Publications by authors named "Syeed Hussain"

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Optimization of a Novel Binding Motif to (E)-3-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic Acid (AZD9496), a Potent and Orally Bioavailable Selective Estrogen Receptor Downregulator and Antagonist.
Chris De Savi, Robert H Bradbury, Alfred A Rabow, Richard A Norman, Camila de Almeida, Syeed Hussain

J Med Chem· October 2015

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Discovery of novel Jak2-Stat pathway inhibitors with extended residence time on target.
Huiping Guan, Michelle L Lamb, Bo Peng, Shan Huang, Nancy Degrace, Syeed Hussain

Bioorg Med Chem Lett· May 2013

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Identification of interactions involved in the generation of nucleophilic reactivity and of catalytic competence in the catalytic site Cys/His ion pair of papain.
Syeed Hussain, Akavish Khan, Sheraz Gul, Marina Resmini, Chandra S Verma

Biochemistry· December 2011

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Structural insights into the catalytic mechanism of Trypanosoma cruzi GPXI (glutathione peroxidase-like enzyme I).
Shreenal Patel, Syeed Hussain, Richard Harris, Sunita Sardiwal, John M Kelly

Biochem J· January 2010

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Structural insights into substrate specificity and the anti beta-elimination mechanism of pectate lyase.
Arefeh Seyedarabi, Teng Teng To, Salyha Ali, Syeed Hussain, Markus Fries

Biochemistry· January 2010

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Generation of nucleophilic character in the Cys25/His159 ion pair of papain involves Trp177 but not Asp158.
Sheraz Gul, Syeed Hussain, Mark P Thomas, Marina Resmini, Chandra S Verma

Biochemistry· February 2008

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Structure of internalin C from Listeria monocytogenes.
Amy Ooi, Syeed Hussain, Arefeh Seyedarabi, Richard W Pickersgill

Acta Crystallogr D Biol Crystallogr· November 2006

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Evidence for 'lock and key' character in an anti-phosphonate hydrolytic antibody catalytic site augmented by non-reaction centre recognition: variation in substrate selectivity between an anti-phosphonate antibody, an anti-phosphate antibody and two hydrolytic enzymes.
Sanjiv Sonkaria, Guillaume Boucher, José Flórez-Olvarez, Bilal Said, Syeed Hussain

Biochem J· July 2004

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Isomerization of the uncomplexed actinidin molecule: kinetic accessibility of additional steps in enzyme catalysis provided by solvent perturbation.
James D Reid, Syeed Hussain, Tamara S F Bailey, Sanjiv Sonkaria, Suneal K Sreedharan

Biochem J· March 2004

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Improvement in hydrolytic antibody activity by change in haptenic structure from phosphate to phosphonate with retention of a common leaving-group determinant: evidence for the 'flexibility' hypothesis.
Sheraz Gul, Sanjiv Sonkaria, Surapong Pinitglang, José Florez-Alvarez, Syeed Hussain

Biochem J· December 2003

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Variation in the pH-dependent pre-steady-state and steady-state kinetic characteristics of cysteine-proteinase mechanism: evidence for electrostatic modulation of catalytic-site function by the neighbouring carboxylate anion.
Syeed Hussain, Surapong Pinitglang, Tamara S F Bailey, James D Reid, Michael A Noble

Biochem J· June 2003

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