Publications by authors named "Sungchae Hong"

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Design and evaluation of IKK-activated GSK3β inhibitory peptide as an inflammation-responsive anti-colitic therapeutic.
Sungchae Hong, Sanghyun Ju, Jin-Wook Yoo, Nam-Chul Ha, Yunjin Jung

Biomater Sci· September 2021

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Lipophilic modification enhances anti-colitic properties of rosmarinic acid by potentiating its HIF-prolyl hydroxylases inhibitory activity.
Seongkeun Jeong, Huijeong Park, Sungchae Hong, Soohwan Yum, Wooseong Kim

Eur J Pharmacol· January 2015

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Colon-targeted celecoxib ameliorates TNBS-induced rat colitis: a potential pharmacologic mechanism and therapeutic advantages.
Yonghyun Lee, Wooseong Kim, Sungchae Hong, Huijeong Park, Soohwan Yum

Eur J Pharmacol· March 2014

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N-(2-Mercaptopropionyl)-glycine, a diffusible antioxidant, activates HIF-1 by inhibiting HIF prolyl hydroxylase-2: implication in amelioration of rat colitis by the antioxidant.
Soohwan Yum, Huijeong Park, Sungchae Hong, Seongkeun Jeong, Wooseong Kim

Biochem Biophys Res Commun· January 2014

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Caffeic acid phenethyl ester activation of Nrf2 pathway is enhanced under oxidative state: structural analysis and potential as a pathologically targeted therapeutic agent in treatment of colonic inflammation.
Hyunjeong Kim, Wooseong Kim, Soohwan Yum, Sungchae Hong, Jeong-Eun Oh

Free Radic Biol Med· December 2013

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Piceatannol, a hydroxystilbene natural product, stabilizes HIF-1α protein by inhibiting HIF prolyl hydroxylase.
Soohwan Yum, Hea-Jeong Doh, Sungchae Hong, Seongkeun Jeong, Dae-Duk Kim

Eur J Pharmacol· January 2013

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Colon-targeted cell-permeable NFκB inhibitory peptide is orally active against experimental colitis.
Sungchae Hong, Soohwan Yum, Hyun-Jung Yoo, Sookjin Kang, Jeong-Hyun Yoon

Mol Pharm· May 2012

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Structure-activity relationship of salicylic acid derivatives on inhibition of TNF-α dependent NFκB activity: Implication on anti-inflammatory effect of N-(5-chlorosalicyloyl)phenethylamine against experimental colitis.
Jihye Kim, Sookjin Kang, Sungchae Hong, Soowhan Yum, Young Mi Kim

Eur J Med Chem· February 2012

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Susceptibility of glucocorticoids to colonic metabolism and pharmacologic intervention in the metabolism: implication for therapeutic activity of colon-specific glucocorticoid 21-sulfate sodium at the target site.
Hyesik Kong, Yonghyun Lee, Hyunjeong Kim, Sungchae Hong, Dae-Duk Kim

J Pharm Pharmacol· January 2012

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Hyperoxia attenuates the inhibitory effect of nitric oxide donors on HIF prolyl-4-hydroxylase-2: Implication on discriminative effect of nitric oxide on HIF prolyl-4-hydroxylase-2 and collagen prolyl-4-hydroxylase.
Soohwan Yum, Jeongyoun Choi, Sungchae Hong, Myung Hee Park, Jaewon Lee

Biochem Pharmacol· September 2011

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Structural effects of N-aromatic acyl-amino acid conjugates on their deconjugation in the cecal contents of rats: implication in design of a colon-specific prodrug with controlled conversion rate at the target site.
Hyesik Kong, Hyunjeong Kim, Heejeong Do, Yonghyun Lee, Sungchae Hong

Biopharm Drug Dispos· September 2011

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von Hippel-Lindau β-domain-luciferase fusion protein as a bioluminescent hydroxyproline sensor for a hypoxia-inducible factor prolyl hydroxylase assay.
Sungchae Hong, Soohwan Yum, Nam-Chul Ha, Yunjin Jung

Anal Biochem· December 2010

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Caffeic acid phenethyl ester is a potent inhibitor of HIF prolyl hydroxylase: structural analysis and pharmacological implication.
Daekyu Choi, Jeongoh Han, Youna Lee, Jungyun Choi, Songyi Han, Sungchae Hong

J Nutr Biochem· September 2010

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Caffeic acid phenethyl ester-mediated Nrf2 activation and IkappaB kinase inhibition are involved in NFkappaB inhibitory effect: structural analysis for NFkappaB inhibition.
Youna Lee, Dong-Ha Shin, Ji-Hye Kim, Sungchae Hong, Daekyu Choi

Eur J Pharmacol· September 2010

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Synthesis and evaluation of N-nicotinoyl-2-{2-(2-methyl-5-nitroimidazol-1-yl)ethyloxy}-D,L-glycine as a colon-specific prodrug of metronidazole.
Duksoo Kim, Sungchae Hong, Sunhwa Jung, Yunjin Jung, Young Mi Kim

J Pharm Sci· November 2009

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An anti-inflammatory mechanism of taurine conjugated 5-aminosalicylic acid against experimental colitis: taurine chloramine potentiates inhibitory effect of 5-aminosalicylic acid on IL-1beta-mediated NFkappaB activation.
Kanghyun Joo, Youna Lee, Deakyu Choi, Jeongoh Han, Sungchae Hong

Eur J Pharmacol· September 2009

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Sulfate-conjugated methylprednisolone as a colon-targeted methylprednisolone prodrug with improved therapeutic properties against rat colitis.
Hyesik Kong, Younghyun Lee, Sungchae Hong, Jeongoh Han, Biom Choi

J Drug Target· July 2009

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Manganese (II) induces chemical hypoxia by inhibiting HIF-prolyl hydroxylase: implication in manganese-induced pulmonary inflammation.
Jeongoh Han, Jong-Suk Lee, Daekyu Choi, Youna Lee, Sungchae Hong

Toxicol Appl Pharmacol· March 2009

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Dexamethasone 21-sulfate improves the therapeutic properties of dexamethasone against experimental rat colitis by specifically delivering the steroid to the large intestine.
Inho Kim, Hyesik Kong, Younghyun Lee, Sungchae Hong, Jungoh Han

Pharm Res· February 2009

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