Publications by authors named "Susan Crennell"

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Structurally Informed Mutagenesis of a Stereochemically Promiscuous Aldolase Produces Mutants That Catalyze the Diastereoselective Syntheses of All Four Stereoisomers of 3-Deoxy-hexulosonic Acid.
Sylvain F Royer, Xuan Gao, Robin R Groleau, Marc W van der Kamp, Steven D Bull, Susan J Crennell

ACS Catal· September 2022

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Staphylococcal Complement Evasion Protein Sbi Stabilises C3d Dimers by Inducing an N-Terminal Helix Swap.
Rhys W Dunphy, Ayla A Wahid, Catherine R Back, Rebecca L Martin, Andrew G Watts, Susan J Crennell

Front Immunol· June 2022

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Insights Into the Structure-Function Relationships of Dimeric C3d Fragments.
Ayla A Wahid, Rhys W Dunphy, Alex Macpherson, Beth G Gibson, Liudmila Kulik, Susan J Crennell

Front Immunol· December 2021

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The allosteric modulation of complement C5 by knob domain peptides.
Alex Macpherson, Maisem Laabei, Zainab Ahdash, Melissa A Graewert, James R Birtley, Susan Crennell

Elife· February 2021

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The synthesis and kinetic evaluation of aryl α-aminophosphonates as novel inhibitors of T. cruzi trans-sialidase.
Zexin Chen, Patricia Marcé, Ricardo Resende, Pedro M Alzari, A Carlos Frasch, Susan J Crennell

Eur J Med Chem· October 2018

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Insights into the Substrate Specificity of Archaeal Entner-Doudoroff Aldolases: The Structures of Picrophilus torridus 2-Keto-3-deoxygluconate Aldolase and Sulfolobus solfataricus 2-Keto-3-deoxy-6-phosphogluconate Aldolase in Complex with 2-Keto-3-deoxy-6-phosphogluconate.
Viatcheslav Zaitsev, Ulrike Johnsen, Matthias Reher, Marius Ortjohann, Garry L Taylor, Susan J Crennell

Biochemistry· July 2018

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Distinctive phosphoinositide- and Ca-binding properties of normal and cognitive performance-linked variant forms of KIBRA C2 domain.
Mareike G Posner, Abhishek Upadhyay, Rieko Ishima, Antreas C Kalli, Gemma Harris, Susan J Crennell

J Biol Chem· June 2018

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Crystal structure of an inferred ancestral bacterial pyruvate decarboxylase.
Lisa Buddrus, Emma S V Andrews, David J Leak, Michael J Danson, Vickery L Arcus, Susan J Crennell

Acta Crystallogr F Struct Biol Commun· March 2018

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Structural insights of RmXyn10A - A prebiotic-producing GH10 xylanase with a non-conserved aglycone binding region.
Anna Aronsson, Fatma Güler, Maxim V Petoukhov, Susan J Crennell, Dmitri I Svergun

Biochim Biophys Acta Proteins Proteom· February 2018

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Structure of an acetylating aldehyde dehydrogenase from the thermophilic ethanologen Geobacillus thermoglucosidasius.
Jonathan Extance, Michael J Danson, Susan J Crennell

Protein Sci· November 2016

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Crystal structure of pyruvate decarboxylase from Zymobacter palmae.
Lisa Buddrus, Emma S V Andrews, David J Leak, Michael J Danson, Vickery L Arcus, Susan J Crennell

Acta Crystallogr F Struct Biol Commun· September 2016

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Why are the 2-oxoacid dehydrogenase complexes so large? Generation of an active trimeric complex.
Nia L Marrott, Jacqueline J T Marshall, Dmitri I Svergun, Susan J Crennell, David W Hough

Biochem J· November 2014

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Structures of mesophilic and extremophilic citrate synthases reveal rigidity and flexibility for function.
Stephen A Wells, Susan J Crennell, Michael J Danson

Proteins· October 2014

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A novel β-xylosidase structure from Geobacillus thermoglucosidasius: the first crystal structure of a glycoside hydrolase family GH52 enzyme reveals unpredicted similarity to other glycoside hydrolase folds.
Giannina Espina, Kirstin Eley, Guillaume Pompidor, Thomas R Schneider, Susan J Crennell

Acta Crystallogr D Biol Crystallogr· May 2014

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Structure of a bifunctional alcohol dehydrogenase involved in bioethanol generation in Geobacillus thermoglucosidasius.
Jonathan Extance, Susan J Crennell, Kirstin Eley, Roger Cripps, David W Hough

Acta Crystallogr D Biol Crystallogr· October 2013

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Post-translational modification in the archaea: structural characterization of multi-enzyme complex lipoylation.
Mareike G Posner, Abhishek Upadhyay, Susan J Crennell, Andrew J A Watson, Steve Dorus

Biochem J· January 2013

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The catalytic core of an archaeal 2-oxoacid dehydrogenase multienzyme complex is a 42-mer protein assembly.
Nia L Marrott, Jacqueline J T Marshall, Dmitri I Svergun, Susan J Crennell, David W Hough

FEBS J· March 2012

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Contribution of inter-subunit interactions to the thermostability of Pyrococcus furiosus citrate synthase.
Vicky Moore, Ami Kanu, Olwyn Byron, Gordon Campbell, Michael J Danson, Susan J Crennell

Extremophiles· May 2011

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A structural basis for Staphylococcal complement subversion: X-ray structure of the complement-binding domain of Staphylococcus aureus protein Sbi in complex with ligand C3d.
Elizabeth A Clark, Susan Crennell, Abhishek Upadhyay, Alexey V Zozulya, Julia D Mackay

Mol Immunol· January 2011

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Structurally informed site-directed mutagenesis of a stereochemically promiscuous aldolase to afford stereochemically complementary biocatalysts.
Sylvain F Royer, Luke Haslett, Susan J Crennell, David W Hough, Michael J Danson

J Am Chem Soc· August 2010

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Germline humanization of a non-human primate antibody that neutralizes the anthrax toxin, by in vitro and in silico engineering.
Thibaut Pelat, Hugues Bedouelle, Anthony R Rees, Susan J Crennell, Marie-Paule Lefranc

J Mol Biol· December 2008

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Identification of amino acids essential for catalytic activity of pneumococcal neuraminidase A.
Hasan Yesilkaya, Shital Soma-Haddrick, Susan J Crennell, Peter W Andrew

Res Microbiol· November 2006

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Dimerisation and an increase in active site aromatic groups as adaptations to high temperatures: X-ray solution scattering and substrate-bound crystal structures of Rhodothermus marinus endoglucanase Cel12A.
Susan J Crennell, Danielle Cook, Abby Minns, Dmitri Svergun, Rasmus L Andersen

J Mol Biol· February 2006

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Citrate synthase from Thermus aquaticus: a thermostable bacterial enzyme with a five-membered inter-subunit ionic network.
Eva Nordberg Karlsson, Susan J Crennell, Catherine Higgins, Salina Nawaz, Louisa Yeoh

Extremophiles· February 2003

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Role of the hemagglutinin-neuraminidase protein in the mechanism of paramyxovirus-cell membrane fusion.
Toru Takimoto, Garry L Taylor, Helen C Connaris, Susan J Crennell, Allen Portner

J Virol· December 2002

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