Publications by authors named "Susan P Perrine"

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An oral Hemokine, α-methylhydrocinnamate, enhances myeloid and neutrophil recovery following irradiation in vivo.
Douglas V Faller, Serguei A Castaneda, Daohong Zhou, Merriline Vedamony, Peter E Newburger, Susan P Perrine

Blood Cells Mol Dis· March 2017

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Novel Inducers of Fetal Globin Identified through High Throughput Screening (HTS) Are Active In Vivo in Anemic Baboons and Transgenic Mice.
Michael S Boosalis, Jose I Sangerman, Gary L White, Roman F Wolf, Ling Shen, Susan P Perrine

PLoS One· June 2016

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Therapeutic fetal-globin inducers reduce transcriptional repression in hemoglobinopathy erythroid progenitors through distinct mechanisms.
Yan Dai, Jose Sangerman, Hong Yuan Luo, Suthat Fucharoen, David H K Chui, Susan P Perrine

Blood Cells Mol Dis· January 2016

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Targeted fetal hemoglobin induction for treatment of beta hemoglobinopathies.
Susan P Perrine, Betty S Pace, Douglas V Faller

Hematol Oncol Clin North Am· April 2014

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A phase 2 trial of HQK-1001 in HbE-β thalassemia demonstrates HbF induction and reduced anemia.
Poramin Patthamalai, Suthat Fuchareon, Nattawara Chaneiam, Richard G Ghalie, David H K Chui, Susan P Perrine

Blood· March 2014

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A phase 2 study of HQK-1001, an oral fetal haemoglobin inducer, in β-thalassaemia intermedia.
Adlette Inati, Mario Kahale, Susan P Perrine, David H K Chui, Ali T Taher

Br J Haematol· February 2014

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A dose-escalation phase IIa study of 2,2-dimethylbutyrate (HQK-1001), an oral fetal globin inducer, in sickle cell disease.
Abdullah Kutlar, Marvin E Reid, Adlette Inati, Ali T Taher, Miguel R Abboud, Susan P Perrine

Am J Hematol· November 2013

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A randomized phase I/II trial of HQK-1001, an oral fetal globin gene inducer, in β-thalassaemia intermedia and HbE/β-thalassaemia.
Suthat Fucharoen, Adlette Inati, Noppadol Siritanaratku, Swee L Thein, William C Wargin, Susan P Perrine

Br J Haematol· May 2013

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A phase 1/2 trial of HQK-1001, an oral fetal globin inducer, in sickle cell disease.
Abdullah Kutlar, Kenneth Ataga, Marvin Reid, Elliott P Vichinsky, Lynne Neumayr, Susan P Perrine

Am J Hematol· November 2012

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Advances in Virus-Directed Therapeutics against Epstein-Barr Virus-Associated Malignancies.
Sajal K Ghosh, Susan P Perrine, Douglas V Faller

Adv Virol· August 2012

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Butyrate histone deacetylase inhibitors.
Kosta Steliou, Michael S Boosalis, Susan P Perrine, José Sangerman, Douglas V Faller

Biores Open Access· August 2012

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Histone deacetylase inhibitors are potent inducers of gene expression in latent EBV and sensitize lymphoma cells to nucleoside antiviral agents.
Sajal K Ghosh, Susan P Perrine, Robert M Williams, Douglas V Faller

Blood· January 2012

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Histone deacetylase inhibitors reverse CpG methylation by regulating DNMT1 through ERK signaling.
Sibaji Sarkar, Ana L Abujamra, Jenny E Loew, Lora W Forman, Susan P Perrine

Anticancer Res· September 2011

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Evaluation of safety and pharmacokinetics of sodium 2,2 dimethylbutyrate, a novel short chain fatty acid derivative, in a phase 1, double-blind, placebo-controlled, single-dose, and repeat-dose studies in healthy volunteers.
Susan P Perrine, William A Wargin, Michael S Boosalis, Wayne J Wallis, Sally Case

J Clin Pharmacol· August 2011

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Novel therapeutic candidates, identified by molecular modeling, induce γ-globin gene expression in vivo.
Michael S Boosalis, Serguei A Castaneda, Marie Trudel, Rodwell Mabaera, Gary L White, Susan P Perrine

Blood Cells Mol Dis· August 2011

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Switching globin, raising red cells.
Susan P Perrine

Blood· July 2011

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Short-term toxicity study of ST-20 (NSC-741804) by oral gavage in Sprague-Dawley rats.
Pramod S Terse, Jerry D Johnson, Michael A Hawk, Glenn D Ritchie, Michael J Ryan, Susan P Perrine

Toxicol Pathol· June 2011

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A randomized phase II trial of Arginine Butyrate with standard local therapy in refractory sickle cell leg ulcers.
Lillian McMahon, Hannah Tamary, Melissa Askin, Patricia Adams-Graves, Robert T Eberhardt, Susan P Perrine

Br J Haematol· December 2010

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Fetal globin gene inducers: novel agents and new potential.
Susan P Perrine, Serguei A Castaneda, David H K Chui, Douglas V Faller, Ronald J Berenson

Ann N Y Acad Sci· August 2010

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Effects of divalproex sodium on hemoglobin level.
Ali T Taher, Khaled M Musallam, Wassim Nasreddine, Susan P Perrine, Taghrid I El-Hajj

Blood Cells Mol Dis· September 2009

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Erythroid Kruppel-like factor (EKLF) is recruited to the gamma-globin gene promoter as a co-activator and is required for gamma-globin gene induction by short-chain fatty acid derivatives.
Susan P Perrine, Rishikesh Mankidy, Michael S Boosalis, James J Bieker, Douglas V Faller

Eur J Haematol· June 2009

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Fetal globin stimulant therapies in the beta-hemoglobinopathies: principles and current potential.
Susan P Perrine

Pediatr Ann· May 2008

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Liquid chromatography-mass spectrometric assay for quantitation of the short-chain fatty acid, 2,2-dimethylbutyrate (NSC 741804), in rat plasma.
Robert A Parise, Jan H Beumer, Cyrous O Kangani, Julianne L Holleran, Julie L Eiseman, Susan P Perrine

J Chromatogr B Analyt Technol Biomed Life Sci· February 2008

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Short, discontinuous exposure to butyrate effectively sensitizes latently EBV-infected lymphoma cells to nucleoside analogue antiviral agents.
Sajal K Ghosh, Lora W Forman, Idowu Akinsheye, Susan P Perrine, Douglas V Faller

Blood Cells Mol Dis· October 2007

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A phase 1/2 trial of arginine butyrate and ganciclovir in patients with Epstein-Barr virus-associated lymphoid malignancies.
Susan P Perrine, Olivier Hermine, Trudy Small, Felipe Suarez, Richard O'Reilly

Blood· March 2007

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