med Chem· April 2016

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6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human Tumors.
Lei Wang, Adrianne Wallace, Sudhir Raghavan, Siobhan M Deis, Mike R Wilson

J Med Chem· September 2015

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The design, synthesis and biological evaluation of conformationally restricted 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multi-targeted receptor tyrosine kinase and microtubule inhibitors as potential antitumor agents.
Xin Zhang, Sudhir Raghavan, Michael Ihnat, Ernest Hamel, Cynthia Zammiello

Bioorg Med Chem· May 2015

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Novel 5-substituted pyrrolo[2,3-d]pyrimidines as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase and as potential antitumor agents.
Yiqiang Wang, Shermaine Mitchell-Ryan, Sudhir Raghavan, Christina George, Steven Orr

J Med Chem· February 2015

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Structure-activity profiles of novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolates with modified amino acids for cellular uptake by folate receptors α and β and the proton-coupled folate transporter.
Lalit K Golani, Christina George, Sai Zhao, Sudhir Raghavan, Steven Orr

J Med Chem· October 2014

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The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents.
Xin Zhang, Sudhir Raghavan, Michael Ihnat, Jessica E Thorpe, Bryan C Disch

Bioorg Med Chem· July 2014

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Discovery of 5-substituted pyrrolo[2,3-d]pyrimidine antifolates as dual-acting inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis: implications of inhibiting 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase to ampk activation and antitumor activity.
Shermaine Mitchell-Ryan, Yiqiang Wang, Sudhir Raghavan, Manasa Punaha Ravindra, Eric Hales

J Med Chem· December 2013

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Tumor-targeting with novel non-benzoyl 6-substituted straight chain pyrrolo[2,3-d]pyrimidine antifolates via cellular uptake by folate receptor α and inhibition of de novo purine nucleotide biosynthesis.
Yiqiang Wang, Christina Cherian, Steven Orr, Shermaine Mitchell-Ryan, Zhanjun Hou, Sudhir Raghavan

J Med Chem· November 2013

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Structure-activity relationship and in vitro and in vivo evaluation of the potent cytotoxic anti-microtubule agent N-(4-methoxyphenyl)-N,2,6-trimethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-aminium chloride and its analogues as antitumor agents.
Aleem Gangjee, Ying Zhao, Sudhir Raghavan, Cristina C Rohena, Susan L Mooberry

J Med Chem· September 2013

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Design, synthesis, and molecular modeling of novel pyrido[2,3-d]pyrimidine analogues as antifolates; application of Buchwald-Hartwig aminations of heterocycles.
Aleem Gangjee, Ojas A Namjoshi, Sudhir Raghavan, Sherry F Queener, Roy L Kisliuk

J Med Chem· June 2013

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Synthesis and biological activity of 5-chloro-N⁴-substituted phenyl-9H-pyrimido[4,5-b]indole-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic agents.
Aleem Gangjee, Nilesh Zaware, Sudhir Raghavan, Bryan C Disch, Jessica E Thorpe

Bioorg Med Chem· April 2013

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Synthesis of N(4)-(substituted phenyl)-N(4)-alkyl/desalkyl-9H-pyrimido[4,5-b]indole-2,4-diamines and identification of new microtubule disrupting compounds that are effective against multidrug resistant cells.
Aleem Gangjee, Nilesh Zaware, Ravi Kumar Vyas Devambatla, Sudhir Raghavan, Cara D Westbrook

Bioorg Med Chem· February 2013

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N⁴-(3-Bromophenyl)-7-(substituted benzyl) pyrrolo[2,3-d]pyrimidines as potent multiple receptor tyrosine kinase inhibitors: design, synthesis, and in vivo evaluation.
Aleem Gangjee, Nilesh Zaware, Sudhir Raghavan, Jie Yang, Jessica E Thorpe

Bioorg Med Chem· April 2012

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Synthesis and discovery of water-soluble microtubule targeting agents that bind to the colchicine site on tubulin and circumvent Pgp mediated resistance.
Aleem Gangjee, Ying Zhao, Lu Lin, Sudhir Raghavan, Elizabeth G Roberts

J Med Chem· November 2010

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Design, synthesis and evaluation of 2-amino-4-m-bromoanilino-6-arylmethyl-7H-pyrrolo[2,3-d]pyrimidines as tyrosine kinase inhibitors and antiangiogenic agents.
Aleem Gangjee, Ying Zhao, Sudhir Raghavan, Michael A Ihnat, Bryan C Disch

Bioorg Med Chem· July 2010

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Single agents with designed combination chemotherapy potential: synthesis and evaluation of substituted pyrimido[4,5-b]indoles as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents.
Aleem Gangjee, Nilesh Zaware, Sudhir Raghavan, Michael Ihnat, Satyendra Shenoy

J Med Chem· February 2010

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