Publications by authors named "Sunil A David"

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Virus-like particle vaccines targeting a key epitope in circumsporozoite protein provide sterilizing immunity against malaria.
Yogesh Nepal, Alexandra Francian, Yevel Flores-Garcia, Bryce T Roberts, Sunil A David

NPJ Vaccines· July 2025

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Virus-like particle vaccines targeting a key epitope in circumsporozoite protein provide sterilizing immunity against malaria.
Yogesh Nepal, Alexandra Francian, Yevel Flores-Garcia, Bryce T Roberts, Sunil A David

bioRxiv· May 2025

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Human M1 macrophages express unique innate immune response genes after mycobacterial infection to defend against tuberculosis.
Arshad Khan, Kangling Zhang, Vipul K Singh, Abhishek Mishra, Priyanka Kachroo, David H Canaday, Sunil A David

Commun Biol· May 2022

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Systemically Administered TLR7/8 Agonist and Antigen-Conjugated Nanogels Govern Immune Responses against Tumors.
Judith Stickdorn, Lara Stein, Danielle Arnold-Schild, Jennifer Hahlbrock, Carolina Medina-Montano, Sunil A David

ACS Nano· March 2022

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High-Titer Neutralizing Antibodies against the SARS-CoV-2 Delta Variant Induced by Alhydroxyquim-II-Adjuvanted Trimeric Spike Antigens.
Claudio Counoupas, Paco Pino, Alberto O Stella, Caroline Ashley, Hannah Lukeman, Sunil A David

Microbiol Spectr· February 2022

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A universal bacteriophage T4 nanoparticle platform to design multiplex SARS-CoV-2 vaccine candidates by CRISPR engineering.
Jingen Zhu, Neeti Ananthaswamy, Swati Jain, Himanshu Batra, Wei-Chun Tang, Sunil A David

Sci Adv· September 2021

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Squaric Ester-Based, pH-Degradable Nanogels: Modular Nanocarriers for Safe, Systemic Administration of Toll-like Receptor 7/8 Agonistic Immune Modulators.
Anne Huppertsberg, Leonard Kaps, Zifu Zhong, Sascha Schmitt, Judith Stickdorn, Sunil A David

J Am Chem Soc· July 2021

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Corrigendum: Sterilizing Immunity against SARS-CoV-2 Infection in Mice by a Single-Shot and Lipid Amphiphile Imidazoquinoline TLR7/8 Agonist-Adjuvanted Recombinant Spike Protein Vaccine.
Sonia Jangra, Jana De Vrieze, Angela Choi, Raveen Rathnasinghe, Gabriel Laghlali, Sunil A David

Angew Chem Int Ed Engl· July 2021

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Sterilizing Immunity against SARS-CoV-2 Infection in Mice by a Single-Shot and Lipid Amphiphile Imidazoquinoline TLR7/8 Agonist-Adjuvanted Recombinant Spike Protein Vaccine*.
Sonia Jangra, Jana De Vrieze, Angela Choi, Raveen Rathnasinghe, Gabriel Laghlali, Sunil A David

Angew Chem Int Ed Engl· April 2021

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Lipid-Polyglutamate Nanoparticle Vaccine Platform.
Dorien Van Lysebetten, Alessio Malfanti, Kim Deswarte, Kaloian Koynov, Bianka Golba, Sunil A David

ACS Appl Mater Interfaces· February 2021

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A Universal Bacteriophage T4 Nanoparticle Platform to Design Multiplex SARS-CoV-2 Vaccine Candidates by CRISPR Engineering.
Jingen Zhu, Neeti Ananthaswamy, Swati Jain, Himanshu Batra, Wei-Chun Tang, Sunil A David

bioRxiv· January 2021

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Imidazoquinoline-Conjugated Degradable Coacervate Conjugate for Local Cancer Immunotherapy.
Hui Li, Simon Van Herck, Yongjun Liu, Yanyun Hao, Xiaochu Ding, Sunil A David

ACS Biomater Sci Eng· September 2020

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Potent and Prolonged Innate Immune Activation by Enzyme-Responsive Imidazoquinoline TLR7/8 Agonist Prodrug Vesicles.
Bi Wang, Simon Van Herck, Yong Chen, Xiangyang Bai, Zifu Zhong, Sunil A David

J Am Chem Soc· July 2020

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Control over Imidazoquinoline Immune Stimulation by pH-Degradable Poly(norbornene) Nanogels.
Johannes Kockelmann, Judith Stickdorn, Sabah Kasmi, Jana De Vrieze, Michaela Pieszka, David Yuen W Ng, Sunil A David

Biomacromolecules· June 2020

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Potent Lymphatic Translocation and Spatial Control Over Innate Immune Activation by Polymer-Lipid Amphiphile Conjugates of Small-Molecule TLR7/8 Agonists.
Jana De Vrieze, Benoit Louage, Kim Deswarte, Zifu Zhong, Ruben De Coen, Sunil A David

Angew Chem Int Ed Engl· October 2019

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Identification of Human Toll-like Receptor 2-Agonistic Activity in Dihydropyridine-Quinolone Carboxamides.
Ziwei Hu, Janardhan Banothu, Mallesh Beesu, Collin J Gustafson, Michael J H Brush, Sunil A David

ACS Med Chem Lett· January 2019

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Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands.
Zhikuan Zhang, Umeharu Ohto, Takuma Shibata, Masato Taoka, Yoshio Yamauchi, Sunil A David

Cell Rep· December 2018

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Nanoparticle-Conjugate TLR7/8 Agonist Localized Immunotherapy Provokes Safe Antitumoral Responses.
Lutz Nuhn, Stefaan De Koker, Sandra Van Lint, Zifu Zhong, João Portela Catani, Sunil A David

Adv Mater· November 2018

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Lymph-Node-Targeted Immune Activation by Engineered Block Copolymer Amphiphiles-TLR7/8 Agonist Conjugates.
Simon Van Herck, Kim Deswarte, Lutz Nuhn, Zifu Zhong, Joao Paulo Portela Catani, Sunil A David

J Am Chem Soc· October 2018

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Potent anti-viral vaccine adjuvant based on pH-degradable nanogels with covalently linked small molecule imidazoquinoline TLR7/8 agonist.
Lutz Nuhn, Lien Van Hoecke, Kim Deswarte, Bert Schepens, Yupeng Li, Sunil A David

Biomaterials· September 2018

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Hyaluronic Acid Conjugates of TLR7/8 Agonists for Targeted Delivery to Secondary Lymphoid Tissue.
Euna Yoo, Alex C D Salyer, Michael J H Brush, Yupeng Li, Kathryn L Trautman, Sunil A David

Bioconjug Chem· August 2018

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Transcriptomal signatures of vaccine adjuvants and accessory immunostimulation of sentinel cells by toll-like receptor 2/6 agonists.
Alex C D Salyer, Sunil A David

Hum Vaccin Immunother· July 2018

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Transiently Thermoresponsive Acetal Polymers for Safe and Effective Administration of Amphotericin B as a Vaccine Adjuvant.
Simon Van Herck, Lien Van Hoecke, Benoit Louage, Lien Lybaert, Ruben De Coen, Sunil A David

Bioconjug Chem· March 2018

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Syntheses of Human TLR8-Specific Small-Molecule Agonists.
Mallesh Beesu, Hari Prasad Kokatla, Sunil A David

Methods Mol Biol· January 2018

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Identification of High-Potency Human TLR8 and Dual TLR7/TLR8 Agonists in Pyrimidine-2,4-diamines.
Mallesh Beesu, Alex C D Salyer, Michael J H Brush, Kathryn L Trautman, Justin K Hill, Sunil A David

J Med Chem· March 2017

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