Publications by authors named "Susan T Edwards"

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Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor.
Penglie Zhang, Wenrong Huang, Lingyan Wang, Liang Bao, Zhaozhong J Jia, Susan T Edwards

Bioorg Med Chem Lett· April 2009

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1-(2-Naphthyl)-1H-pyrazole-5-carboxylamides as potent factor Xa inhibitors. Part 2: A survey of P4 motifs.
Zhaozhong J Jia, Yanhong Wu, Wenrong Huang, Penglie Zhang, Lane A Clizbe, Susan T Edwards

Bioorg Med Chem Lett· March 2004

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1-(2-Naphthyl)-1H-pyrazole-5-carboxylamides as potent factor Xa inhibitors. Part 3: Design, synthesis and SAR of orally bioavailable benzamidine-P4 inhibitors.
Zhaozhong J Jia, Yanhong Wu, Wenrong Huang, Penglie Zhang, Yonghong Song, Susan T Edwards

Bioorg Med Chem Lett· March 2004

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Risk of early surgery for Crohn's disease: implications for early treatment strategies.
Bruce E Sands, Joanne E Arsenault, Michael J Rosen, Mazen Alsahli, Laurence Bailen, Susan T Edwards

Am J Gastroenterol· December 2003

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Inhibition of purified factor Xa amidolytic activity may not be predictive of inhibition of in vivo thrombosis: implications for identification of therapeutically active inhibitors.
Uma Sinha, Pei Hua Lin, Susan T Edwards, Paul W Wong, Bingyan Zhu

Arterioscler Thromb Vasc Biol· June 2003

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Differences between human and rabbit coagulation factor X-implications for in vivo models of thrombosis.
Susan T Edwards, Andreas Betz, Harold L James, Erika Thompson, Shirlee J Yonkovich

Thromb Res· April 2002

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